DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and Dhx37

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_017176254.1	Gene:	Dhx37 / 208144	MGIID:	3028576	Length:	1161	Species:	Mus musculus

Alignment Length:	1026	Identity:	302/1026 - (29%)
Similarity:	461/1026 - (44%)	Gaps:	237/1026 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 RNPDGPFSSSTSMLNLQGNGMEGDEHES--------RKRVTRISSPERWEIKQM------ISSGV 432
            :.|:.|    ...|.|:|..:.....||        ||:.|:...|.:.|.|.:      :...|
Mouse    22 KGPEAP----PVRLELEGKDVLKGVDESNVLVLPGKRKKKTKAPPPSKKERKPLTKKERKVLQKV 82

  Fly   433 LDRSEMPDFDEETGLLPK-DEDDEADIEIEIV---------------------------EEEPPF 469
            |::.|..  .:...||.| .|...::.|:.:.                           :|:...
Mouse    83 LEQKEKK--SQRAELLQKLSEVQVSEAEMSLFYTTAKLGTGDRMYHIKERKSGQPAARGQEKVSS 145

  Fly   470 LSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPL 534
            |||..|..|..|..    ..|...::.:..:.|.:.:.|..   ...:.:...|.....|...|.
Mouse   146 LSGAHRKRHRSSST----EEDSESSEDSEPEEATADQPRTS---TGTEPVHPPPAPSGINSPAPT 203

  Fly   535 PEDESRSLAANMRGMAAAPP-------------EVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSL 586
            |:.....::|..:..|:|||             ..||                    :.|:|..|
Mouse   204 PQPPPSGISAPPKTPASAPPPPVAKPAVFIPVNRTPE--------------------MQEERLKL 248

  Fly   587 PIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKR 650
            ||......:::||.::.|:||.||||||||||:.|:|.|.|:::... ||.|:||||||:::::|
Mouse   249 PILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQR 313

  Fly   651 VAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHT 715
            ||:|.... .:.|.|.||:|...:.||.||:||||:||:|...:..|..|.|:::||||||:::|
Mouse   314 VAKEMNLS-HRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYT 377

  Fly   716 DVLFGLLKTAVQKRPE----LKLIVTSATLDAVKFSQ----YFFKAPIFTIPGRTFPVEVLYTKE 772
            |:|.|||...|..|.:    |||::.||||....|:|    :....|:..:..|.|||.|.:.|.
Mouse   378 DILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVIKVESRQFPVTVHFNKR 442

  Fly   773 -PETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDTACEIL---------------------Y 815
             |..||.......|.:||...|.|.||:|||||.|:...|..|                     .
Mouse   443 TPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPFRCSQPQEKEEDSAEGM 507

  Fly   816 ERMK-------------------------------------------SLGPDV------------ 825
            .|.|                                           :||.|:
Mouse   508 RRFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALGSDLDLDLGDSEANEG 572

  Fly   826 --PE----LIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQK 884
              |:    |.:||:||.|..|.|.::|.|.|.|:|..|:|||:|||||||.||.||||.|.||::
Mouse   573 EQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 637

  Fly   885 VYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRD-EMLPTPVPEIQRTNLAT 948
            .|:..||:.|..||.:|||:|.|||||||||.||..||||:...:.| |..|.  |||.|..:..
Mouse   638 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPP--PEITRRPVED 700

  Fly   949 TVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALD----DEGL-----------LTRLG 998
            .:||:|.:.|..:::|.|...|.||:||.|.|.|.:|.||.    .|.:           :|.||
Mouse   701 LILQMKALSIEKVINFPFPTPPSVEALVAAEELLVALGALQAPPKQERMKKLQMSQLSCPITALG 765

  Fly   999 RRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFY---RP-KDKQALADQKKAKFNQA 1059
            |.|:.||:.|..:|||.:|....|....:.||:.::|:.:|.   || ..::.||:.|..:...|
Mouse   766 RTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEKELAELKGRRARVA 830

  Fly  1060 E--------------GDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQL------- 1103
            :              ||.:.||....:.:....|..:|..|.::.:.:...:.:|.||
Mouse   831 QMKRTWAGQGPSLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVNAV 895

  Fly  1104 ---LGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKK-------DP--QEGYRTLVDSQVVYI 1156
               .|:....|:...:..:.:. :::.:.:|...:.|::       ||  :..|:|.:....|:|
Mouse   896 CPEAGLFLDPKMQPPTESQVTY-LRQIMAAGLGDHLARRVQSEDLLDPKWKNAYKTPLLDDPVFI 959

  Fly  1157 HPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDP 1207
            ||||.||...||:|:|.|:|:|||.||:.|:|::.:|:....||:.:|..|
Mouse   960 HPSSVLFKELPEFVVYQEIVETTKMYMKGVSTVEIQWIPSLLPSYCQFDAP 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	260/780 (33%)
Dhx37	XP_017176254.1	HrpA	236..1009	CDD:224557	261/796 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820