Protein Alignment pea and DHX8

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Alignment Length: 1256
• Identity: 880/1256 - (70%)
• Similarity: 1010/1256 - (80%)
• Gaps: 71/1256 - (5%)

  Fly     2 DELQKLEYLSLVSKICTELDNHLGINDKDLAEFIIDLENKNRTYDTFRKALLDNGAEFPDSLVQN 66
            :||.||||||||||:||||||||||||||||||:|.|..||.|:|||:.:|:.|||||.|||:.|
Human    20 EELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISN 84

  Fly    67 LQRIINLMRPSRPGGASQEKTVGDKKEDKKSQLLKMFPGLALPNDTYSKKEESDDDEKVKAKPEK 131
            |.|:|..|||......|::..|..|.|  |.:|.::||.|..|::...:....:||.||.
Human    85 LLRLIQTMRPPAKPSTSKDPVVKPKTE--KEKLKELFPVLCQPDNPSVRTMLDEDDVKVA----- 142

  Fly   132 HSETHKKTDMSDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRSRDRDTKRRSRSREDRHS 196
                        || .:.|||||.|.......:...|...|.:.|:|||.||..|      ||..
Human   143 ------------VD-VLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNR------DRDR 188

  Fly   197 DRRRSRSRDKERRRRSRSRDNRRRSRSREDRDRDRDRRHKSSSSRDHHERRRRSRSRS----TER 257
            ||.|:|.||.:||.|||||.   |||:||        |:|..|       |.||||||    .:|
Human   189 DRERNRDRDHKRRHRSRSRS---RSRTRE--------RNKVKS-------RYRSRSRSQSPPKDR 235

  Fly   258 RDR-------RDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLRKRWEGLV 315
            :||       .||.||.....|||     ::|..|.||:||:.:|:.|||||||.||||||||||
Human   236 KDRDKYGERNLDRWRDKHVDRPPP-----EEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLV 295

  Fly   316 HISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSGKDLNP---LSHAPEDDE 377
            |||:||.||||.:|.:||::.|.|||||:|.||.|.|||||:|||::|:||||   .:...|.:|
Human   296 HISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 360

  Fly   378 SLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFD 442
            ....||||.|    |.:..:....:|.|..| |||:||||.||:|||||||::.||.:.|.||||
Human   361 ETSMRNPDRP----THLSLVSAPEVEDDSLE-RKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 420

  Fly   443 EETGLLPK--DEDDEADIEIEIVEEEPPFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSK 505
            ||||:|||  ||:|| |:|||:||||||||.||.:...|:||::|||||||||:|||||||||:|
Human   421 EETGILPKVDDEEDE-DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAK 484

  Fly   506 ERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSS 570
            ||||.|..|||.|::::|..|||:|:||||:.|.|.:||||||:...|.::||||||..||.|:|
Human   485 ERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKAS 549

  Fly   571 FGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGKIG 635
            :||||.::::|||:|||||||::.|::||.|||||||||||||||||||||||.|.|:|:|||||
Human   550 YGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIG 614

  Fly   636 CTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSY 700
            ||||||||||||||||:||:||.|||||||||||||||||||:||||||||||||||::.:|..|
Human   615 CTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQY 679

  Fly   701 SVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTFPV 765
            ::|||||||||||||||||||||..||||.::||||||||||||||||||::||||||||||:||
Human   680 AIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV 744

  Fly   766 EVLYTKEPETDYLDASLITVMQIHLREPPGDILLFLTGQEEIDTACEILYERMKSLGPDVPELII 830
            |:|||||||||||||||||||||||.|||||||:|||||||||||||||||||||||||||||||
Human   745 EILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELII 809

  Fly   831 LPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSL 895
            ||||||||||||||||||||.|||||||||||||||||||||:||||||||||||||||||:|.|
Human   810 LPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQL 874

  Fly   896 VVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGIND 960
            ||||||||.|||||||||||||||.||||||||||||||.|.||||||||||:|||.||.|||||
Human   875 VVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGIND 939

  Fly   961 LLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDE 1025
            ||.||||||||:|:|:.|:|||::|.||||||||||||||||||||||.|.|||||||.|.||:|
Human   940 LLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEE 1004

  Fly  1026 ILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNKFSNAWCYENFVQI 1090
            :||||||||||||||||||||||||||||||:|.|||||||||||||||||||||.||||||:|.
Human  1005 MLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQA 1069

  Fly  1091 RTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQVVY 1155
            |:|:|:||:|||:|||||||||||||.||::||:||||||||||||||||||||||||:|.||||
Human  1070 RSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVY 1134

  Fly  1156 IHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLE 1220
            |||||||||||||||:|||||.||||||||||||||:|||||||:||:.||||||||.||.||||
Human  1135 IHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLE 1199

  Fly  1221 PLYNKYEEPNAWRISRVRRRR 1241
            ||||:|||||||||||..|||
Human  1200 PLYNRYEEPNAWRISRAFRRR 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668	48/66 (73%)
		S1_DHX8_helicase	285..363	CDD:240189	53/77 (69%)
		HrpA	578..>1203	CDD:441249	541/624 (87%)
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668	48/66 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266		51/141 (36%)
		S1_DHX8_helicase	265..343	CDD:240189	53/77 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372		15/38 (39%)
		HrpA	556..>1187	CDD:441249	544/630 (86%)
		DEAH box	685..688		2/2 (100%)