DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and ddx-15

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	342/697 - (49%)
Similarity:	465/697 - (66%)	Gaps:	33/697 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   537 DESRSLAANMRGMAAAP--PEVPEWKKHV--IGGKKSSFGKKTD-------LTLVEQRQSLPIYK 590
            |..||.....|..:.:|  ...|:.|:.:  :|..|.......:       ..:.|:|..||:::
Worm    16 DRRRSPNRRSRSRSRSPHRRSSPDRKRQIGAVGNMKIQINPYNNQPFSNRYWAIWEKRSQLPVWE 80

  Fly   591 LRDDLIKAVTDNQILIVIGETGSGKTTQITQYL---------GECGFTARGKIGCTQPRRVAAMS 646
            .::..::.:.:||.:.::|||||||||||.|:.         |:....|| .:.|||||||||||
Worm    81 YKEKFMELLRNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQAR-LVACTQPRRVAAMS 144

  Fly   647 VAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHER 711
            ||.|||||....|||||||:||||||.|..|::||.||||||||.:....|..|.|::|||||||
Worm   145 VATRVAEEMDVVLGQEVGYSIRFEDCISERTVLKYCTDGMLLREAMNSPLLDKYKVLILDEAHER 209

  Fly   712 TIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETD 776
            |:.||:|.||:|..|:.|.::|:::.||||||.||.:||...|:.::||||||||:.:|...|.|
Worm   210 TLATDILMGLIKEIVRNRADIKVVIMSATLDAGKFQRYFEDCPLLSVPGRTFPVEIFFTPNAEKD 274

  Fly   777 YLDASLITVMQIHL-REPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSE 840
            ||:|::.||:|||: .|..|||||||||||||:.||:.:...:::||.|...|..:|:||.||..
Worm   275 YLEAAIRTVIQIHMVEEVEGDILLFLTGQEEIEEACKRIDREIQALGADAGALSCIPLYSTLPPA 339

  Fly   841 MQTRIFDPAP------AGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTP 899
            .|.|||:|||      |.|||.||:||||||||||||:.:|:||||.||||||.:..::||:|.|
Worm   340 AQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVIDPGFSKQKVYNPRIRVESLLVCP 404

  Fly   900 ISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHF 964
            ||:|:|.|||||||||.|||.:|||||.||..||.....|||.|:||.:.|||||.:|..||:||
Worm   405 ISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEILRSNLGSVVLQLKKLGTEDLVHF 469

  Fly   965 DFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTI 1029
            ||||.|..|:|:.|||.|:.|.|::|:|.||.||..||||||:|.|:||||.|..|.||:|||:|
Worm   470 DFMDPPAPETLMRALELLNYLQAINDDGELTELGSLMAEFPLDPQLAKMLITSTELNCSNEILSI 534

  Fly  1030 VSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLK 1094
            .:||||...:.||.:.:..||:.||:|...:|||||||.||:|:|.|:....|||:||:..||:|
Worm   535 TAMLSVPQCWVRPNEMRTEADEAKARFAHIDGDHLTLLNVYHSFKQNQEDPQWCYDNFINYRTMK 599

  Fly  1095 RSQDVRKQLLGIMDRHKLDVVSAGKNS----VRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVY 1155
            .:..||.||..:||::.|..||....|    :.|:||:.:|||...|..:....|.|:.|:|:|.
Worm   600 TADTVRTQLSRVMDKYNLRRVSTDFKSRDYYLNIRKALVAGFFMQVAHLERSGHYVTVKDNQLVN 664

  Fly  1156 IHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFF 1202
            :|||:.| :.:|||.:|:|.|.|||.::|.||.:.|:||::.||.::
Worm   665 LHPSTVL-DHKPEWALYNEFVLTTKNFIRTVTDVRPEWLLQIAPQYY 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	333/657 (51%)
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	15/64 (23%)
		DEXDc	70..266	CDD:214692	103/196 (53%)
		DEXDc	95..239	CDD:238005	80/144 (56%)
		HELICc	327..419	CDD:197757	56/91 (62%)
		HA2	489..572	CDD:214852	44/82 (54%)
		OB_NTP_bind	607..709	CDD:285018	41/102 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830