DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and mog-4

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_497027.1	Gene:	mog-4 / 175117	WormBaseID:	WBGene00003392	Length:	1008	Species:	Caenorhabditis elegans

Alignment Length:	1239	Identity:	462/1239 - (37%)
Similarity:	670/1239 - (54%)	Gaps:	271/1239 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLVSKICTELDNHLGINDKDLAEFIIDLENKNRTYDTFRKALLDNGAEFP---------DSLVQ 65
            :|:...|..:|.:.:||:|:.:.:::..|..|.::.....:.|.|.| :||         |.|:.
Worm     1 MSVEQFINDQLHSIVGISDRSICQYVHALAKKAKSAPDLVEKLRDAG-DFPISPAIQSFADQLMS 64

  Fly    66 NLQRIINLMRPSRPGGASQEKTVGDKKEDKKSQL------LKMFPGLALPNDTYSKKEES---DD 121
            .:.|.....|...|       |..:..|.:.::|      |:.:...:.......|::||   ||
Worm    65 RMPRQATSARQRGP-------TTAELAEQELNRLNRAVGVLEDYSASSTKTKNVRKRKESSSEDD 122

  Fly   122 DEKVKA-KPEKHSETHKKTDM-SDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRSRDRDT 184
            :..:|| ||.|..:..|..|. ||::|...:|:|              :::.||....|...::
Worm   123 EAPIKASKPGKSVKPSKSDDSESDIEAMEAKLDA--------------DIAERDALAARINKKE- 172

  Fly   185 KRRSRSREDRHSDRRRSRSRDKERRRRSRSR-DNRRRSRSREDRDRDRDRRHKSSSSRDHHERRR 248
                               :||.|....:.| ||:.:..|..|:.|:..|       |.:.::|:
Worm   173 -------------------KDKTRNVMEKKRDDNKDKEGSSMDKLREESR-------RQYLKKRK 211

  Fly   249 RSRSRSTERRDRRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLRKRWEG 313
            ..:....|.....|::....||       :|...:|...|..|:
Worm   212 VDKLEELEAIVHDDQTLFAREK-------LTKREKADMEYRKKV--------------------- 248

  Fly   314 LVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSGKDLNPLSHAPEDDES 378
               :...:|.|:..||         :|:|...:.    ..|.|::         |..:..:|:|.
Worm   249 ---LEYTKAHGKAGDV---------MKMKRYHLP----DASTKQI---------PSQYVEDDEED 288

  Fly   379 LRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSPERWEIKQMISS----GVLDRSEMP 439
            .|   |.|                :|               .:||.:|:::|    |..|
Worm   289 FR---PGG----------------DG---------------AKWEEEQLMASMLHLGAKD----- 314

  Fly   440 DFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALS 504
                     .|.::.|.::   :::|:..|:                              .||.
Worm   315 ---------AKRKEQEFEL---LLDEKVDFI------------------------------QALQ 337

  Fly   505 KERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKS 569
            .....:::::.|.|
Worm   338 MPGTNEEVVETEAE--------------------------------------------------- 351

  Fly   570 SFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK- 633
                |..:::.|.|:|||:|..||..|:||.::|:||:.||||||||||:.|||.|.||...||
Worm   352 ----KKKMSIEETRKSLPVYAFRDAFIEAVKEHQVLIIEGETGSGKTTQLPQYLYEAGFCEGGKR 412

  Fly   634 IGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELK 698
            |||||||||||||||.|||:|.||:||.:|||:||||||||.:|::|||||||||||.|.|.:|.
Worm   413 IGCTQPRRVAAMSVAARVADEVGCKLGTQVGYSIRFEDCTSEKTVLKYMTDGMLLREFLNEPDLA 477

  Fly   699 SYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTF 763
            ||||:|:|||||||:|||:||||:|...:.|.:|||:::||||||.|||.:|..||||.||||.|
Worm   478 SYSVMMIDEAHERTLHTDILFGLVKDIARFRKDLKLLISSATLDAEKFSSFFDDAPIFRIPGRRF 542

  Fly   764 PVEVLYTKEPETDYLDASLITVMQIHLREP-PGDILLFLTGQEEIDTACEILYERMKSLGPDVPE 827
            ||::.||:.||.||:||:::|:|||||.:| |||||:||||||||:|..|.|.||.|:||..:.|
Worm   543 PVDIYYTQAPEADYVDAAIVTIMQIHLTQPLPGDILVFLTGQEEIETVQEALMERSKALGSKIKE 607

  Fly   828 LIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGM 892
            ||.||||:.|||::|.:||:|.|..:||||:||||||||:|||||.||:||||.||..:::::|:
Worm   608 LIPLPVYANLPSDLQAKIFEPTPKDARKVVLATNIAETSVTIDGINYVIDPGFSKQNSFDARSGV 672

  Fly   893 DSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMG 957
            :.|.|..||:|||.|||||||||||||.:||||..||:.|:...|:||||||||...||.||::|
Worm   673 EHLHVVTISKAAANQRAGRAGRTGPGKCFRLYTAWAYKHELEEQPIPEIQRTNLGNVVLMLKSLG 737

  Fly   958 INDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQC 1022
            |:||:||||:|.||.|:||:|||||::|.||:..|.||:|||||||||.:|.:|||:|.|...:|
Worm   738 IHDLVHFDFLDPPPQETLVIALEQLYALGALNHRGELTKLGRRMAEFPCDPCMSKMIIASEKYEC 802

  Fly  1023 SDEILTIVSMLSVQ-NVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYEN 1086
            |:||:||.:|||.. .||||||.:...||..:..|....|||:||:.|||.|:.:.||..||.||
Worm   803 SEEIVTIAAMLSCNAAVFYRPKAQVIHADSARKGFWSPAGDHITLMNVYNKWQESSFSQRWCVEN 867

  Fly  1087 FVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDS 1151
            :||.||:||::|||.||:|:::|.:::..|: .::::|:|||.:|:|.|.:|.|....|:|:...
Worm   868 YVQHRTMKRARDVRDQLVGLLERVEIETKSS-TDTIKIRKAITAGYFYNVSKLDNTGHYKTVKHK 931

  Fly  1152 QVVYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFR---FSDPTKLSKF 1213
            ...:.||:|.||...|.||:|.|||.|:||:|||::.|:..||:|.||.:::   ..|.|. .|.
Worm   932 HTTHPHPNSCLFEETPRWVVYFELVFTSKEFMREMSEIESGWLLEVAPHYYKGRELEDATN-KKM 995

  Fly  1214 KKNQ 1217
            .||:
Worm   996 PKNK 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	10/77 (13%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	371/651 (57%)
mog-4	NP_497027.1	DTHCT	<103..162	CDD:285332	17/72 (24%)
		DEXDc	370..546	CDD:214692	120/175 (69%)
		DEXDc	381..520	CDD:238005	96/138 (70%)
		Helicase_C	577..696	CDD:278689	74/118 (63%)
		HA2	764..848	CDD:214852	43/83 (52%)
		OB_NTP_bind	872..981	CDD:285018	47/109 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830