DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and kz

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	1054	Identity:	287/1054 - (27%)
Similarity:	433/1054 - (41%)	Gaps:	303/1054 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 GNGMEGDEHE-----SRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADI 458
            ||.:..||..     |.||.|:|...:...:|      :|.:.:..
  Fly    36 GNQVGYDEANALVLPSEKRATKIKVDKVQHVK------ILSKKQRK------------------- 75

  Fly   459 EIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQS----------------ALSKER 507
            .::.:.::.....|..:.|.||:.|:|   |:..|.|...:..                |..|||
  Fly    76 HLQAIVDKKKKKEGRAQLLGDLAAVQI---PEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKER 137

  Fly   508 REQKMLQR--------------------EQEIEAMPTSLNKNWIDPLPEDESRSLA--------- 543
            :.|.:.::                    |:|.|......|.|.|....:||..|.:
  Fly   138 QAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPA 202

  Fly   544 -----ANMRGMAAAPPEV---PEWKK-------------------HVIGGKKSSFGKKTDLTLVE 581
                 |....::.|||::   |..||                   |          :.|::.  .
  Fly   203 QSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVH----------RTTEVQ--N 255

  Fly   582 QRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMS 646
            .|..|||......:::.:.:|.|:||.||||||||||:.|:|.|.|:.....||.|:||||||::
  Fly   256 ARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIA 320

  Fly   647 VAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHER 711
            ::||||.|.... ..||.|.||||...:|.|.||:||||:||:|...:..|..||||:|||||||
  Fly   321 MSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHER 384

  Fly   712 TIHTDVLFGLLKTAVQKRPE----LKLIVTSATLDAVKFSQ--YFFK--APIFTIPGRTFPVEVL 768
            :::||:|.|||...|..|.:    ||||:.||||....|::  ..||  .|:..:..|.|||.:.
  Fly   385 SVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIH 449

  Fly   769 YTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEE--------------------------- 806
            :.|....||:..:....::||.:.|.|.||:|:|||:|
  Fly   450 FQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGK 514

  Fly   807 ---------IDTACEILYERMKSLGPDVPELI--------------------------------- 829
                     ||.|...: |..|.|..|:..:|
  Fly   515 VSEEEKEETIDDAASTV-EDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEA 578

  Fly   830 ----------------------------------------ILPVYSALPSEMQTRIFDPAPAGSR 854
                                                    :||:||.|.||.|.|||.|.|.|.|
  Fly   579 DMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCR 643

  Fly   855 KVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGK 919
            ..|::||:|||||||..|.||||.|..|.::|:..||:.:.|||..|:|:|.||||||||...|.
  Fly   644 LCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGH 708

  Fly   920 TYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHS 984
            .||||:...|.|.......|:||:..:...:||::.|||:.::||.|...|....|..|..:|..
  Fly   709 CYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIV 773

  Fly   985 LSAL--------DDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNV--- 1038
            |.||        |....:||||..::.||:.|...|||.:|.........:.:|:.||||.|
  Fly   774 LGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIE 838

  Fly  1039 ---------------FYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNA------W 1082
                           |:|.:...|.:..     .|..||.:.||....:   .:::.:      :
  Fly   839 TGVQRDEDVAPGANRFHRKRQSWAASGN-----YQLLGDPMVLLRAVGA---AEYAGSQGRLPEF 895

  Fly  1083 CYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVR---------IQKAICSGFFRNAAK 1138
            |..|.::.:.:...:.:|.||...::.:..||.......::         :::.:.:|.....|:
  Fly   896 CAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVAR 960

  Fly  1139 KDP-------------QEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQ-----TTKEYMRE 1185
            |.|             :..|......:..::|.||.|..:.||||||.|..:     :||.::|.
  Fly   961 KVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRG 1025

  Fly  1186 VTTIDPKWLVEFAP 1199
            :|.|:|:||:.:.|
  Fly  1026 ITAIEPEWLLLYVP 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	245/803 (31%)
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	246/825 (30%)
		DEXDc	279..418	CDD:238005	74/139 (53%)
		P-loop_NTPase	369..>500	CDD:304359	50/130 (38%)
		HELICc	619..704	CDD:197757	48/84 (57%)
		HA2	774..859	CDD:214852	23/84 (27%)
		OB_NTP_bind	915..1039	CDD:285018	28/123 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850