DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and Dhx57

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	1202	Identity:	299/1202 - (24%)
Similarity:	503/1202 - (41%)	Gaps:	328/1202 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 CFVQLFGLRKRW-EGLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSG 363
            ||.:.||.|... |..|::|          :.|.|.:.|...:.:.||.|:|....::......|
Mouse   221 CFSETFGERMALSEAAVYVS----------LNECVEQRQEETLALKSICGEKFIERIQNRVWTIG 275

  Fly   364 KDLNPL------SHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRV---TRISSP 419
            .:|:.|      |...|..:::||.:|:      |....|:||...|.:.:.:..|   ..|...
Mouse   276 LELDYLTNKFCKSKQKESSKNVRDTSPE------TCKFYLKGNCKFGSKCKFKHEVPPHQMIGRA 334

  Fly   420 ERWEIKQMISSGVLDRSEMPDFDEETGL-----------------------LP------------ 449
            ||     .::...||..:...|..|..:                       ||
Mouse   335 ER-----NVNDPHLDADDDTTFMYELQIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLY 394

  Fly   450 -------KDEDDEADIEIEIVEEEPPF--LSGHGRALHDLSPVRIVKNP-DGSLAQAA------- 497
                   |..:......|.::|||...  |..|.:..:.:.||.:...| :..:::.|
Mouse   395 GKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPVNVPPVPSETRISKPAYRKPVVP 459

  Fly   498 ----MMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPE 558
                :....|..||..:  |:.:.:.:..|.|:       :.|:||   ..|::..:....:.|
Mouse   460 SNTFLSNQMLEGERLSE--LEEDADEDEGPASI-------IVENES---YVNLKKRSYKRYDRP- 511

  Fly   559 WKKHVIGGKKSSFGKKTDL--------------TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIG 609
                    .||.|.:.:.:              .::::||.||.::.|:.::|.::.:|::::.|
Mouse   512 --------AKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISG 568

  Fly   610 ETGSGKTTQITQYLGECGFTAR----GKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFE 670
            .||.||||||.|::.:......    ..|.||||||::|:|||:|||:|...|:|..|||.||.|
Mouse   569 MTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLE 633

  Fly   671 DCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLI 735
            ...|..|.:.|.|.|:|||....:|.|:..:.|::||.||||..:|.|..:||..|.:|..|::|
Mouse   634 SVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVI 698

  Fly   736 VTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLIT--VMQ----------- 787
            :.||||||..||:||...|:.|||||.|||:..:.:       ||..:|  |:|
Mouse   699 LMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLE-------DALAVTRYVLQDGSPYMRSMKQ 756

  Fly   788 -------------------------IHLRE----------------------------------- 792
                                     :||::
Mouse   757 IAKEKLKARHNRTAQEEVEEDLRLSLHLQDEEESVKDTIPDQQLDFKQLLIRYKGVSKSVIKTMS 821

  Fly   793 --------------------------PPGDILLFLTGQEEIDTACEILYERMKS----LGPDVPE 827
                                      |||.:|:||.|..||    ::|||:::|    .......
Mouse   822 VMDFEKVNLELIEALLEWIVDGKHAYPPGAVLVFLPGLAEI----KMLYEQLQSNSLFNNRRSHR 882

  Fly   828 LIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGM 892
            .:|.|::|:|.||.|..:|...|.|..|::|:|||||||:|||.:.||:|.|.:|:|.|::..||
Mouse   883 CVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGM 947

  Fly   893 DSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMG 957
            :||..|.:|||.|.||.|||||...|..:.|:|...|..::|...:|||||..|....|::|.:.
Mouse   948 ESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILE 1012

  Fly   958 INDLLHFD-----FMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMS 1017
            :....:..     .::.|.::||..:..:|..|.||..:..||.||..:|..|::..:.|::::.
Mouse  1013 MFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLG 1077

  Fly  1018 VALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSW-----KNNK 1077
            ...:|.|..|||.:.|:.::.|..|.||:..|:|||.:|..|..|:|.||..|..|     ::.:
Mouse  1078 SIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGWQLSTKESAR 1142

  Fly  1078 FSNAWCYENFVQIRTLKRSQDVRKQLL--------------------------GIMDRHKLDVVS 1116
            .|..:|.:||:..|||:....:::|..                          |::|....:..:
Mouse  1143 ASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANT 1207

  Fly  1117 AGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQV-------------------VYIHPSSAL 1162
            ..:|...|...:|:..:.|..:....||......|.|                   |:|||||..
Mouse  1208 NAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVN 1272

  Fly  1163 F---NRQPEWVIYHELVQTTKEYMRE--------------------------VTTIDPKWLVEFA 1198
            :   :....:::|||.::|::.::|:                          |.::|..| :.|.
Mouse  1273 YQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGW-IRFV 1336

  Fly  1199 PSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPN 1230
            .:..:.::..|..:.:.:|.|:   :|.:.|:
Mouse  1337 AASHQVAELVKELRCELDQLLQ---DKIKNPS 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	15/63 (24%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	234/852 (27%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD	246..419	CDD:368608	32/183 (17%)
		HrpA	501..1298	CDD:224557	230/816 (28%)
		DEVH box	669..672		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810