Protein Alignment mam and MAML2

DIOPT Version :10

• Sequence 1: NP_525115.1
• Gene: mam / 36555
• FlyBaseID: FBgn0002643
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_115803.1
• Gene: MAML2 / 84441
• HGNCID: 16259
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1662
• Identity: 358/1662 - (21%)
• Similarity: 489/1662 - (29%)
• Gaps: 689/1662 - (41%)

  Fly    96 GGIAGITGGNGAGGPTNPGAVPTAPGDTMPTKRMPVVDRLRRRMENYRRRQTDCVPRYEQAFNTV 160
            ||:.|.:|....||           |...|.....:|:|||.|:...|:....|..|||:.....
Human    12 GGLGGASGAGLLGG-----------GSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAES 65

  Fly   161 CEQQNQETTVLQKRFLESKNKRAAKKTDKKL----------PDPSQQHQQQQ-------HQQQQQ 208
            .:::.:.|..|.......:..|.|.|..|..          |.|:......|       ......
Human    66 SDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDY 130

  Fly   209 HQQHQQHQQAQTMLAGQLQSSVHVQQKFLKRPAEDVDNGPDSFEPPHKLPNNNNNSNSNNNNGNA 273
            |..||||                                         |.|::||..|...||..
Human   131 HHHHQQH-----------------------------------------LLNSSNNGGSGGINGEQ 154

  Fly   274 N--ANNGGNGSNTGNNTNNNGNSTNNNGGSNNNGSENLTKFSVEIVQQLEFTTSAANS-QPQQIS 335
            .  |:..|:..|:.                       |......:.::.....|.||| :|....
Human   155 QPPASTPGDQRNSA-----------------------LIALQGSLKRKQVVNLSPANSKRPNGFV 196

  Fly   336 TN--VTVKALTNTSVKSEPGVGGGGGGGGGGGSGNNNNNGGGGGGGNGNNNNNGGDHHQQQHQQQ 398
            .|  :.:|.:.                     .|.|.:.|.|     |...|||          |
Human   197 DNSFLDIKRIR---------------------VGENLSAGQG-----GLQINNG----------Q 225

  Fly   399 QQQQGGGLGGLGNNGRGGGPGGMAT------------GPGGVAGGLGGMGMPPNMMSAQQKSALG 451
            .|...|.|           |...|.            .||   .||..||
Human   226 SQIMSGTL-----------PMSQAPLRKTNTLPSHTHSPG---NGLFNMG--------------- 261

  Fly   452 NLANLVECKREPDHDFPDLGSLDK--DGGGGQFPGFPDLLGDDNSEN--NDTFKDLINNLQDFNP 512
                |.|.|:||....    |..|  ||...|...||:..|||..|.  :...::|.|.|.:.:
Human   262 ----LKEVKKEPGETL----SCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNIS- 317

  Fly   513 SFLDGFDEKPLLDIKTED----GIKVEPPNAQDL--------------INSLNVKSEGGLGHGFG 559
                   ..|:.|::.|:    .||.:.|...||              :..:.:|||
Human   318 -------VPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSE-------- 367

  Fly   560 GFGLGLDNPGMKMRGGNPGNQGGFPNGPNGGTGGAPNAGGNGGNSGN--LMSEHPLAAQTLKQMA 622
                  .:||:             ..||:|.....|.:.|...:..|  |.:..|:.:..    .
Human   368 ------YSPGL-------------TQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVP----Q 409

  Fly   623 EQHQHKNAMGGMGGFPRPPHGMNPQQQQQ----QQQQQQQQQAQQQHGQMMGQGQPGRYNDYGGG 683
            .|.|.:...|.....|......:.||.:|    :||..:.||.||||       ||..::    .
Human   410 SQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQH-------QPTNWS----A 463

  Fly   684 FPNDFGLGPNGPQQQQQAQQQQPQQQHLPPQFHQQKGPGPG-----------------AGMNVQQ 731
            .|:..|..| ||..|::.......||...|    |..|.||                 ||.:.|.
Human   464 LPSSAGPSP-GPFGQEKIPSPSFGQQTFSP----QSSPMPGVAGGSGQSKVMANYMYKAGPSAQG 523

  Fly   732 NFLDIKQELFYSSQNDFDLKRL---QQQQAMQQQQQQ-----QHHQQQQQQQQPKMGGVPNFNK- 787
            ..||:..:     |...||.|.   ....||:.:|..     ..:..|..||.|.:  :|:.||
Human   524 GHLDVLMQ-----QKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSV--LPSQNKP 581

  Fly   788 ------QQQQQQVPQQQLQQQQQQQQQQQQQQQQQYSPFSNQNPNAAANFLNCPPRGGPNGNQQP 846
                  ||||||..|||.|||||||||||||||||
Human   582 SLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ------------------------------ 616

  Fly   847 GNLAQQQQQPGAGPQQQQQRGNAANGQQNNPNAGPGGNTPNAPQQQQQQSTTTTLQMKQTQQLHI 911
                |||||.....|||||:.::.:.||               ||||||
Human   617 ----QQQQQSSISAQQQQQQQSSISAQQ---------------QQQQQQ---------------- 646

  Fly   912 SQQGGGAHGIQVSAGQHLHLSGDMKSNVSVAAQQGVFFSQQQAQQQQQQQQPGGTNGPNPQQQQQ 976
                                                  .|||.||||||||         |||||
Human   647 --------------------------------------QQQQQQQQQQQQQ---------QQQQQ 664

  Fly   977 QPHGGNAGGGVGVGVGVGVGNGGPNPGQQQQQPNQNMSNANVPSDGFSLSQSQSMNFNQQQQQQA 1041
            ||....|                      |..|:|.:..:.:|       ..|.:...|.|.|..
Human   665 QPSSQPA----------------------QSLPSQPLLRSPLP-------LQQKLLLQQMQNQPI 700

  Fly  1042 AAQQQQVQPNMRQRQTQAQAAAAAAAAAAQAQAAANASGPNVPLMQQPQVGVGVGVGVGVGVGVG 1106
            |....||  :.:|||.|....         .|....:..||
Human   701 AGMGYQV--SQQQRQDQHSVV---------GQNTGPSPSPN------------------------ 730

  Fly  1107 NGGVVGGPGSGGPNNGAMNQMGGPMGGMPGMQMGGPMNPMQ--MNPNAAG--PTAQQMMMGSGAG 1167
                   |.| .||.|:                 |.||..|  :|....|  .|.|:.:|
Human   731 -------PCS-NPNTGS-----------------GYMNSQQSLLNQQLMGKKQTLQRQIM----- 765

  Fly  1168 GPGQVPGPGQGPNPNQAKFLQQQQMMRAQAMQQQQQ---HMSGARPPPPEYNATKAQLMQAQMMQ 1229
                        ...|...||||.:..|:.:..|.|   |:|   .|||:|...:..:...|...
Human   766 ------------EQKQQLLLQQQMLADAEKIAPQDQINRHLS---RPPPDYKDQRRNVGNMQPTA 815

  Fly  1230 QTVGGG--------------------------------GVGVGGVGVGVGVGGVGGANGGRFPNS 1262
            |..||.                                |..:..:...|...|:.|......||:
Human   816 QYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNT 880

  Fly  1263 AAQAAAMRRMTQQPIP------PSGPMM-RPQHAMYMQQHGGAGGGPRTGMGV-PYGGGAGGPMG 1319
            .:..:.|.::|||..|      .:.||| ||...           ||.....| .:|.|:.|
Human   881 YSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTL-----------GPSNNNNVATFGAGSVG--- 931

  Fly  1320 GPQQQQRPPNVQVTPDGMPMGSQQEWRHMMMTQQQTQMGFGGPGPGGPMRQGPGGFNGGNFMPNG 1384
              ..||..||:..:...||   .|...::|:|...|...:.  ...|..:|.....:.|...|.|
Human   932 --NSQQLRPNLTHSMASMP---PQRTSNVMITSNTTAPNWA--SQEGTSKQQEALTSAGVRFPTG 989

  Fly  1385 AP---------NGAAGSGPNAGGMMSGPNVPQMQLTPAQMQQQLMRQQQQQQQQQQQHMGPGAAN 1440
            .|         ..|.||...:...::.||    |||||   .|:....|..|....|.|||....
Human   990 TPAAYTPNQSLQQAVGSQQFSQRAVAPPN----QLTPA---VQMRPMNQMSQTLNGQTMGPLRGL 1047

  Fly  1441 NMQMQQLLQQ-----QQSGGGGNMMASQMQMTSMHMTQTQQQITMQQQQQFVQSTTTTTHQQQQM 1500
            |::..||..|     .|||.|.|                |.:..:.|......|...:.:|..:.
Human  1048 NLRPNQLSTQILPNLNQSGTGLN----------------QSRTGINQPPSLTPSNFPSPNQSSRA 1096

  Fly  1501 MQMGPGGGGGGGGPGSANNNNGGGGGGAAGGGNSASTIASASSISQTINSVVANSNDFGLEFL-- 1563
            .|                             |..                   :|:|...:||
Human  1097 FQ-----------------------------GTD-------------------HSSDLAFDFLSQ 1113

  Fly  1564 --DNLPVDSNFSTQDLINSL-----DNDNFNLQDFNM 1593
              ||:....| |..|.|:||     .||:: ::|.|:
Human  1114 QNDNMGPALN-SDADFIDSLLKTEPGNDDW-MKDINL 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mam	NP_525115.1	MamL-1	126..183	CDD:462834	12/56 (21%)
MAML2	NP_115803.1	MamL-1	33..88	CDD:462834	12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..165		21/124 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..359		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..506		40/169 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..630		47/139 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..680		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	705..743		15/97 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..820		10/38 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1100		10/85 (12%)