Protein Alignment pea and ythc-2

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_492260.1
• Gene: ythc-2 / 172615
• WormBaseID: WBGene00009922
• Length: 1425
• Species: Caenorhabditis elegans
• Alignment Length: 1179
• Identity: 266/1179 - (22%)
• Similarity: 441/1179 - (37%)
• Gaps: 413/1179 - (35%)

  Fly   384 PDGPFSSSTSMLNLQGNGME-------GDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDF 441
            |.|.|...........||.:       |.::::||...|:::.   .|:..:.||
 Worm     5 PPGFFRGGVDSKRCSRNGFDASRVLPRGTDNDTRKEYRRVANE---IIRSFLKSG---------- 56

  Fly   442 DEETGLLPKDEDDEADI-EIEIVEEEPPFLSGHGRALHDLSPVR--IVKNPDGSLAQAAMMQS-- 501
            .:.|.|.|...|....: |:.::.|..  ...|||     .|.|  |:......|:::.::.:
 Worm    57 QKNTTLEPMGRDQRKVMHEVALLNEMT--TKSHGR-----EPDRYMILSKRVNRLSKSTLVATEP 114

  Fly   502 ------ALSKERR--EQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPE 558
                  .|.|..:  |:..:.||:..|.:..:..|         :..:...::......||
 Worm   115 ITPSFECLQKLSKFVEKHPITREEMDEFLTETQTK---------QMHTTKGHISDRMVIPP---- 166

  Fly   559 WKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQY- 622
                     ||...|:    |.:.|.|||..|..|.::|:::...::|:.|.||.|||||:.|:
 Worm   167 ---------KSKCSKE----LQKVRNSLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQFI 218

  Fly   623 LGECGFTARG-KIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGM 686
            |.|.....:. ::..|||||:||:|:|:|||.|.|..:|:.|||.:|.:...|.:|::.|.|.|:
 Worm   219 LDEAHENNKHVRVMVTQPRRIAAISIAERVARERGEPIGRTVGYQVRLDSRRSDDTVLTYCTTGV 283

  Fly   687 LLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDA--VKFSQY 749
            |||....:......:.|::||.|||.|:||.|...|:..::.||:||:|:.|||::.  ..||.|
 Worm   284 LLRMLTSDPVASGITHIVMDEIHEREINTDYLLIALRECLKMRPDLKVILMSATIEGNMQLFSNY 348

  Fly   750 F--FKAPIFTIPGRTFPVEVLY------------------------------------------- 769
            |  ....:..|..|.|.|:|.|
 Worm   349 FENHSMDVIRIESRAFDVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVEREEKDK 413

  Fly   770 ----------------------------------------------------------------- 769
                                                                             
 Worm   414 AKQRAADSSLSTLSKPVTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNIIGNPDI 478

  Fly   770 -----------------------------------------------------------TKEP-- 773
                                                                       ||.|
 Worm   479 RPVITVEFRPTTPNSVFINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTTKSPPS 543

  Fly   774 ----------------------------------------------------------ETDY--- 777
                                                                      :||:
 Worm   544 PTPTLGISSGLAKFTPFGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKTDFSKL 608

  Fly   778 -----------------LDASLITVMQIHLREPP--GDILLFLTGQEEIDTACEILYERMKSLGP 823
                             :|..|:..:..:|.:.|  |.||:||.|.|:|....:.: :..|:...
 Worm   609 RFGEKYNLFYGSSSNNSVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAI-DCWKNSLK 672

  Fly   824 DVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNS 888
            ::..:|:||::|.:.|.....||...|..:||:::||||||.|:||:.:.:|||.|.||:|.::.
 Worm   673 NMKNVIVLPLHSQMTSINHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVKEKSFDH 737

  Fly   889 KTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQL 953
            :..:.:|.|.||:::.|.||:|||||...|...|||||:.| :.|..|.:.|::|..:....|..
 Worm   738 EAKLSTLTVKPIARSNADQRSGRAGRVANGYCIRLYTEQEY-NSMPETQIAEMKRAAIYDVTLHA 801

  Fly   954 KTMGINDLLHFDFM----DAPPVESLVMALEQLHSLSAL-----------DDEGL---------- 993
            |......|...:|:    :.|..||::.|:..|..:.|.           ::|||
 Worm   802 KLFAPKTLKISEFLSLAPEPPEKESILQAITFLEQIGAFYTPIKIYDNSGNEEGLKNDEEAENSE 866

  Fly   994 ------LTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALAD-- 1050
                  ||.|||.||..||:|.||:||:..:||:|...|:.:|::|:.:..:.     .||::
 Worm   867 NPEDPELTDLGRLMARLPLDPQLSRMLLFGLALKCLTPIVNLVALLASREPYV-----LALSEDR 926

  Fly  1051 --QKKAKFNQAE---GDHLTLLAVYNSW--KNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMD 1108
              |.|.||..|:   .|||..:.:.|.:  |||...|.:|.::|:...|::..|..|:|||..:.
 Worm   927 DLQSKMKFEMAQQDLSDHLLYIRLCNEFCSKNNSQQNQFCRDHFLNFSTMRMVQGTRRQLLRELV 991

  Fly  1109 RHKLDVVSAGKNSV----------------RIQKAICSG---FFRNAAKKDPQEGYRTLVDSQVV 1154
            |.||..:|..::.:                .||..|.:|   |...:|.:...:..:|..| :..
 Worm   992 RAKLINISPNRDVLTVLTDHHFNQFSQCWPMIQAVIAAGCYPFIGVSASESNLKKVQTFND-KPA 1055

  Fly  1155 YIHPSSAL---------FNRQP--EWVIYHELVQTTKE---YMREVTTIDPKWLVEFAPSF--FR 1203
            ::||||.:         ..:.|  |:|.:.|:.|...:   .|:.||.|         ||.  ..
 Worm  1056 FLHPSSMVKKQIVKMGKSEKSPRVEYVAFQEMCQMPSDRSLSMKTVTVI---------PSMTALL 1111

  Fly  1204 FSDPTKLSK 1212
            |:.|.:|.:
 Worm  1112 FTGPIRLDE 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	226/954 (24%)
ythc-2	NP_492260.1	R3H	21..100	CDD:214647	21/98 (21%)
		DEXHc_RHA-like	198..359	CDD:438707	62/160 (39%)
		HrpA	<630..>988	CDD:441249	116/364 (32%)
		OB_NTP_bind	1023..1116	CDD:400182	24/102 (24%)