DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and dhx15

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	NP_001135571.1	Gene:	dhx15 / 100216120	XenbaseID:	XB-GENE-1008945	Length:	761	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	361/746 - (48%)
Similarity:	491/746 - (65%)	Gaps:	47/746 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 SKERREQKMLQREQEIEAMPTSLNKNWIDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKK 568
            ||:|...:...||::.:.          |......|.|......||   ||..|       ....
Frog    34 SKDRDRDRDRDRERDRDK----------DKDSRGSSNSTYITASGM---PPLKP-------AAVA 78

  Fly   569 SSFGKKTDL-------TLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQ----Y 622
            ......|:|       .::::|..||:::.::...:.:..||..:::|||||||||||.|    |
Frog    79 QGINPFTNLPHTPRYYDILKKRLLLPVWEYKERFTEILMKNQSFVLVGETGSGKTTQIPQWCVDY 143

  Fly   623 LGECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSPETIIKYMTDGML 687
            :.......|| :.|||||||||||||:|||:|....|||||||:||||||:|.:||:||||||||
Frog   144 MRLLPGPKRG-VACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGML 207

  Fly   688 LRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELKLIVTSATLDAVKFSQYFFK 752
            |||.:.:..|:.|.|::||||||||:.||:|.|:||..|::|.:||:||.||||||.||..||..
Frog   208 LREAMNDPLLERYGVVILDEAHERTLATDILMGVLKEVVRQRNDLKVIVMSATLDAGKFQVYFDS 272

  Fly   753 APIFTIPGRTFPVEVLYTKEPETDYLDASLITVMQIHL-REPPGDILLFLTGQEEIDTACEILYE 816
            .|:.||||||.|||:.||.|||.|||:|::.||:|||: .|..||:|||||||||||.||:.:..
Frog   273 CPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKR 337

  Fly   817 RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP------AGSRKVVIATNIAETSLTIDGIFYV 875
            .:..|||||.::.|:|:||.||.:.|.|||:|.|      |..||||::||||||||||||:.:|
Frog   338 EIDDLGPDVGDIKIIPLYSTLPPQQQQRIFEPPPPKKPSGAIGRKVVVSTNIAETSLTIDGVVFV 402

  Fly   876 VDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPE 940
            :||||.||||||.:..::||:||.||:|:|:|||||||||.|||.:|||||:||:.||.....||
Frog   403 IDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPE 467

  Fly   941 IQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDDEGLLTRLGRRMAEFP 1005
            |.|:||.:.|||||.:||:||:||||||.|..|:|:.|||.|:.|:||:|:|.||.||..|||||
Frog   468 ILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFP 532

  Fly  1006 LEPNLSKMLIMSVALQCSDEILTIVSMLSVQNVFYRPKDKQALADQKKAKFNQAEGDHLTLLAVY 1070
            |:|.|:||:|.|....||:|||:|.:||||...|.||.:.:..||:.|.:|...:|||||||.||
Frog   533 LDPQLAKMVIASCDYNCSNEILSITAMLSVPQCFIRPTEVKKAADEAKMRFAHIDGDHLTLLNVY 597

  Fly  1071 NSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNS----VRIQKAICSG 1131
            :::|.|..|:.|||:||:..|:|..:.:||:||..||||..|...|....|    :.|:||:.:|
Frog   598 HAFKQNHESSQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTG 662

  Fly  1132 FFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVE 1196
            :|...|..:....|.|:.|:|||.:|||:.| :.:||||:|:|.|.|||.|:|..|.|.|:|||:
Frog   663 YFMQVAHLERTGHYLTVKDNQVVQLHPSTVL-DHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVK 726

  Fly  1197 FAPSFFRFSDPTKLSKFKKNQRLEPLYNKYE 1227
            .|..::   |.:...:.:..::||.:..|.:
Frog   727 IAAQYY---DMSNFPQCEAKRQLERIVAKLQ 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189
pea	NP_610928.1	HrpA	573..1221	CDD:224557	346/669 (52%)
dhx15	NP_001135571.1	Motor_domain	81..>133	CDD:277568	13/51 (25%)
		DEXDc	97..288	CDD:214692	107/191 (56%)
		DEXDc	120..261	CDD:238005	85/141 (60%)
		HELICc	348..441	CDD:197757	54/92 (59%)
		HA2	511..594	CDD:214852	43/82 (52%)
		OB_NTP_bind	628..731	CDD:285018	44/103 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010