Protein Alignment pea and TDRD9

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 925
• Identity: 231/925 - (24%)
• Similarity: 408/925 - (44%)
• Gaps: 221/925 - (23%)

  Fly   460 IEIVEEEPPFLSGHGR---ALHDLSPVRIVKNPDGSLAQAAMMQSALSKERR--EQKMLQREQEI 519
            :|::...|.|.:|..|   ...|::|      ..|..|||..:..|.::...  |:.:.||..|:
Human    23 VELLGAPPAFPAGAAREEVQRQDVAP------GAGPAAQAPALAQAPARPAAAFERSLSQRSSEV 81

  Fly   520 EAMPTSLNK-NWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVE-- 581
            |    .:|| ..::....|..||:         .|...|        |.:.|..|.:.:|.:.
Human    82 E----YINKYRQLEAQELDVCRSV---------QPTSGP--------GPRPSLAKLSSVTCIPGT 125

  Fly   582 --QRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARG---KIGCTQPRR 641
              :...|||.:.:::::..:..|.::|:.|.|||||:||:.||:.: .:..|.   .|..||||:
Human   126 TYKYPDLPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILD-HYVQRSAYCSIVVTQPRK 189

  Fly   642 VAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLD 706
            :.|.|:|:.:::|....||..|||.:..|...:.:|.:.|||.|:||::.:....|..::.|::|
Human   190 IGASSIARWISKERAWTLGGVVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIIID 254

  Fly   707 EAHERTIHTDVLFGLLKTAVQKRPE-LKLIVTSATLDAVKFSQYFF--------KAPIFTIPGRT 762
            |.||||...|.|..:::..::.... :|:::.|||:...:|:.||.        .|.||.:.|:.
Human   255 EVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPAYIFEVEGKP 319

  Fly   763 FPVEVLYTKEPETDYLDASLITVMQIHLREPP--------------------------------- 794
            ..||..|..:.|  ::..|.::.   ||.|.|
Human   320 HSVEEYYLNDLE--HIHHSKLSP---HLLEEPVITKDIYEVAVSLIQMFDDLDMKESGNKAWSGA 379

  Fly   795 ------GDILLFLTGQEEIDTACEIL----YERMKSLGPDVPELIILPVYSALPSEMQTRIF-DP 848
                  ..:|:||.|..||:...|:|    ::|::          :.|::|::..|.|..:| .|
Human   380 QFVLERSSVLVFLPGLGEINYMHELLTSLVHKRLQ----------VYPLHSSVALEEQNNVFLSP 434

  Fly   849 APAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAG 913
            .| |.||::::|||||:|:|:..:.||:|....:..|.:..|...||.::..|:.:..||.||||
Human   435 VP-GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGRAG 498

  Fly   914 RTGPGKTYRLYTERAYRDEMLPT-PVPEIQRTNLATTVLQLKTMGIND---LLHFDFMDAPP--- 971
            |...|..||| ..:.:.|..:|. .|||:.|..|.:|:|::|.:.:.:   ||....  :||
Human   499 RVSRGYCYRL-VHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATAL--SPPGLS 560

  Fly   972 -VESLVMALEQLHSLSA---LDDE----GLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILT 1028
             :|..::.|:::.:|:.   .:||    |.||.|||.:|:.|:...|.|::::.....|.||.|.
Human   561 DIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGHVFGCLDECLI 625

  Fly  1029 IVSMLSVQNVFYRPKDKQALADQKKAKFN-QAEGDHLTLLAVYNSWKNNKFSNA---------WC 1083
            |.:.||::|.|..|..:.....:.|..|: .::.|.:.|:..:.:||..:.:..         |.
Human   626 IAAALSLKNFFAMPFRQHLDGYRNKVNFSGSSKSDCIALVEAFKTWKACRQTGELRYPKDELNWG 690

  Fly  1084 YENFVQIRTLKRSQDVRKQL--------------LGIMD-------RHKLDVVSAGKNSVRIQKA 1127
            ..|::||:.::...::.::|              ..:||       |..|.||.||        |
Human   691 RLNYIQIKRIREVAELYEELKTRISQFNMHVDSRRPVMDQEYIYKQRFILQVVLAG--------A 747

  Fly  1128 ICSGFF-----------RNAAKKDPQEGYRTLVDSQVVYIH-PSSALFNRQPEWVIYHELVQTTK 1180
            ....:|           |..|.|||:        :.||..| |        |...:|::.:|:..
Human   748 FYPNYFTFGQPDEEMAVRELAGKDPK--------TTVVLKHIP--------PYGFLYYKQLQSLF 796

  Fly  1181 EYMREVTTIDPKWLVEFAPSFFRFS-DPT-------------KLSKFKKNQRL-----EPLYNKY 1226
            ....:|.:|    :.:.|.:|..|| :||             |:|:.|.:..|     |.:..|.
Human   797 RQCGQVKSI----VFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEGKV 857

  Fly  1227 EEPNAWRISRVRRRR 1241
            :..|   :|::|..|
Human   858 QGMN---VSKLRNTR 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189
		HrpA	578..>1203	CDD:441249	190/742 (26%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62		7/31 (23%)
		HrpA	130..>716	CDD:441249	163/605 (27%)
		DEXHc_TDRD9	132..315	CDD:350746	58/183 (32%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Tudor_TDRD9	905..1005	CDD:410502