Protein Alignment mam and Maml2

DIOPT Version :10

• Sequence 1: NP_525115.1
• Gene: mam / 36555
• FlyBaseID: FBgn0002643
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: XP_008764219.2
• Gene: Maml2 / 689844
• RGDID: 1587536
• Length: 1143
• Species: Rattus norvegicus
• Alignment Length: 1668
• Identity: 349/1668 - (20%)
• Similarity: 479/1668 - (28%)
• Gaps: 714/1668 - (42%)

  Fly    96 GGIAGITGGNGAGGPTNPGAVPTAPGDTMPTKRMPVVDRLRRRMENYRRRQTDCVPRYEQAFNTV 160
            ||:.|.:|....||           |...|.....:|:|||.|:...|:....|..|||:.....
  Rat    12 GGLGGASGAGLLGG-----------GSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAES 65

  Fly   161 CEQQNQETTVLQKRFLESKNKRAAKK----------TDKKLPDP------SQQHQQQQHQQQQQH 209
            .:::.:.|..|.......:..|.|.|          |....|.|      ||............|
  Rat    66 SDRERESTMQLLSLVQHGQGARKASKHAKATATTATTTAPPPPPTAPPVASQAASTAPPPPPDYH 130

  Fly   210 QQHQQHQQAQTMLAGQLQSSVHVQQKFLKRPAEDVDNGPDSFE--PPHKLPNNNNNSNSNNNNGN 272
            ..||||         :|.|:               |||..:.|  ||...|.:..||......|:
  Rat   131 HHHQQH---------RLTSN---------------DNGGINREQQPPASTPGDQRNSALLALQGS 171

  Fly   273 ANANNGGNGSNTGNNTNNNGNSTNNNGGSNNNGSENLTKFSVEIVQQLEFTTSAANSQPQQISTN 337
            .......|.|        ..||...||..:                                |:.
  Rat   172 LKRKQIVNLS--------PANSKRPNGFPD--------------------------------SSF 196

  Fly   338 VTVKALTNTSVKSEPGVGGGGGGGGGGGSGNNNNNGGGGGGGNGNNNNNGGDHHQQQHQQQQQQQ 402
            :.:|.:.                     .|.|.:.|.|     ....|||..|
  Rat   197 LDIKRIR---------------------VGENFSTGQG-----SLPVNNGQSH------------ 223

  Fly   403 GGGLGGLGNNGRGGGPGGMATGPGGVAGGLGGMGMPPNMMSAQQKSAL--------GNLAN--LV 457
                              |..||           :|.|....::.:||        .||.|  |.
  Rat   224 ------------------MMPGP-----------LPMNQAPLRKTNALPPSAHSPGNNLFNMGLK 259

  Fly   458 ECKREPDHDFPDLGSLDK--DGGGGQFPGFPDLLGDDNSEN--NDTFKDLINNLQDFNPSFLDGF 518
            |.|:||....    |..|  |....|...|.:..|||..:.  :...::|.|.|.:.:
  Rat   260 EVKKEPGETL----SCSKHMDDQLTQESVFTNRFGDDPGDQLMDPELQELFNELTNIS------- 313

  Fly   519 DEKPLLDIKTED----GIKVEPPNAQDL--------------INSLNVKSEGGLGHGFGGFGLGL 565
             ..|:.|::.|:    .||.:.|...||              ::.:.:|||
  Rat   314 -VPPMSDLELENMINATIKQDDPFGIDLGQQSQRSTPRPSLPMDKIIIKSE-------------- 363

  Fly   566 DNPGMKMRGGNPGNQGGFPNGPNGGTGGAPNAGG--NGGNSGNLMSEHPLAAQTLKQMAEQHQHK 628
            .:||:     .||:....|          |:||.  :..||. |.:..|:  .|:.|...|.|
  Rat   364 YSPGL-----TPGSPQLRP----------PSAGPAFSLANSA-LSTSSPI--PTVPQSQPQLQ-- 408

  Fly   629 NAMGGMGGFPRPPHGMNPQQQQQQQQQQQQQQA--QQQHGQMMGQGQPGRYNDYGGGFPNDFGLG 691
                .:.|..|.|    |..|:....||.:|.|  :|||.:|.
  Rat   409 ----TVSGASRAP----PSWQEVSHAQQLKQIAANRQQHVRMQ---------------------- 443

  Fly   692 PNGPQQQQQAQQQQPQQQHLPPQF---HQQKGPGPGAGMNVQQNFLDIKQELF----------YS 743
                |||||.||||.|||..||.:   ....||.|||.:..:.......|:.|          ..
  Rat   444 ----QQQQQQQQQQQQQQQPPPSWPALQSSAGPSPGAFVQEKIPSPSFGQQPFSPQGSPMPGVTG 504

  Fly   744 SQNDFDLKRLQQQQA------MQQQQQQQH-----HQQQQQQQ-----------QPKMGGVP--- 783
            |.|       |.:.|      .....|..|     ||:.|...           :|:.|...
  Rat   505 SSN-------QSKAAGNYTYKASPSAQTGHLDVLLHQKPQDLSRGFINNPHPTLEPRHGNTKPLF 562

  Fly   784 NFNKQQQQQQVPQQQ-------LQQQQQQQQQQQQQQQQQYSPFSNQNPNAAANFLNCPPRGGPN 841
            :||..|..||:|.|.       .||||.|.|.|.||||||
  Rat   563 HFNSDQANQQMPSQSKPSLLHYTQQQQPQLQPQSQQQQQQ------------------------- 602

  Fly   842 GNQQPGNLAQQQQQPGAGPQQQQQRGNAANGQQNNPNAGPGGNTPNAPQQQQQQSTTTTLQMKQT 906
                     |||||    .|||||:|:.|                 |.||||.||
  Rat   603 ---------QQQQQ----QQQQQQQGSLA-----------------AQQQQQAQS---------- 627

  Fly   907 QQLHISQQGGGAHGIQVSAGQHLHLSGDMKSNVSVAAQQGVFFSQQQAQQQQQQQQPGGTNGPNP 971
                                             |:|||      |||.||||||||
  Rat   628 ---------------------------------SLAAQ------QQQQQQQQQQQQ--------- 644

  Fly   972 QQQQQQPHGGNAGGGVGVGVGVGVGNGGPNPGQQQQQPNQNMSNANVPSDGFS--------LSQS 1028
            ||||||                          ||||||:|       |:...|        |...
  Rat   645 QQQQQQ--------------------------QQQQQPSQ-------PTQALSSQPLLRSPLPLQ 676

  Fly  1029 QSMNFNQQQQQQAAAQQQQVQPNMRQRQTQAQAAAAAAAAAAQAQAAANASGPNVPLMQQPQVGV 1093
            |.:...:.|.|..|....||....||.|     .:....:...:.:..:.|.||.
  Rat   677 QKIMLQKMQNQSIAGLGYQVTQQHRQDQ-----HSVVGQSTGPSPSPNSCSNPNT---------- 726

  Fly  1094 GVGVGVGVGVGVGNGGVVGGPGSGGPNN--GAMNQMGGPMGGMPGMQMGGPMNPMQMNPNAAGPT 1156
                                 |||..|:  ..:||           ||.|....:|.      ||
  Rat   727 ---------------------GSGYMNSQQSLLNQ-----------QMMGKKQTLQR------PT 753

  Fly  1157 AQQMMMGSGAGGPGQVPGPGQGPNPNQAKFLQQQQMMRAQAMQQQQQHMSGARPPPPEYNATKAQ 1221
            .:|                      .|...||||.:..|:.:..|.|.......|||:|...:..
  Rat   754 MEQ----------------------KQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRN 796

  Fly  1222 LMQAQMMQQTVGG--------------------------------GGVGVGGVGVGVGVGGVGGA 1254
            ....|...|..||                                .|:.:..:.....:|..|..
  Rat   797 AGSLQPAAQYSGGPSSVSLNSNQALTNPVSTHTILTSNSSLMSTSHGMRMPLLSTVQNIGMYGNL 861

  Fly  1255 NGGRFPNSAAQAAAMRRMTQQ------------PIPPSGPMMRPQHAMYMQQHGGAGGGPRTGMG 1307
            ...: |.:.:..:||.::|||            |:.|..|.:           |.:.|......|
  Rat   862 PCNQ-PGTYSVTSAMNQLTQQRNTTQLITNQNNPLMPRPPPL-----------GASTGNNAAAFG 914

  Fly  1308 VPYGGGAGGPMGGPQQQQRPPNVQVTPDGMPMGSQQEWRHMMMTQQQTQMGFGGPGPGGPMRQG- 1371
                   .||.|.|||.:  ||:.....||   :.|....:|:|...|...:......|..::.
  Rat   915 -------AGPAGSPQQLR--PNLAHGLAGM---TAQRSSTVMITASTTATNWASQEVTGKQQEAL 967

  Fly  1372 -PGGFNGGNFMPNGAPNGAAGSGPNAGGMMSGPNVPQMQLTPAQMQQQLMRQQQQQQQQQQQHMG 1435
             |.|.......|...||.:...|..:.........|..|||||   .|:....|..|....|.:|
  Rat   968 KPTGVRFPTSTPAYTPNQSLQPGVGSQPFSQRAVAPPSQLTPA---VQMRPVNQMNQTLNGQTLG 1029

  Fly  1436 PGAANNMQMQQLLQQQQSGGGGNMMASQMQMTSMHMTQTQQQITMQQQQQFVQSTTTTTHQQQQM 1500
            |....|::..||                                             ||   |.:
  Rat  1030 PLRGLNLRPNQL---------------------------------------------TT---QNL 1046

  Fly  1501 MQMGPGGGG------GGGGPGSANNNNGGGGGGAAGGGNSASTIASASSISQTINSVVANSNDFG 1559
            ..|.|.|.|      |...|.|...|                |..|::..|:.... ..:.:|..
  Rat  1047 SNMNPPGTGLNPPRTGANQPPSLTPN----------------TFPSSNQSSRAFQG-PDHGSDLA 1094

  Fly  1560 LEFL----DNLPVDSNFSTQDLINSL-----DNDNFNLQDFNM 1593
            .:||    |::....| |..|.|:||     .||:: ::|.|:
  Rat  1095 FDFLSQQSDSMGPALN-SDADFIDSLLKTEPGNDDW-MKDINL 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mam	NP_525115.1	MamL-1	126..183	CDD:462834	12/56 (21%)
Maml2	XP_008764219.2	MamL-1	33..88	CDD:462834	12/54 (22%)