DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and Dhx33

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	308/700 - (44%)
Similarity:	432/700 - (61%)	Gaps:	40/700 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 LPEDESRSLAANMRGMAAAPPEVPEWKKHVI-----------GGKK----------SSFGKKTDL 577
            :||:.....|...|     |...|..::.|:           ||::          |.:.:..:|
  Rat     1 MPEEAGLPPAKRFR-----PGSCPPGRRVVMLLTAGSGGGAGGGRRQTPPLAQPSASPYREALEL 60

  Fly   578 TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIGCTQPRRV 642
                ||:||||::.|..|:..:.:....::||||||||||||.|||.|.|.:.:|.|..||||||
  Rat    61 ----QRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRV 121

  Fly   643 AAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDE 707
            ||:|:|.||::|....||:.||||:||||.||.:|.||::||||||||.:.::.|:.||.::|||
  Rat   122 AAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDE 186

  Fly   708 AHERTIHTDVLFGLLKTAVQKRPE-----LKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEV 767
            |||||||||||||::|||.::|.|     ||:||.|||:|...|||||..||:..:.||..|:::
  Rat   187 AHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQI 251

  Fly   768 LYTKEPETDYLDASLITVMQIHLREPPG-DILLFLTGQEEIDTACEILYERMKSLGPDVPELIIL 831
            .|||:|:.|||.|:|::|.|||...|.. |||:||||||||:...:...:..|.|....|.:::|
  Rat   252 FYTKQPQQDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPSMLVL 316

  Fly   832 PVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLV 896
            |:|::||...|.|:|..||.|.|||:|:|||||||:||.||.||||.|.||.|.||..:|::.|.
  Rat   317 PLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLA 381

  Fly   897 VTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDL 961
            |..:|:..|.||.|||||...|..||||||..: |:......|||||.|||:.:|||..|.:.::
  Rat   382 VQRVSKTQAWQRTGRAGREDSGICYRLYTEDEF-DKFEKMAAPEIQRCNLASVMLQLLAMKVPNV 445

  Fly   962 LHFDFMDAPPVESLVMALEQLHSLSAL---DDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCS 1023
            |.||||..|..:.:..|:.||..|.||   ||:..||.:||:||.|||||..:|.:::|....|:
  Rat   446 LTFDFMSRPSPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCT 510

  Fly  1024 DEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFV 1088
            :|||||||:|||.:|.|.|..::......:.||..:||||:|||.:|.::||...:..||.||||
  Rat   511 EEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGNKDWCKENFV 575

  Fly  1089 QIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQV 1153
            ..:.:....:||.||..|..:..:.::|:..:...:::.:....|.:.|:..|...|.|....|.
  Rat   576 NSKNMLLVAEVRAQLRDICLKMSMPIMSSRGDMESVRRCLAHSLFMSTAELQPDGTYATTDTHQP 640

  Fly  1154 VYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFR 1203
            |.|||||.||:.:|..|:|..|:.|.|.|||::..:|.:||.|.||.:||
  Rat   641 VAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFR 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	297/639 (46%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	107/206 (52%)
		DEXDc	83..225	CDD:238005	85/141 (60%)
		Helicase_C	282..399	CDD:278689	59/116 (51%)
		HA2	469..554	CDD:214852	39/84 (46%)
		OB_NTP_bind	588..688	CDD:285018	33/99 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730