DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mam and MAML1

DIOPT Version :9

Sequence 1:	NP_001286401.1	Gene:	mam / 36555	FlyBaseID:	FBgn0002643	Length:	1594	Species:	Drosophila melanogaster
Sequence 2:	NP_055572.1	Gene:	MAML1 / 9794	HGNCID:	13632	Length:	1016	Species:	Homo sapiens

Alignment Length:	1238	Identity:	278/1238 - (22%)
Similarity:	389/1238 - (31%)	Gaps:	444/1238 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 VPTAPGDTMPTKRMP----VVDRLRRRMENYRRRQTDCVPRYEQAFNTVCEQQNQETTVLQKRFL 176
            :||.|   |....:|    |::|||||:|..||..:.|..|||.......|.:.|.|..|.:|.:
Human     3 LPTCP---MAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCI 64

  Fly   177 ESKNKRAAKKTD---KKLPDPSQQHQQQQHQQQQQHQQHQQHQQAQTMLAGQLQSSVHVQQKFLK 238
            ::|.|||.|...   ...|.|:....:.......:|.:...|  ....:...|.|:...|.
Human    65 QAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATH--LHDTVKRNLDSATSPQN---- 123

  Fly   239 RPAEDVDNGPDSFEPPHKLPNNNNNSNSNNNNGNANANNG-GNGSNTGNNTNNNGNSTNNNGGSN 302
               .|..||.....|.||      .:......|.|.::|| ...|..|.:...:|.....:.|.:
Human   124 ---GDQQNGYGDLFPGHK------KTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKH 179

  Fly   303 NNGSENLTKFSVEIVQQLEFTTSAANSQPQQISTNVTVKALTNTSVKSEPGVGGGGGGGGGGGSG 367
            :.|.::|.|                             |.|.::|:
Human   180 SLGLDSLNK-----------------------------KRLADSSL------------------- 196

  Fly   368 NNNNNGGGGGGGNGNNNNNGGDHHQQQHQQQQQQQGGGLGGLGNNGRGGGPGGMATGPGGVAGGL 432
                            :.|||.:..:
Human   197 ----------------HLNGGSNPSE--------------------------------------- 206

  Fly   433 GGMGMPPNMMSAQQKSALGNLANLVECKREPDHDFPDL--GSLDKDGGGGQFPGFPDLLGDDNSE 495
               ..|.::..              |.|:||..|.|.:  |::   |...|....|||     :.
Human   207 ---SFPLSLNK--------------ELKQEPVEDLPCMITGTV---GSISQSNLMPDL-----NL 246

  Fly   496 NNDTFKDLINNL------QDFNPSFLDGFDEK--PLLDIKTEDGIKVEPPNAQDLINSLNVKSE- 551
            |...:|:||..|      :|....|.:.|:||  |     ...|...:.|.|||    :|:|:|
Human   247 NEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDP-----ESSGSATQTPLAQD----INIKTEF 302

  Fly   552 -----------------GGLGHGFGG---FGLGLDNPGMKMRGGNPG--NQGGFPNGPNGGTGGA 594
                             |..|..|.|   ..:..|:|.:   ||:..  :..|.|...|    .:
Human   303 SPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSL---GGSQTLFHTSGQPRADN----PS 360

  Fly   595 PN---------------AG------GNGGNSGNLMSEHPL----AAQTLKQMAEQHQHKN---AM 631
            ||               ||      |.||.| .|.|.|.|    |.|..:||.:..|...   |.
Human   361 PNLMPASAQAQNAQRALAGVVLPSQGPGGAS-ELSSAHQLQQIAAKQKREQMLQNPQQATPAPAP 424

  Fly   632 GGMGGFPR--PPHGM----NPQQQQQQQQQQQQQ----------------------QAQQQHGQM 668
            |.|..:.:  |.|..    .|.::.......:|.                      ..|..|..:
Human   425 GQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNL 489

  Fly   669 MGQGQPGRYN-----------DYGGGFP-----NDFGLGPNGPQQQQQA-QQQQPQQ-QHLPPQF 715
            :....|...|           |||...|     .|.|.|..|..|.:.| ....||| .|:.
Human   490 LSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALMAYLPQQLSHIS--- 551

  Fly   716 HQQKG-------PG---------PGAGMN-----VQQNFLDIKQE----LFYSSQNDFDLKRLQQ 755
            |:|..       ||         ||...|     ||.....:..:    ...||.|.......||
Human   552 HEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLSSQQ 616

  Fly   756 QQAMQQQQQQQHHQQQQQQQQPKMGGVPNFNKQQQQQQVPQQQLQQQQQQQQQQQ-------QQQ 813
            |.|:.:|.|....||:|::||.|       :.||||....||.|..:|::||.|:       |.|
Human   617 QAAVMKQHQLLLDQQKQREQQQK-------HLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQ 674

  Fly   814 QQQYSPFSNQ-----NPNAAANFLN--------CP---PRGG---PNGNQQPGNLAQQQQQPGAG 859
            ......|..|     ..:||...:|        ||   |:.|   |.|   ||:.:.......:|
Human   675 DPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMPMG---PGHASVSSLPTNSG 736

  Fly   860 PQQQQQRGNAA-NGQQNNPNAGPGGNTPNAPQ---QQQQQSTTTTLQMKQTQQLHISQQGGGAH- 919
               ||.||.|. .|.||.|.:...|......|   |...|:|                 .|.||
Human   737 ---QQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQAT-----------------NGHAHI 781

  Fly   920 GIQVSAGQHLHLSGDMKSNVSVAAQQGVFFSQQQAQQQQQ-QQQPGGTNGPNPQQQQQQPHGGNA 983
            ..|.:.||:        ::||.|..|....|...:||..: ...||.|..|.|:
Human   782 PRQTNVGQN--------TSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPR----------- 827

  Fly   984 GGGVGVGVGVGVGNGGPNPG-QQQQQPN---QNMSNANVPSDGFSLSQSQSMNFNQQQQ---QQA 1041
                     |....||.|.. |.|..||   |...|:||  ..|:.:.|    |:.|||   :.:
Human   828 ---------VSPAMGGQNSSWQHQGMPNLSGQTPGNSNV--SPFTAASS----FHMQQQAHLKMS 877

  Fly  1042 AAQQQQVQPNMRQRQTQAQAAAAAAAAAAQAQAAANASGPNVPLMQQPQVGVGVGVGVGVGVGVG 1106
            :.|..|..||.......:.||..:......||...:|..| .|....||.|:
Human   878 SPQFSQAVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAP-APPPTAPQQGL------------- 928

  Fly  1107 NGGVVGGPG--SGGPNNGAMNQMGGPMGGMPGMQMGGPMNPMQMNPNAAGP--TAQQMMMGSGAG 1167
                   ||  ..||..||.:|       .|..||||...   ::...|.|  ||.|.:..:.:|
Human   929 -------PGLSPAGPELGAFSQ-------SPASQMGGRAG---LHCTQAYPVRTAGQELPFAYSG 976

  Fly  1168 GPG 1170
            .||
Human   977 QPG 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mam	NP_001286401.1	MamL-1	127..183	CDD:286652	21/59 (36%)
MAML1	NP_055572.1	Required for interaction with NOTCH proteins. /evidence=ECO:0000269\|PubMed:11101851	1..123		34/124 (27%)
		MamL-1	14..71	CDD:286652	21/56 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..184		27/133 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..487		50/240 (21%)
		TFIIA	271..>439	CDD:281188	46/184 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..617		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..681		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..953		54/210 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000