DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and let-355

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	931	Identity:	290/931 - (31%)
Similarity:	445/931 - (47%)	Gaps:	161/931 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 EVDQDSGKDLNPLSHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSPER 421
            ::|:| ||.:.|              ||....|..     ||...:.|:..::..:..:..:.|.
Worm    18 QIDKD-GKKIKP--------------NPGAQISKI-----LQNGKVNGNSRQTGGQEQKFQNLEA 62

  Fly   422 WEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIV 486
            .:.|.|:..  ..:.:|.:|.:|..||.                               |..||.
Worm    63 LKKKTMLLK--KKKKQMNNFQKEEELLS-------------------------------STFRIT 94

  Fly   487 KNPDGSLAQAAMMQSALSKERREQKMLQREQEIEA------MPTSLNKNWIDPLPEDESRSLAAN 545
            ..                       :|::|::||.      .|..|.|..|. .|.:...:...:
Worm    95 NG-----------------------ILKKEKKIEVTTISTQTPKKLPKTPIS-TPSNSKNATPMS 135

  Fly   546 MRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGE 610
            .|..:::....|.::.:.   :|.|            |..|||..:...|:..:...:.||||||
Worm   136 TRKHSSSQQSPPHFEANY---EKFS------------RPQLPIDAVEQQLMYELASQETLIVIGE 185

  Fly   611 TGSGKTTQITQYLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSP 675
            |||||:||:.|.....|....|.|..||||||||:|:|.|||.|.|..:|..|||.:|||:.|..
Worm   186 TGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGYHVRFENATCH 250

  Fly   676 ETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPE----LKLIV 736
            :|.|:|||||::||:.|:...|..||.:::||||||::|:|||..:|:....:|.|    |:||:
Worm   251 KTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRETNNPLRLII 315

  Fly   737 TSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKE------PETDYLDASLITVMQIHLREPPG 795
            .||||.|.||..||..|.:..:.|||||:||.:...      ..|||:..::|.|..:||.||.|
Worm   316 MSATLQAEKFQSYFNNAKVVLVAGRTFPIEVFHVNPKINKSFSSTDYVYNAVICVKYVHLTEPKG 380

  Fly   796 -DILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIA 859
             |||:||||.|||:.....|.|...||......|:.:|:|:||..|.|...|...|.|:|||:|:
Worm   381 RDILVFLTGSEEIEAVASQLAELNGSLPASADVLMPVPLYAALRPEKQKEAFRKTPQGARKVIIS 445

  Fly   860 TNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLY 924
            |||||||:||.||..|:|.|.||.|.:.:...:|.|.|..:|:|.||||||||||..|||.||||
Worm   446 TNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVSKAQAKQRAGRAGRDAPGKCYRLY 510

  Fly   925 TERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSAL- 988
            :...:. :.....:|||.|.||:.|.|:|..:|:.:......:|.|..:::..||.:|.||.|:
Worm   511 SREDFH-KFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDNINAALLELTSLGAIR 574

  Fly   989 ---DDEG--LLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQAL 1048
               .|..  .||.:|.....:||.|:.:::|..:....|..|.:.||:.:....:|....|.::.
Worm   575 PVNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSGAGDSKSD 639

  Fly  1049 A--DQKKAKFNQAEGDHLTLL---AVYNSW-----------------------KNNKFSNAWCYE 1085
            |  |:.:.:|...||||:|||   .|.|.:                       :.|:....:|.:
Worm   640 ADVDRIRRRFETREGDHITLLKLVLVTNQFFDQLNKKTESDARYGKANKSLEREYNQTIRKFCND 704

  Fly  1086 NFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEG-YRTLV 1149
            |.:..:.||.:..:.:||..|....|:...:.|.:.::::||:..|.|.|:.:.|.||. ||.::
Worm   705 NMINEQHLKTASMIEEQLKQIAIEQKVTFSTCGADFMKMRKALALGMFLNSCEYDRQEDRYRLMI 769

  Fly  1150 DSQV-VYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKL--- 1210
            :..: :.|||||.|...:|.::::.||::|...:..:||.||..|:...      .||..|:
Worm   770 NPAITLKIHPSSCLSRSKPAYIVFSELMKTNDLFALQVTLIDGDWVRPL------ISDHKKMRAN 828

  Fly  1211 ------SKFKKNQRLEPLYNK 1225
                  .:.::..||||...|
Worm   829 HLAETTERVQQITRLEPKAKK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	2/5 (40%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	252/703 (36%)
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	243/666 (36%)
		DEXDc	180..320	CDD:238005	71/139 (51%)
		Helicase_C	383..500	CDD:278689	57/116 (49%)
		HA2	569..660	CDD:214852	25/90 (28%)
		OB_NTP_bind	712..822	CDD:285018	33/115 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830