Protein Alignment pea and mle

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: XP_316626.5
• Gene: mle / 1277182
• VectorBaseID: AGAMI1_002111
• Length: 1320
• Species: Anopheles gambiae
• Alignment Length: 918
• Identity: 233/918 - (25%)
• Similarity: 409/918 - (44%)
• Gaps: 166/918 - (18%)

  Fly   395 LNLQGNGME-GDEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDE--A 456
            ||....|.| |...:|..:...:|.     |:|:...||::..        ||.|......|  |
Mosquito   212 LNRTITGRESGSNKQSASKSCALSL-----IRQLYHLGVIEAF--------TGSLKSATASEQLA 263

  Fly   457 DIEIEIVEEEPPFLSGHGRALHD------LSPVRIVKNPDGSLAQAAMMQSALSKERREQKMLQR 515
            ...::|..:       ..:.:|:      :.||::  ||            |....:....:|..
Mosquito   264 AYPVKISNQ-------LAQRVHETLLEMGVQPVKV--NP------------AAENPKESVSLLHP 307

  Fly   516 EQEIEAMPTSLNK-------NWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGK 573
            ..::...|.|.|.       :|..|:| :.:..|..|:.....|...:.:..:.::  .:||...
Mosquito   308 SDDVHFKPQSTNLHQPASVISWSPPVP-NWNAWLGCNIDEGYLATASLDQLSEDLL--NESSSRL 369

  Fly   574 KTDLTL---VEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGE----CGFTAR 631
            |.||.|   :..|:.|||..:|..:::|:.::.::::.|.||.||||||.|::.|    .|..|.
Mosquito   370 KDDLELQKSMRTREKLPISAMRKPIMEAINEHPVVLIRGNTGCGKTTQIAQFILEDYINSGQGAY 434

  Fly   632 GKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFED-CTSPETIIKYMTDGMLLRECLMEA 695
            ..:..|||||::|:||::|:|.|....||..|||::||:. ...|...|.:.|.|:|||:  :|.
Mosquito   435 CNVCVTQPRRISAISVSERIANERCENLGVTVGYSVRFDSVLPRPYGSILFCTIGVLLRK--LEG 497

  Fly   696 ELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPG 760
            .|:..|.:::||.|||.:::|.:..:|:..|...|:|::|:.|||:|...||:||...|:..:||
Mosquito   498 GLRGVSHVIVDEIHERDVNSDFILVVLRDMVHTYPDLRVILMSATIDTSLFSRYFGDCPVLEVPG 562

  Fly   761 RTFPVEVLYTKE----------------------------------------PE----TDYLDAS 781
            |.||||.|:.::                                        ||    .:.:|.|
Mosquito   563 RAFPVEQLFLEDCIELLKFRPSPPEGGAGRRKRGKDGEDDGGDGGGECDADMPECGNLNEVIDES 627

  Fly   782 ---------------------LITVMQIHLREP--PGDILLFLTGQEEIDTACEILYERMKSLGP 823
                                 |||.:..::.:.  ||.:|:||.|       ..:::..|:.|.|
Mosquito   628 KYSPQTKQAMAMMIEADTPFELITALVDYVDQQGRPGAVLVFLAG-------WNMIFALMRQLQP 685

  Fly   824 DVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNS 888
            . ..|::||::|.||.|.|.::|:.. ...|||::||||||||:|||.:.||:|....:.|::.|
Mosquito   686 R-QNLVVLPLHSQLPREDQRKVFNHY-GQRRKVILATNIAETSITIDDVVYVIDTCKARMKLFTS 748

  Fly   889 KTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQL 953
            ...|.:......::...:||.|||||..||..:.| ..||...::.....||:.||.|....|.:
Mosquito   749 HNNMTNYATVWAARTNLEQRKGRAGRVSPGMCFTL-CSRARFAKLEENLTPEMFRTPLHELALSI 812

  Fly   954 KTMGINDLLHF--DFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIM 1016
            |.:.:..:..|  ..::.||:::::.|...|..:..||:|..||..||.:|..|:||.|.||:::
Mosquito   813 KLLRLGAIGKFLSKAIEPPPLDAVIEAEVLLKEMRCLDEEEQLTPFGRILARLPIEPRLGKMMVL 877

  Fly  1017 SVALQCSDEILTIVSML-SVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSWKNNK--- 1077
            |......|.:.|:.:.. :...||.....::.|.:.:||...|...|::.:|..:..|...:
Mosquito   878 STLFGLCDTLTTMAAYSGTFSEVFLLELGQRRLMNHQKALSGQTCSDYVAMLTAFEMWSKKRAIG 942

  Fly  1078 --FSNAWCYENFVQIRTLKRSQDVRKQLL----------GIMDRHKLDVVSAGKNSVRIQKAICS 1130
              ....:|....:|:.||:...:.:|||:          ..|...:.|..:...:.......:|.
Mosquito   943 EEAEMRFCDWKGLQMPTLRSIAEAKKQLIENLCLAGFPQDTMMPLRFDSENPDSDLEMAMALLCI 1007

  Fly  1131 GFFRNAAKKDPQEGYRTL-VDSQVVYIHPSSALFNRQP-----EWVIYHELVQTTKEYMREVTTI 1189
            |.:.|....  :|..|.| .:|:...:|.:|...:..|     .:.::.|.::|.....::::.:
Mosquito  1008 GLYPNVCYH--KEKRRVLTTESRAALMHKTSVNCSNAPTTFPYPFFVFGEKIRTRAVSCKQMSMV 1070

  Fly  1190 DPKWLVEF 1197
            .|..|:.|
Mosquito  1071 TPIHLLLF 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	195/719 (27%)
mle	XP_316626.5	None