DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcd1 and sumv-2

DIOPT Version :9

Sequence 1:	NP_001260963.1	Gene:	Rcd1 / 36560	FlyBaseID:	FBgn0033897	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001256043.1	Gene:	sumv-2 / 24104625	WormBaseID:	WBGene00018812	Length:	1145	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	162/739 - (21%)
Similarity:	269/739 - (36%)	Gaps:	195/739 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KSPALVVTSPCTPTES---------SSTISAPSESSFSEKMEHSYMRDTPVRSDVHNGLTPARNI 157
            ::||....||....|.         |....|..::|..|..::|...|..::..:...|..|:..
Worm   443 ETPAFDEESPIGGDEKRQQKARESISHLFDAEMDASIKEAKKYSVSFDKYIKPKITGALKHAKIK 507

  Fly   158 LVRHPPQC--PSCHTYPPQHEEL--------SEIQQAHV------------PPYDEV-------V 193
            |:....|.  |....|   ||.|        |.::...|            |...|:       :
Worm   508 LMSRKRQSAEPDDFYY---HELLVDQVSPSNSNVENVDVDVDIEETDDKVDPTEFEISEEGVIGI 569

  Fly   194 AKEAMNECARIAKYV----KNNNS----DEQDWVARVNKFNWTPMQEMVFEKVCSILDQDQLARL 250
            ..||::...:||..:    |::.|    ||....|..:..:.|...:...|.|.:.|..:.....
Worm   570 RDEAVDMAEQIALVIPRPTKHDGSPMSMDEIQMRAMEHVESRTKCLDGSLEIVLNQLGHEMAPPT 634

  Fly   251 ANDKRQHEPIHRRISSDKSASRFRKLLASVAWESRITQWIHALLMEHLSPSYMASYLEILQTLKT 315
            ...:.|....|...|::..|.:....:|:...|..|| |.|..::|:|....:||||.||:..|.
Worm   635 RGVEEQGCQWHTVTSANAQALKNLYTIANNCTEDAIT-WTHQFMIENLEVHMLASYLSILKYAKR 698

  Fly   316 KLPTLVDKMLFGRPLNNSQE-----------LLAPVMKKRWEP------NIMPKSRQLTHNAIMV 363
                 ::...||..::::.:           |.:.|.|:..||      |.:|..| :|....::
Worm   699 -----LNSSRFGYVISSTDQLDPEWTQVTSLLKSFVYKRHTEPGTEVLNNTIPYHR-MTDTVFLL 757

  Fly   364 VLPNMPTTGTVSD----------RMQKWYQALSTITQVVQISLPNTNNRIGNQN----------- 407
            |    |.|.|..|          |:.:|.|:                  ||:|:
Worm   758 V----PPTLTFGDHQRAPPRHHARIFRWLQS------------------IGHQDSEFISFDEDID 800

  Fly   408 -----LDHVAETIVSITRVKINELRTENPSRGIILVGFNAGAALALQVA-LSESVACVVCMGFAY 466
                 .:::::.||.....|:.:.....|:..::|||:.|...|..:.| |.|.::.::.:||..
Worm   801 ATCSVAEYLSDVIVERICDKVRQKNKYRPNCNVVLVGYGASTYLIHRAANLVEGISAIISIGFPV 865

  Fly   467 NTIRGPRGTPDDRMLDIKAPILFVIGQNSARTSQEEMEGLRERMQSESSLVVVGSADDALRVPKS 531
            .|..|.|||.||.:|....|.||::|....|.:.|.:..||..|.|.|.|||||.::|.:.||.|
Worm   866 MTSLGRRGTADDEILLTYCPTLFIVGAEGRRFNNEAITELRTSMISPSGLVVVGHSNDMILVPTS 930

  Fly   532 KRRIEGVTQSMVDYMVVEEIFEFVNRTLSNPPGPRMPTCLMHQQGYQRL-PKQSPHILADGNANK 595
            .....|::|::|..||:|:|.:|:|   ..|         :.||.:..| |.:..::.   :.:.
Worm   931 MLLRLGISQTVVFRMVLEKILDFLN---LEP---------VRQQEFADLVPIELNNVF---DLDS 980

  Fly   596 AVQQMRKRKMDGGLDDSMGQPSKTKFVPHNRVHKPKPPRLIDPFAVKRKVGRPRTRPLPNVGGSA 660
            |:  ::..|...||                            .||...........|.| ||.|.
Worm   981 AL--LKSDKALSGL----------------------------AFASSTHSASSSAAPSP-VGASG 1014

  Fly   661 RSVSQKGAPHPD----------------QPKLSGEEP--------NQSIEF--ILDDAQDYGDAQ 699
            |..:..||...|                .|.:||..|        ::.:.|  ::......||..
Worm  1015 RRATVTGAGSEDIAKRRKESIILSQQIAAPSISGPPPPAPSPRTEDRFLAFQNLVASTITTGDDM 1079

  Fly   700 TTAGGSASLPKVITPGVLGKQLPP 723
            .......:.|:||..|......||
Worm  1080 PRRASMGASPRVIERGDFRDHRPP 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcd1	NP_001260963.1	None
sumv-2	NP_001256043.1	BASP1	43..231	CDD:283191
sumv-2	NP_001256043.1	BRO1_Alix_like	<460..534	CDD:301330	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006481
OrthoInspector	1	1.000	-	-		oto20731
orthoMCL	1	0.900	-	-		OOG6_105996
Panther	1	1.100	-	-	LDO	PTHR13136
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3937
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860