DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and DHX9

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001348.2	Gene:	DHX9 / 1660	HGNCID:	2750	Length:	1270	Species:	Homo sapiens

Alignment Length:	1132	Identity:	274/1132 - (24%)
Similarity:	469/1132 - (41%)	Gaps:	285/1132 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 GKIANIVPFGCFVQLFGLRKRWEGLVHISQLRAEGRVTDVTEVVTRNQ-----TVKVKVMSITGQ 349
            |.:.|.:...|     |.||    :....::||.|         .:|:     .|:|:..:.||.
Human     2 GDVKNFLYAWC-----GKRK----MTPSYEIRAVG---------NKNRQKFMCEVQVEGYNYTGM 48

  Fly   350 KVSLSMKEVDQDSGKD-------LN----------------PLSHAPEDDESLRDRNP---DGPF 388
            ..|.:.|:...::.:|       :|                ||:..|:...:.....|   .||.
Human    49 GNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPL 113

  Fly   389 -------SSSTSMLNLQGNGMEG---------DEHESRKRVTRISSPERWEIKQMISSGVLD--- 434
                   :.:.|.:...|.|:.|         .::.|||        |..|::..:.|..:|
Human   114 PPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRK--------EEQEVQATLESEEVDLNA 170

  Fly   435 -----------RSEMPDFDEETGL--------LPKDEDDEADIEIEIVEEE---PPFLSGHG--- 474
                       ::.:..:.::..:        :..|.:.....|:.|..::   ..|...||
Human   171 GLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNK 235

  Fly   475 ------------RALHDLSPVR----IVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMP 523
                        |.|:.|..|.    :.|..:|...:...:..:...|.:.|.::| |..:|.:|
Human   236 KLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQ-ELNLEILP 299

  Fly   524 TSLNKNWIDPLPEDESRSLAANMRGMAA---------------APPEV---PEWKKHVIGG---- 566
            .          |||.|..:|.|:..:|.               :||:.   |....::..|
Human   300 P----------PEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAF 354

  Fly   567 ---KKSSFGKKTDL-----------TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTT 617
               ::.|...|.:|           .::::|:.||:.|...::::|::.|.::|:.|.||.||||
Human   355 ATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTT 419

  Fly   618 QITQYL----------GECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFED- 671
            |:.|::          .||      .|..|||||::|:|||:|||.|.|...|:..||::|||.
Human   420 QVPQFILDDFIQNDRAAEC------NIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESI 478

  Fly   672 CTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIV 736
            ...|...|.:.|.|:|||:  :||.::..|.:::||.|||.|:||.|..:|:..||..||:::::
Human   479 LPRPHASIMFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVL 541

  Fly   737 TSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKE-----------------------PETDYL 778
            .|||:|...|.:|||..||..:.|||:||:..:.::                       .|.|..
Human   542 MSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDA 606

  Fly   779 DASLI-----------TVMQIHLREP-----------------PGDILLFLTGQEEIDTACEILY 815
            :.:||           ::.|::.:|.                 ||.:|:||.|       ..::|
Human   607 NCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPG-------WNLIY 664

  Fly   816 ERMKSLGPDVPEL-----IILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYV 875
            ...|.|..: |..     .|||::|.:|.|.|.::|||.|.|..||:::|||||||:||:.:.||
Human   665 TMQKHLEMN-PHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYV 728

  Fly   876 VDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPV-P 939
            :|....|.|::.:...|.:......|:...:||.|||||..||..:.| ..|| |.|.|.|.: |
Human   729 IDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHL-CSRA-RFERLETHMTP 791

  Fly   940 EIQRTNLATTVLQLKTMGINDLLHF--DFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMA 1002
            |:.||.|....|.:|.:.:..:..|  ..::.||:::::.|...|..|.|||....||.|||.:|
Human   792 EMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILA 856

  Fly  1003 EFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKA--KFNQAEGDHLT 1065
            :.|:||...||:||.......|.|.||.:.......|.....:.....:..|  :|:    ||:.
Human   857 KLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFS----DHVA 917

  Fly  1066 LLAVYNSWKNNKFSN-----AWCYENFVQIRTLKRSQDVRKQLLGIM------------------ 1107
            ||:|:.:|.:.:...     .:|....:.:.||:.:.:.:.||..|:
Human   918 LLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNT 982

  Fly  1108 -DRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVI 1171
             ..:.|||| ....:..:...:|  :.:...|....||...|:....|....||........:.:
Human   983 GPDNNLDVV-ISLLAFGVYPNVC--YHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFV 1044

  Fly  1172 YHELVQTTKEYMREVTTIDPKWLVEFA 1198
            :.|.::|.....:.:|.:.|..|:.||
Human  1045 FGEKIRTRAISAKGMTLVTPLQLLLFA 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	16/77 (21%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	209/733 (29%)
DHX9	NP_001348.2	Interaction with CREBBP. /evidence=ECO:0000269\|PubMed:9323138	1..250		42/273 (15%)
		DSRM	5..69	CDD:214634	16/81 (20%)
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYY	5..9		1/3 (33%)
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYY	53..55		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..118		6/34 (18%)
		DSRM	181..251	CDD:214634	7/69 (10%)
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYX	182..186		0/3 (0%)
		Interaction with BRCA1. /evidence=ECO:0000269\|PubMed:9662397	230..325		21/105 (20%)
		siRNA-binding. /evidence=ECO:0000305\|PubMed:23361462	234..236		0/1 (0%)
		Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269\|PubMed:9323138	255..664		113/434 (26%)
		Necessary for interaction with H2AX. /evidence=ECO:0000269\|PubMed:15613478	313..952		193/660 (29%)
		MTAD. /evidence=ECO:0000269\|PubMed:11416126	331..380		7/48 (15%)
		HrpA	381..1095	CDD:224557	207/716 (29%)
		Core helicase. /evidence=ECO:0000305\|PubMed:25062910	398..809		143/428 (33%)
		DEIH box	511..514		2/2 (100%)
		Nuclear localization signal (NLS1). /evidence=ECO:0000255	586..595		0/8 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..608		2/19 (11%)
		HA2. /evidence=ECO:0000269\|PubMed:25062910	831..919		28/91 (31%)
		OB-fold. /evidence=ECO:0000269\|PubMed:20696886, ECO:0000269\|PubMed:25062910, ECO:0000269\|PubMed:25149208	958..1074		22/117 (19%)
		RGG. /evidence=ECO:0000269\|PubMed:10207077, ECO:0000269\|PubMed:25062910, ECO:0000269\|PubMed:25149208, ECO:0000269\|PubMed:9111062	1150..1270
		Nuclear localization signal (NLS2). /evidence=ECO:0000269\|PubMed:16375861	1155..1173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1229..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810