Protein Alignment pea and Dhx57

DIOPT Version :10

• Sequence 1: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Sequence 2: NP_001157231.1
• Gene: Dhx57 / 106794
• MGIID: 2147067
• Length: 1388
• Species: Mus musculus
• Alignment Length: 1202
• Identity: 299/1202 - (24%)
• Similarity: 503/1202 - (41%)
• Gaps: 328/1202 - (27%)

  Fly   300 CFVQLFGLRKRW-EGLVHISQLRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSG 363
            ||.:.||.|... |..|::|          :.|.|.:.|...:.:.||.|:|....::......|
Mouse   221 CFSETFGERMALSEAAVYVS----------LNECVEQRQEETLALKSICGEKFIERIQNRVWTIG 275

  Fly   364 KDLNPL------SHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGMEGDEHESRKRV---TRISSP 419
            .:|:.|      |...|..:::||.:|:      |....|:||...|.:.:.:..|   ..|...
Mouse   276 LELDYLTNKFCKSKQKESSKNVRDTSPE------TCKFYLKGNCKFGSKCKFKHEVPPHQMIGRA 334

  Fly   420 ERWEIKQMISSGVLDRSEMPDFDEETGL-----------------------LP------------ 449
            ||     .::...||..:...|..|..:                       ||
Mouse   335 ER-----NVNDPHLDADDDTTFMYELQIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLY 394

  Fly   450 -------KDEDDEADIEIEIVEEEPPF--LSGHGRALHDLSPVRIVKNP-DGSLAQAA------- 497
                   |..:......|.::|||...  |..|.:..:.:.||.:...| :..:::.|
Mouse   395 GKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPVNVPPVPSETRISKPAYRKPVVP 459

  Fly   498 ----MMQSALSKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPE 558
                :....|..||..:  |:.:.:.:..|.|:       :.|:||   ..|::..:....:.|
Mouse   460 SNTFLSNQMLEGERLSE--LEEDADEDEGPASI-------IVENES---YVNLKKRSYKRYDRP- 511

  Fly   559 WKKHVIGGKKSSFGKKTDL--------------TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIG 609
                    .||.|.:.:.:              .::::||.||.::.|:.::|.::.:|::::.|
Mouse   512 --------AKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISG 568

  Fly   610 ETGSGKTTQITQYLGECGFTAR----GKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFE 670
            .||.||||||.|::.:......    ..|.||||||::|:|||:|||:|...|:|..|||.||.|
Mouse   569 MTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLE 633

  Fly   671 DCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLI 735
            ...|..|.:.|.|.|:|||....:|.|:..:.|::||.||||..:|.|..:||..|.:|..|::|
Mouse   634 SVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVI 698

  Fly   736 VTSATLDAVKFSQYFFKAPIFTIPGRTFPVEVLYTKEPETDYLDASLIT--VMQ----------- 787
            :.||||||..||:||...|:.|||||.|||:..:.:       ||..:|  |:|
Mouse   699 LMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLE-------DALAVTRYVLQDGSPYMRSMKQ 756

  Fly   788 -------------------------IHLRE----------------------------------- 792
                                     :||::
Mouse   757 IAKEKLKARHNRTAQEEVEEDLRLSLHLQDEEESVKDTIPDQQLDFKQLLIRYKGVSKSVIKTMS 821

  Fly   793 --------------------------PPGDILLFLTGQEEIDTACEILYERMKS----LGPDVPE 827
                                      |||.:|:||.|..||    ::|||:::|    .......
Mouse   822 VMDFEKVNLELIEALLEWIVDGKHAYPPGAVLVFLPGLAEI----KMLYEQLQSNSLFNNRRSHR 882

  Fly   828 LIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGM 892
            .:|.|::|:|.||.|..:|...|.|..|::|:|||||||:|||.:.||:|.|.:|:|.|::..||
Mouse   883 CVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGM 947

  Fly   893 DSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMG 957
            :||..|.:|||.|.||.|||||...|..:.|:|...|..::|...:|||||..|....|::|.:.
Mouse   948 ESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILE 1012

  Fly   958 INDLLHFD-----FMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFPLEPNLSKMLIMS 1017
            :....:..     .::.|.::||..:..:|..|.||..:..||.||..:|..|::..:.|::::.
Mouse  1013 MFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLG 1077

  Fly  1018 VALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVYNSW-----KNNK 1077
            ...:|.|..|||.:.|:.::.|..|.||:..|:|||.:|..|..|:|.||..|..|     ::.:
Mouse  1078 SIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGWQLSTKESAR 1142

  Fly  1078 FSNAWCYENFVQIRTLKRSQDVRKQLL--------------------------GIMDRHKLDVVS 1116
            .|..:|.:||:..|||:....:::|..                          |::|....:..:
Mouse  1143 ASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANT 1207

  Fly  1117 AGKNSVRIQKAICSGFFRNAAKKDPQEGYRTLVDSQV-------------------VYIHPSSAL 1162
            ..:|...|...:|:..:.|..:....||......|.|                   |:|||||..
Mouse  1208 NAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVN 1272

  Fly  1163 F---NRQPEWVIYHELVQTTKEYMRE--------------------------VTTIDPKWLVEFA 1198
            :   :....:::|||.::|::.::|:                          |.::|..| :.|.
Mouse  1273 YQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGW-IRFV 1336

  Fly  1199 PSFFRFSDPTKLSKFKKNQRLEPLYNKYEEPN 1230
            .:..:.::..|..:.:.:|.|:   :|.:.|:
Mouse  1337 AASHQVAELVKELRCELDQLLQ---DKIKNPS 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189	15/63 (24%)
		HrpA	578..>1203	CDD:441249	231/815 (28%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	243..425	CDD:467661	35/192 (18%)
		zf_CCCH_4	305..323	CDD:465719	4/17 (24%)
		HrpA	545..>1172	CDD:441249	204/637 (32%)
		DEVH box	669..672		2/2 (100%)
		OB_NTP_bind	1215..1312	CDD:400182	18/96 (19%)