DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pea and ddx-35

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	692	Identity:	289/692 - (41%)
Similarity:	430/692 - (62%)	Gaps:	34/692 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 ESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDN 602
            |.||    .....||||...:.|.|        ......|.:.:||..|||:|.|..::......
Worm    41 EERS----TENAGAAPPIEEQLKVH--------NNPYASLNIQQQRIRLPIFKNRGHILYMCERY 93

  Fly   603 QILIVIGETGSGKTTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYT 666
            :.:|::||||.||:||:.|:|.|.|:.|.|: |..|||||||.:::|.|||||..|.||.:||||
Worm    94 RTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVGYT 158

  Fly   667 IRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPE 731
            :||:|.:..:|.:|:||||:||||.|.:..|..||:||:||||||:.:||:|.|||:..:|.|.:
Worm   159 VRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRND 223

  Fly   732 LKLIVTSATLDAVKFSQYF----------FKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVM 786
            |::||:||||||..|..:|          ..|.|.::.|||.||.|.:||....||..:::.||:
Worm   224 LRIIVSSATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAVHHTKTSVPDYCQSAVDTVI 288

  Fly   787 QIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPA 851
            .||..|.|||||:|||||:|::..||.|.|...:| .:...|.::|.|.|||:..|.:.||..|.
Worm   289 NIHKHENPGDILVFLTGQDEVEDVCEKLRELAGNL-KNCDRLWVVPCYGALPAREQMKAFDSTPH 352

  Fly   852 GSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTG 916
            |:||||:||||||.|:||.||.||:|.|:||.:..::..|:::|:...:|:|:|:||||||||..
Worm   353 GTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRAGRIR 417

  Fly   917 PGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQ 981
            |||.||||.|..: :......||||||..:|:|:||||.:|:.::..|.::..||..:::..||.
Worm   418 PGKCYRLYPESEF-ERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPPPSWAMINGLEL 481

  Fly   982 LHSLSALDDEGLLTR-LGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDK 1045
            |::|.|:|:...||. ||.:||||||.|..||.|:.|....||.|::|||:|:.:|:||..|..:
Worm   482 LYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPYRQ 546

  Fly  1046 QALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRH 1110
            :..||..:.||...||||:|:|.|:..:..|..|..||.::||..|.|.|:.:||.||:.::.|.
Worm   547 RHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRSKKWCSDHFVNYRGLMRADNVRSQLVRLLKRF 611

  Fly  1111 KLDVVSAG---KNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHP-SSALFNRQ-PEWV 1170
            :::.||:.   ..|..|::.:.:|||..||:......|.|:.:|....::. ||.:|.:. |:||
Worm   612 EIEKVSSRGLINCSENIRQCLVTGFFSQAAQYHYTGKYMTVKESFPFNMYKGSSIMFKKDYPKWV 676

  Fly  1171 IYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSK 1212
            |:.|::|   :.:|:||.|:|:||.|.||.::.|....:|::
Worm   677 IFTEVMQ---DSIRDVTVIEPEWLYELAPHYYEFGTEGELAE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	280/657 (43%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	275/636 (43%)
		DEXDc	96..233	CDD:238005	74/136 (54%)
		Helicase_C	284..416	CDD:278689	65/132 (49%)
		HA2	484..568	CDD:214852	38/83 (46%)
		OB_NTP_bind	602..704	CDD:285018	34/104 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730