Protein Alignment pea and Ythdc2

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_001414131.1
• Gene: Ythdc2 / 307446
• RGDID: 1563192
• Length: 1434
• Species: Rattus norvegicus
• Alignment Length: 1090
• Identity: 272/1090 - (24%)
• Similarity: 440/1090 - (40%)
• Gaps: 359/1090 - (32%)

  Fly   453 DDEADIEIEIVEEE-----------PPFLSGHGRA-LHDLSP---------------VRIVKNPD 490
            |:|..|.:.|..|.           |..|:...|| :|.||.               ...||..|
  Rat    46 DEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKD 110

  Fly   491 GSLAQAAMMQSALSKERRE--QKMLQREQEIEAMPTSLNKNWIDPLP----------EDESRSLA 543
            ||....|||...|:...:.  :.::||      .|.: ||...:.||          |.|:|.::
  Rat   111 GSETAHAMMTCNLTHNTKHAVRSLIQR------FPVT-NKERTELLPKTERGNVFAVEAENREMS 168

  Fly   544 ANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVI 608
            .....:....|:||.              |:.:......|||||:::.:::::|.:.:|::::::
  Rat   169 KTSGRLNNGIPQVPV--------------KRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIV 219

  Fly   609 GETGSGKTTQITQY-LGEC---GFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRF 669
            |||||||||||.|: |.:|   |...|  |.||||||:||::||:|||.|...|:||.:||.||.
  Rat   220 GETGSGKTTQIPQFLLDDCFKNGIPCR--IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRL 282

  Fly   670 EDCTSPETIIKYMTDGMLLRECLM-EAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELK 733
            |...||:|::.:.|:|:|||..:. ::.|.:.:.:::||.|||...:|.|...|:..:||.|.||
  Rat   283 ESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLK 347

  Fly   734 LIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVL------------------YTKE-------- 772
            ||::||.||...|.:||...|:..|.||.|.|:.:                  |.||
  Rat   348 LILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQ 412

  Fly   773 ---------------PET-------------DYLD------ASLITVMQIHLREP---------P 794
                           ||:             |.||      .|.:|...::..||         .
  Rat   413 TTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACL 477

  Fly   795 GDILLFLTGQEEIDTACEILY---------------------------------ERMKSLGPDVP 826
            .||.|    .:::|...::.:                                 |::.|:|.:|.
  Rat   478 SDIWL----HKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVH 538

  Fly   827 E---------------------------------------------------------------- 827
            .
  Rat   539 SKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSF 603

  Fly   828 --------------------------LIILPVYS--------------------------ALPSE 840
                                      ||.||.|.                          .|.|.
  Rat   604 DDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSN 668

  Fly   841 MQT----RIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPIS 901
            |||    ::....|||.||::::|||||||:|::.:.:|:|.|.||:|.:::...:..|.:..||
  Rat   669 MQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWIS 733

  Fly   902 QAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDF 966
            :|:|.||.|||||..||..:||::...::: ||....||:.|..|....|..|.:...:....||
  Rat   734 KASAIQRKGRAGRCRPGICFRLFSRLRFQN-MLEFQTPELLRMPLQELCLHTKLLAPVNCTIADF 797

  Fly   967 -MDAP-PVESLVM--ALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEIL 1027
             |.|| |..:|::  |::.|.::.|:|....||.||..:|:.|:||:|.||::.:|.|:|.|.||
  Rat   798 LMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPIL 862

  Fly  1028 TIVSMLSVQNVFYRPKDKQALADQKKA------KFNQAE-GDHLTLLAVYNSW---KNNKFSNAW 1082
            ||...|:.::.|..|..    |.||:|      :|.... .||:.||..:.:|   :::.:..|:
  Rat   863 TIACTLAYRDPFVLPTQ----ASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAF 923

  Fly  1083 CYENFVQIRTLKRSQDVRKQLLG-------IMDRHKLDVVSAGKNSVR---IQKAICSGFFRNAA 1137
            |.:||:...|::....:|.||||       :..|...|:.....||..   ::.|:.:|.:.|..
  Rat   924 CEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLV 988

  Fly  1138 KKDPQEGYRTLVDSQVVYIHPSSALFNRQ------------------PEWVIYHELVQTTK-EYM 1183
            ..|.:....|....:.|..||:|.|...|                  .:|:||.|:.:..: ..:
  Rat   989 HVDRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANI 1053

  Fly  1184 REVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWR 1233
            |..:.:.|..::.|.       .|.:|:.           |..:||:::|
  Rat  1054 RCCSAVTPVTVLVFC-------GPARLTS-----------NALQEPSSFR 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	231/894 (26%)
Ythdc2	NP_001414131.1	None