DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pea and dhx37

DIOPT Version :9

Sequence 1:	NP_610928.1	Gene:	pea / 36561	FlyBaseID:	FBgn0086895	Length:	1242	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	1107	Identity:	317/1107 - (28%)
Similarity:	487/1107 - (43%)	Gaps:	251/1107 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LRKR--WEGLVHIS--QLRAEGRVTDV-----------------TEVVTRNQTVKVKVMSITGQK 350
            |||:  |:|....:  |..|..|.|:|                 ..|:...:|.|.||.....:|
Zfish     4 LRKKHNWKGRQQSTSVQTAAADRQTNVQVEIQDGAVLKGVDDCNALVLPATKTKKQKVERPVTKK 68

  Fly   351 VSLSMKE-------VDQDSGKD-----LNPLSHAPEDDESLRDRNPDGPFSSSTSMLNLQGNGME 403
            .:|:.|:       ::|...|.     |:.|:.....:..|:.........:...:.:::.:..|
Zfish    69 KALTKKQRKNLEKVLEQKDKKAHRAEVLSKLAEVQLPEAELKLLYTTAKLGTGGKLYHIKESVNE 133

  Fly   404 G-DEHESRKRVTRISSPERWEIKQMISSGVLDRSEMPDFDEETGLLPKDEDDEADIEIEIVEEEP 467
            | |...|..:::.:|...|...::.......:.|||.:..|:..  ..:|.|.::.|.|.:.||
Zfish   134 GQDGGSSSVKISSLSGANRKRRREADEEEEENESEMSESSEDDD--DSEESDSSEEEKEKISEE- 195

  Fly   468 PFLSGHGRALHDLSPVRIVKNPDGSLAQAAMMQSALSKE--RREQKMLQREQEIEAMPTSLNKNW 530
                               |:.:....|..:.:....||  .:|:|..:...:.:..|.....
Zfish   196 -------------------KHTEEQQQQQVLKEETKPKEADMKEEKKAETWTKEDCKPAVFIP-- 239

  Fly   531 IDPLPEDESRSLAANMRGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDL 595
            ::.|||                                          :.|.|..||:......:
Zfish   240 VERLPE------------------------------------------IQEARLRLPVLAEEQII 262

  Fly   596 IKAVTDNQILIVIGETGSGKTTQITQYLGECGFTARGK-IGCTQPRRVAAMSVAKRVAEEYGCRL 659
            ::||.|::.:::.||||||||||:.|:|.|.||.:.|. ||.|:||||||:|::.|||.|.....
Zfish   263 MEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVTEPRRVAAISMSHRVATEMNLSS 327

  Fly   660 GQEVGYTIRFEDCTSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKT 724
            | .|.|.||:|...:..|.||.||||:||:|...:..|:.||||::||||||:::||:|.|||..
Zfish   328 G-VVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIIIDEAHERSVYTDILIGLLSR 391

  Fly   725 AVQKRPE----LKLIVTSATLDAVKFSQ----YFFKAPIFTIPGRTFPVEVLYTKE-PETDYLDA 780
            .|..|.:    :|||:.||||....|::    :....|:..:..|.|.|.|.:.|. |..||...
Zfish   392 IVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSSPPPVIKVEARQFAVTVHFNKRTPMDDYTGE 456

  Fly   781 SLITVMQIHLREPPGDILLFLTGQEEIDTACEIL------------------------YERMK-- 819
            :...:.:||...|||.||:|||||.|:.:.|..|                        .:|.|
Zfish   457 TFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLRKAFPYKPNREHTDMMETEEDLKKSKRAKKK 521

  Fly   820 ----------------------------------------SLG------------PDVPELIILP 832
                                                    .||            |.:| |.:||
Zfish   522 NVSLPRINLDNYSALPVDEGDEDRQAGIDEDDGEGSDLELELGDHPDTDHEEKADPSIP-LYVLP 585

  Fly   833 VYSALPSEMQTRIFDPAPAGSRKVVIATNIAETSLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVV 897
            :||.|..|.|.::|.|.|||||..|:|||:|||||||.||.||||.|.||::.|:..||:.|..|
Zfish   586 LYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKV 650

  Fly   898 TPISQAAAKQRAGRAGRTGPGKTYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLL 962
            |.||||:|.|||||||||.||..||||:...:.|..|.:.. ||.|..:...|||:|.:.|..::
Zfish   651 TWISQASANQRAGRAGRTEPGHCYRLYSSAVFGDFSLFSEA-EITRRPVEDLVLQMKDLNIEKVV 714

  Fly   963 HFDFMDAPPVESLVMALEQLHSLSALDD---EGLLTR------------LGRRMAEFPLEPNLSK 1012
            :|.|...|..|:|:.|.|.|.||.||:.   .|.|:.            |||.||.||:.|..:|
Zfish   715 NFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEMEKARLSCPISPLGRAMAAFPVAPRYAK 779

  Fly  1013 MLIMSVALQCSDEILTIVSMLSVQNVFY---RP---KDKQALADQKKAKFNQAE----------- 1060
            ||.:.....|...|:||||.::|:.:|.   ||   :::......|||:..|..
Zfish   780 MLALGRQQGCMQYIITIVSAMTVREIFEDYDRPAGSEEENVKMSGKKARSVQMRRLWAGQGASLL 844

  Fly  1061 -GDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRSQDVRKQLLGIMDRHKLDVVSAGKNSVR- 1123
             ||.:.||....:.:....:..:|.||.::.:.:...:.:|.||...::....|......|.:.
Zfish   845 LGDLMVLLGAVGACEFAGLTPQFCEENGLRFKAMLEIRRLRGQLTNAVNAVCADADVYVDNKMAP 909

  Fly  1124 --------IQKAICSGFFRNAAKK-------DP--QEGYRTLVDSQVVYIHPSSALFNRQPEWVI 1171
                    :::.:.:|...:.|::       ||  :..|:|.:....|:|||||||....||:|:
Zfish   910 PTEAQVLCLRQIVLAGLGDHIARRVQAEELLDPKWRNAYKTPLLDDPVFIHPSSALHKTLPEFVV 974

  Fly  1172 YHELVQTTKEYMREVTTIDPKWLVEFAPSFFRFSDPTKLSKFKKNQRLEPLYNK---YEEPNAWR 1233
            |.|:::|||.|||.|..:...|:.:..|.:..||.|.:    ....|..||..:   :::...:|
Zfish   975 YQEIMETTKMYMRGVCAVQDDWIPKLLPQYCHFSAPEE----SPAPRFCPLIGRVKCHQQSTFFR 1035

  Fly  1234 IS 1235
            :|
Zfish  1036 VS 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pea	NP_610928.1	S1_DHX8_helicase	285..363	CDD:240189	19/83 (23%)
pea	NP_610928.1	HrpA	573..1221	CDD:224557	264/786 (34%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	269/853 (32%)
		DEXDc	272..412	CDD:238005	70/140 (50%)
		HELICc	583..667	CDD:197757	51/83 (61%)
		HA2	730..781	CDD:282288	18/50 (36%)
		HA2	761..>813	CDD:214852	20/51 (39%)
		OB_NTP_bind	<918..1004	CDD:285018	28/85 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820