DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and DHX15

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001349.2	Gene:	DHX15 / 1665	HGNCID:	2738	Length:	795	Species:	Homo sapiens

Alignment Length:	816	Identity:	373/816 - (45%)
Similarity:	503/816 - (61%)	Gaps:	94/816 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 LDRSE-MPDFDEETGLLPKDEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQA 496
            ||..| .|...:..|...||.|.:.|.|                   |.|..|..:...|
Human     7 LDLGEDYPSGKKRAGTDGKDRDRDRDRE-------------------DRSKDRDRERDRG----- 47

  Fly   497 AMMQSALSKERREQKMLQREQEIEAMPTS-LNKNWIDPLPEDES----------------RSLAA 544
                   .:||..:|  ::|:|:.|...: |....:.||....|                .|..|
Human    48 -------DREREREK--EKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHA 103

  Fly   545 NMRGMAAAP---------PEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVT 600
            ...|..:.|         |..|.:                 ..::::|..||:::.:|.....:.
Human   104 GHAGHTSLPQCINPFTNLPHTPRY-----------------YDILKKRLQLPVWEYKDRFTDILV 151

  Fly   601 DNQILIVIGETGSGKTTQITQ----YLGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQ 661
            .:|..:::|||||||||||.|    |:.......|| :.|||||||||||||:|||:|....|||
Human   152 RHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRG-VACTQPRRVAAMSVAQRVADEMDVMLGQ 215

  Fly   662 EVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAV 726
            ||||:||||||:|.:||:|||||||||||.:.:..|:.|.||:||||||||:.||:|.|:||..|
Human   216 EVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVV 280

  Fly   727 QKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHL- 790
            ::|.:||:||.||||||.||..||...|:.||||||.|||:.||.|||.|||:|::.||:|||:
Human   281 RQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMC 345

  Fly   791 REPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP----- 850
            .|..||:|||||||||||.||:.:...:..|||:|.::.|:|:||.||.:.|.|||:|.|
Human   346 EEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQN 410

  Fly   851 -AGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGR 914
             |..||||::||||||||||||:.:|:||||.||||||.:..::||:||.||:|:|:||||||||
Human   411 GAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGR 475

  Fly   915 TGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMAL 979
            |.|||.:|||||:||:.||.....|||.|:||.:.|||||.:||:||:||||||.|..|:|:.||
Human   476 TRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRAL 540

  Fly   980 EQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKD 1044
            |.|:.|:||:|:|.||.||..||||||:|.|:||:|.|....||:|:|:|.:||||...|.||.:
Human   541 ELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTE 605

  Fly  1045 KQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDR 1109
            .:..||:.|.:|...:|||||||.||:::|.|..|..|||:||:..|:|..:.:||:||..||||
Human   606 AKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDR 670

  Fly  1110 HKLDVVSAGKNS----VRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWV 1170
            ..|...|....|    :.|:||:.:|:|...|..:....|.|:.|:|||.:|||:.| :.:||||
Human   671 FNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVL-DHKPEWV 734

  Fly  1171 IYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSD 1206
            :|:|.|.|||.|:|..|.|.|:|||:.||.::..|:
Human   735 LYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	343/649 (53%)
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		26/133 (20%)
		HrpA	124..763	CDD:224557	341/657 (52%)
		DEAH box	260..263		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730