DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and prp16

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_595890.2	Gene:	prp16 / 2540006	PomBaseID:	SPBC1711.17	Length:	1173	Species:	Schizosaccharomyces pombe

Alignment Length:	1294	Identity:	478/1294 - (36%)
Similarity:	698/1294 - (53%)	Gaps:	226/1294 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVSKICTELDNHLGIND--KDLAEFIIDLENKNRTYDTFRKALLDNGAEFPDS---LVQNLQRII 71
            |.:|:..:|.:::...|  ..||..::.:...:.:...|..||...| .|.|:   |:.:|.:.|
pombe    10 LFTKLIDKLTDYMSSKDAATSLASRVLTIAKGSSSSTEFSNALHTFG-RFSDNDSVLIYDLCKSI 73

  Fly    72 -----NLMRPSRPGGASQEKTVGDK-----------------KEDKKSQLLKMFPGLALPNDTYS 114
                 ||       |.|::|..|:.                 :|.|||||     ||
pombe    74 IGLETNL-------GISKDKLPGNDGSQVAGLVLSNRSGLKGREPKKSQL-----GL-------- 118

  Fly   115 KKEESDDDEKVKAKPEKHSETHKKTDMSDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRS 179
                  |...|:.|.|| |:...::::|.|:..  .||::...:.....||.   :..::|.|..
pombe   119 ------DVLAVQKKKEK-SQVEGRSELSQVEND--SLESIGNYDRVEFKRPK---NPHEKHFRPL 171

  Fly   180 RDR---DTKRRSRSREDRHSDRRRS---------RSRDKERRRRSRSRDNRRRSRSREDRDRDRD 232
            |.|   |..:...|.:|::  ||.|         .|.:...|||.|::.....|..|.:|..:..
pombe   172 RQRSSVDDHQEFESEDDKY--RRNSYSSWSGSNFESSNGSNRRRYRTQMEEPLSSKRRNRFGNGS 234

  Fly   233 RRHKSSSSRDHHERRRRSRSRSTERRDRRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVP 297
            ||...||...|..........|.:.||         .:.|      .:|||:.
pombe   235 RRDVDSSKYSHDSDYSYGAHSSWDARD---------VEYP------EEDPESK------------ 272

  Fly   298 FGCFVQLFGLRKRW-EGLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQD 361
                    ..|:|| |...|:.                |:..:..:..::.|.:|.
pombe   273 --------ADRQRWEEEQAHLD----------------RDWYMNSESQNLLGDEVH--------- 304

  Fly   362 SGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSPERWEIKQ 426
                 ||.|    |.|::.||..:..|.....            :|.|.:...|......||..:
pombe   305 -----NPFS----DFETVEDRAHEAEFIEKQK------------KHLSIEASDRFKENSMWEKNR 348

  Fly   427 MISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDG 491
            ||:|||   |:.|..:.:..|:     :|..:.:.:.|..|.||.|...:...:..:..|::|..
pombe   349 MITSGV---SKAPGLESDYSLM-----EERRVHLLVDELRPHFLDGAEFSSKKVGDITSVRDPQS 405

  Fly   492 SLAQAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPE- 555
            .||..|.:.|.|.:||||   .:..|:..:..|||            :.:...|:.|:..:..|
pombe   406 DLAINARLGSRLVRERRE---FRERQKAASAATSL------------AGTSLGNVMGLKDSNDED 455

  Fly   556 -----VPEWKKHVIGGKKSSFGKKTDLTLV----EQRQSLPIYKLRDDLIKAVTDNQILIVIGET 611
                 .|   ..|.|..:.|..|.|:....    |||:.||.:.:|:.|:..:.|||:|||:|||
pombe   456 AKAGTTP---VKVAGRSEQSNKKDTEFARTKSYREQREFLPAFAVREQLLSVIRDNQVLIVVGET 517

  Fly   612 GSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPE 676
            |||||||:.|:|.|.|:...|.||||||||||||||||||:||.|.|||..|||:|||||.|.|:
pombe   518 GSGKTTQLAQFLYEDGYHRNGMIGCTQPRRVAAMSVAKRVSEEMGVRLGSTVGYSIRFEDVTGPD 582

  Fly   677 TIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATL 741
            |:|||||||:||||.||:..|:.||||::||||||:::||:|.||||..:.:|.::||:|||||:
pombe   583 TVIKYMTDGVLLRESLMQNNLEKYSVIIMDEAHERSLNTDILMGLLKKVLSRRRDIKLLVTSATM 647

  Fly   742 DAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEE 806
            ::.|||.:|..||.|||||||:||::::.|.|.:||::|::..|:||||.:|.||||:|:||||:
pombe   648 NSQKFSDFFGGAPQFTIPGRTYPVDIMFAKAPCSDYVEAAVRQVLQIHLSQPAGDILVFMTGQED 712

  Fly   807 IDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDG 871
            |:..|||:.:|:..| .|.|.|.|||:||.:|:::|.:|||.|..|.||||:||||||||||:.|
pombe   713 IEATCEIIADRLNQL-HDAPRLSILPIYSQMPADLQAKIFDSAEPGVRKVVVATNIAETSLTVHG 776

  Fly   872 IFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPT 936
            |.||||.|:.|.|:||||.|:|:|.|||||||.|.||||||||||||..||||||.||..||..|
pombe   777 ISYVVDTGYCKLKMYNSKLGIDTLQVTPISQANANQRAGRAGRTGPGIAYRLYTEMAYIREMFET 841

  Fly   937 PVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRM 1001
            .:||||||||:.|||.||::|:.::..|||||.||.::|:.:|.:|.:|.|||:.|.||.||::|
pombe   842 TLPEIQRTNLSNTVLILKSLGVEEISDFDFMDRPPNDTLMASLYELWTLGALDNFGKLTTLGKKM 906

  Fly  1002 AEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTL 1066
            :.||::|:|||::|::...:|::||:||||||||.:||||||::...:|..:.|||..|.|||.|
pombe   907 SLFPMDPSLSKLIIIAEDYKCTEEIITIVSMLSVPSVFYRPKERAEESDAAREKFNVPESDHLML 971

  Fly  1067 LAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSG 1131
            |.:|..|:.|.:||:||.::|:..:||||::|:|:||:.||.:.|:.:.|.....: :::.:||.
pombe   972 LNIYQHWQRNGYSNSWCSKHFLHSKTLKRARDIRQQLVEIMSKQKISLESVSDWDI-VRRVLCSA 1035

  Fly  1132 FFRNAAKKDPQEGYRTLVDSQVVYIHPSSALF--NRQPEWVIYHELVQTTKEYMREVTTIDPKWL 1194
            :|..||.......|..|......::|.:|:|:  ...|::|||||||.|:||||..||::||.||
pombe  1036 YFHQAACAKGIGEYVHLRSGMPCHLHVTSSLYGLGYLPDYVIYHELVLTSKEYMNIVTSVDPYWL 1100

  Fly  1195 VEFAPSFF----RFSDPTK------------------------LSKFKKNQRLEPLYNK 1225
            .||...::    ||.:.|:                        ..|..|||  ||:.:|
pombe  1101 AEFGGVYYSVKERFRNETESYDRVFSSKPQLDAQIAADRELDAKQKLAKNQ--EPVKSK 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	8/78 (10%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	347/681 (51%)
prp16	NP_595890.2	DEXDc	487..673	CDD:214692	117/185 (63%)
		DEXDc	509..647	CDD:238005	92/137 (67%)
		HELICc	718..821	CDD:197757	65/103 (63%)
		HA2	890..972	CDD:214852	42/81 (52%)
		OB_NTP_bind	998..1107	CDD:285018	42/109 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710