DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and Dhx29

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_002729053.2	Gene:	Dhx29 / 100362324	RGDID:	2318361	Length:	1366	Species:	Rattus norvegicus

Alignment Length:	1450	Identity:	325/1450 - (22%)
Similarity:	562/1450 - (38%)	Gaps:	439/1450 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 INDKDLAEFIIDLENKNRTYDTFR---------KALLD----------NGAEFPDSLVQNLQR-- 69
            ||:| |.:.||.:.|:::..:..|         |.|.|          ...:..|::...|..
  Rat    88 INNK-LEQRIIGVINEHKKQNNDRGVISGRLSAKKLQDLYMALQAFSFKTKDIEDAMTNTLLHGG 151

  Fly    70 ---------IINLMRPSRPGGASQEKTVGDKKEDKKSQLLKMFPGLALPNDTYSKKEESDDDEKV 125
                     .:||...:.|.|.|||......|...|.|.:::...|:.|..|.:|::|  :|.|:
  Rat   152 DLHSALDWLCLNLSDDALPEGFSQEFEEQQPKSRPKFQSVQIQATLSPPLQTKTKRQE--EDPKI 214

  Fly   126 KAKPEKHSETHKKTDMSDVDAAMMELEALAPGEGATLVRPHKEVSSRDRHKRRSRDRDTKRRSRS 190
            |.|.|:.|                                 .||:.::...|.:..::.:.:|..
  Rat   215 KPKKEEKS---------------------------------MEVNMKEWILRYAEQQNEEEKSEG 246

  Fly   191 REDRHSDRRRSRSRDKERRRRSRSRDNRRRSRSREDRDR-DRDRRHKSSSSRDHHERRRRSRSRS 254
                                          |:..||.|: |.::|:.:.::|....:.:.:..:.
  Rat   247 ------------------------------SKGSEDEDKFDPNQRYLNLAARLLDAKEQAAAFKV 281

  Fly   255 TERRDRRDRSRDCSEKMPPPSAAMTDDPEAGKIYSGKIANIVPFGCFVQLFGLRKRWEGLVHISQ 319
            .:.:..:..:::...|.......:.|.|                     :|
  Rat   282 EKNKQGQKEAQEKIRKFQREMETLEDHP---------------------IF-------------- 311

  Fly   320 LRAEGRVTDVTEVVTRNQTVKVKVMSITGQKVSLSMKEVDQDSGKDLN----PLSHAPEDDESLR 380
                            |..:|:.......:|..|:   .|.:|..:.|    |.:...|:
  Rat   312 ----------------NPAIKISHQQNERKKAPLA---TDGESALNFNLFEKPAAATEEE----- 352

  Fly   381 DRNPDGPFSSSTSMLNLQGNGMEGDEHESRK-----RVTRISSPERWEIKQMISSGVLDRSEMPD 440
                               .|.:.:.|:.|.     |.....||:::.|..:..:  |.:|..|.
  Rat   353 -------------------KGKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKN--LPKSPNPS 396

  Fly   441 FDEETGLLP------------KDEDDEADIEIEIVEEEPPFLSGH------------GRALHDLS 481
            |::    :|            |.|||...:...|:.|: ...:.|            |:::|.|.
  Rat   397 FEK----VPVGRYWKCRVRVVKSEDDVLVVCPTILTED-GMQAQHLGATLALYRLVKGQSVHQLL 456

  Fly   482 PV--------------------RIVKNPDGSLAQAAMMQSALSKERREQKMLQREQEIEAMPTSL 526
            |.                    ::..|....|..|.:    |||.:::|::.|:.|..|....:.
  Rat   457 PPTYRDVWVEWSDEEKKKEELNKMETNKPRDLFIAKL----LSKLKQQQQLQQQRQHPENKTETA 517

  Fly   527 ---NKNWIDPLPEDESRSLAANMRGMAAAPP---------EVPEWKKHVIGGKKSSFGKKTDLTL 579
               .::|.:.:.:::..:|:....|.....|         ..|::::                 |
  Rat   518 EDPEESWENLVSDEDLSALSLEPTGAEDLEPVRNLFRRLQSTPKYQR-----------------L 565

  Fly   580 VEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQY------LGECGFTARGKIGCTQ 638
            :::||.||::|.|..:::.:..:::::|.|||||||:||:..:      |.:|| ..:..|.|||
  Rat   566 LKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCG-ARKCNIVCTQ 629

  Fly   639 PRRVAAMSVAKRVAEEYGCRLG-----QEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELK 698
            |||::|:|:|.||.||.||..|     ...||.||.|...|..|.:.|.|.|:|||:...:..|.
  Rat   630 PRRISAVSLATRVCEELGCEGGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLA 694

  Fly   699 SYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFKAPIFTIPGRTF 763
            ..|.:::||.|||::.:|.|..:||..:|||.:|.||:.|||:|:.|||.||...||..|.||::
  Rat   695 DVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSY 759

  Fly   764 PVEVLYTKE---------------------------------------------------PE--- 774
            ||||.:.::                                                   ||
  Rat   760 PVEVFHLEDIVEETGFILEKDSEYCQKFLEEEEEITINVTSKAGGIKKYQECIPVQSGASPELSP 824

  Fly   775 --------TDY---------LDASLITVMQIHLREPP------GDILLFLTGQEEIDTACEIL-- 814
                    |.|         ::..||..:.::|.:.|      |.:|:||.|...|....::|
  Rat   825 FYQKYSSRTQYAVLYMNPHKINLDLILELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSN 889

  Fly   815 -----YERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFY 874
                 .||.:          ::.::|.|.::.|...|...|.|.||:|:|||||||.:||..:.:
  Rat   890 DRRFYSERYQ----------LIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVVF 944

  Fly   875 VVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVP 939
            |:|.|..|:..|:..:.|.|||.|.:|:|:|.||.|||||...|..:||||...: :..|...||
  Rat   945 VIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERF-EGFLEYSVP 1008

  Fly   940 EIQRTNLATTVLQLKTMGINDLLHF--DFMDAPPVESLVMALEQLHSLSALD-DEGLLTRLGRRM 1001
            ||.|..|....|.:....:.....|  ..:|.|..:.:..|:..|..:.|.: .|..||.||:.:
  Rat  1009 EILRVPLEELCLHIMKCDLGSPEDFLSKALDPPQPQVISNAMNLLRKIGACEPSEPKLTPLGQHL 1073

  Fly  1002 AEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTL 1066
            |..|:...:.||||......|.:.:.|:.::::.::.|..|..::..||..|:....|:.||||:
  Rat  1074 AALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLAKSSLAVADSDHLTI 1138

  Fly  1067 LAVYNSWKNNKFSN------AWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNS---- 1121
            ...|..||..:...      ::|..||:...:|...:||:::|:.:       |.:||.:|
  Rat  1139 YNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLTLEDVKQELMKL-------VRAAGFSSSTSW 1196

  Fly  1122 -------------VRIQKAI-CSGFFRNAAK------KDPQEGYRTLVDSQ--VVYIHPSSALFN 1164
                         :.:.||: .:|.:.:..|      .|..|....:|::.  ...:||||.  |
  Rat  1197 EGKKGPQALSFQDIALLKAVLAAGLYDSVGKIMCTKSVDVTEKLACMVETAQGKAQVHPSSV--N 1259

  Fly  1165 RQPE---WVIYHELVQTTKEYMREVTTIDPKWLVEF--------------APSFFRFSDPTKLSK 1212
            |..:   |::|.|.|:..:.|:||.|.|.|..::.|              ...:..|..|.|::.
  Rat  1260 RDLQTYGWLLYQEKVRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSVDGWIYFQAPVKIAV 1324

  Fly  1213 FKKNQRL---EPLYNKYEEP 1229
            ..|..|:   ..|..|.|.|
  Rat  1325 IFKQLRVLIDSVLRKKLENP 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	6/77 (8%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	225/797 (28%)
Dhx29	XP_002729053.2	HrpA	531..1314	CDD:224557	224/820 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810