DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and Dhx15

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001178526.1	Gene:	Dhx15 / 289693	RGDID:	1308072	Length:	795	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	370/795 - (46%)
Similarity:	503/795 - (63%)	Gaps:	79/795 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 IEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKER-REQKMLQREQEIEAMP 523
            :::.|:.|   ||..||           ..||...:....:...||:| ||:....||:|.|
  Rat     7 LDLGEDYP---SGKKRA-----------GTDGKDRERDRDREDRSKDRDRERDRGDRERERE--- 54

  Fly   524 TSLNKNWIDPLPEDESRSLAANMRGM---AAAPPEVPEWKKHVIGGKKSSFGKK----------- 574
                        :::.:.|.|:...|   |..||.......|......|:....
  Rat    55 ------------KEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHAG 107

  Fly   575 -----------TDL-------TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQ 621
                       |:|       .::::|..||:::.:|.....:..:|..:::|||||||||||.|
  Rat   108 HTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQ 172

  Fly   622 ----YLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYM 682
                |:.......|| :.|||||||||||||:|||:|....|||||||:||||||:|.:||:|||
  Rat   173 WCVEYMRSLPGPKRG-VACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYM 236

  Fly   683 TDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFS 747
            ||||||||.:.:..|:.|.||:||||||||:.||:|.|:||..|::|.:||:||.||||||.||.
  Rat   237 TDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQ 301

  Fly   748 QYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHL-REPPGDILLFLTGQEEIDTAC 811
            .||...|:.||||||.|||:.||.|||.|||:|::.||:|||: .|..||:|||||||||||.||
  Rat   302 IYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEAC 366

  Fly   812 EILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP------AGSRKVVIATNIAETSLTID 870
            :.:...:..|||:|.::.|:|:||.||.:.|.|||:|.|      |..||||::|||||||||||
  Rat   367 KRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTID 431

  Fly   871 GIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLP 935
            |:.:|:||||.||||||.:..::||:||.||:|:|:|||||||||.|||.:|||||:||:.||..
  Rat   432 GVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQD 496

  Fly   936 TPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRR 1000
            ...|||.|:||.:.|||||.:||:||:||||||.|..|:|:.|||.|:.|:||:|:|.||.||..
  Rat   497 NTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSM 561

  Fly  1001 MAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLT 1065
            ||||||:|.|:||:|.|....||:|:|:|.:||||...|.||.:.:..||:.|.:|...:|||||
  Rat   562 MAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLT 626

  Fly  1066 LLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNS----VRIQK 1126
            ||.||:::|.|..|..|||:||:..|:|..:.:||:||..||||..|...|....|    :.|:|
  Rat   627 LLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRK 691

  Fly  1127 AICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDP 1191
            |:.:|:|...|..:....|.|:.|:|||.:|||:.| :.:||||:|:|.|.|||.|:|..|.|.|
  Rat   692 ALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVL-DHKPEWVLYNEFVLTTKNYIRTCTDIKP 755

  Fly  1192 KWLVEFAPSFFRFSD 1206
            :|||:.||.::..|:
  Rat   756 EWLVKIAPQYYDMSN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	345/678 (51%)
Dhx15	NP_001178526.1	HrpA	124..763	CDD:224557	340/640 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730