Protein Alignment mam and Maml2

DIOPT Version :9

• Sequence 1: NP_001286401.1
• Gene: mam / 36555
• FlyBaseID: FBgn0002643
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_001013835.2
• Gene: Maml2 / 270118
• MGIID: 2389460
• Length: 1170
• Species: Mus musculus
• Alignment Length: 1454
• Identity: 327/1454 - (22%)
• Similarity: 430/1454 - (29%)
• Gaps: 526/1454 - (36%)

  Fly    96 GGIAGITGGNGAGGPTNPGAVPTAPGDTMPTKRMPVVDRLRRRMENYRRRQTDCVPRYEQAFNTV 160
            ||:.|.:|....||           |...|.....:|:|||.|:...|:....|..|||:.....
Mouse    12 GGLGGASGAGLLGG-----------GSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAES 65

  Fly   161 CEQQNQETTVLQKRFLESKNKRAAKK----------TDKKLPDP------SQQHQQQQHQQQQQH 209
            .:::.:.|..|.......:..|.|.|          |....|.|      ||............|
Mouse    66 SDRERESTMQLLSLVQHGQGARKASKHAKATVATATTTAPPPPPTAPPVASQAAATAPPPPPDYH 130

  Fly   210 QQHQQHQQAQTMLAGQLQSSVHVQQKFLKRPAEDVDNGPDSFE-PPHKLPNNNNNSN-------- 265
            ..||||         :|.|:               |||..:.| ||...|.:..||.
Mouse   131 HHHQQH---------RLTSN---------------DNGGINREQPPASTPGDQRNSALLALQGSL 171

  Fly   266 -----SNNNNGNANANNGGNGSN--------TGNNTNNNGNSTNNNGGSNNNGSENLTKFSVEIV 317
                 .|.:..|:...||...|:        .|.|.     ||...|...|||...:....:.:.
Mouse   172 KRKQIVNLSPANSKRPNGFVDSSFLDIKRIRVGENL-----STGQGGLPVNNGQSQMMPGPLTMN 231

  Fly   318 QQLEFTTSAANSQPQQISTNVTVKALTNTSVKSEPGVGGGGGGGGGGGSGNNNNNGGGGGGGNGN 382
            |.....|:|..........|:....|  ..||.|||
Mouse   232 QAPLRKTNALPPPAHSPGNNLFNMGL--KEVKKEPG----------------------------- 265

  Fly   383 NNNNGGDHHQQQHQQQQQQQGGGLGGLGNNGRGGGPGGMATGP--GGVAGGLGGMGMPPNMMSAQ 445
            ...:...|...|..|:         .:..|..|..||.....|  ..:...|..:.:||  ||..
Mouse   266 ETLSCSKHMSDQMTQE---------SVFTNRFGDDPGDQLMDPELQELFNELTNISVPP--MSDL 319

  Fly   446 QKSALGNLANLVECKREPDHDFP-DLGSLDKDGGGGQFPGFPDLLGDDNSENNDTFKDLINNLQD 509
            :      |.|::....:.|..|. |||  .:.......|..|            ..|.:|.:  :
Mouse   320 E------LENMINATIKQDDPFGIDLG--QQSQRSTPRPSLP------------MEKIIIKS--E 362

  Fly   510 FNPSFLDGFDEKPLLDIKTEDGIKVEPPNAQDLINSLNVKSEGGLGHGFGGFGLGLDNPGMKMRG 574
            ::|....|....|          ::.||:|             |.........|...:|
Mouse   363 YSPGLTQGTSGSP----------QLRPPSA-------------GPAFSLANSALSTSSP------ 398

  Fly   575 GNPGNQGGFPNGPNGGTGGAPNAGGNGGNSGNLMSEHPLAAQTLKQMAEQHQHKNAMGGMGGFPR 639
                    .|..|.........:|.|...|......|   ||.|||:|...|
Mouse   399 --------IPTIPQSQPQLQTVSGANRALSSWQEVSH---AQQLKQIAANRQ------------- 439

  Fly   640 PPHGMNPQQQQQQQQQQQQQQAQQQHGQMMGQGQPGRYNDYGGGFPNDFGLGPNGPQQQQQAQQQ 704
                .:.:.||||||||||........|......||.:                       .|::
Mouse   440 ----QHARMQQQQQQQQQQPSPSWPALQSSAGPSPGAF-----------------------VQEK 477

  Fly   705 QPQQQHLPPQFHQQKGPGPG-----------------AGMNVQQNFLDI-----KQEL------- 740
            .|........|..|..|.||                 |..:.|...||:     .|||
Mouse   478 IPSPSFSQQPFSPQGSPMPGVTGSNTQSKAAANYTYKASPSAQAGHLDVLLQQKPQELNRSFINN 542

  Fly   741 -----------------FYSSQNDFDLKRLQQQQA-------MQQQQQQQHHQQQQQQQQPKMGG 781
                             |.|.|.:..:..|...|:       .|||||||..||||||||
Mouse   543 PHPALEPRHGNTKPLFHFNSDQANQQMPSLLPSQSKPSLLHYTQQQQQQQQQQQQQQQQQ----- 602

  Fly   782 VPNFNKQQQQQQVPQQQLQQQQQQQQQQQQQQQQQYSPFSNQNPNAAANFLNCPPRGGPNGNQQP 846
                  ||||||..|||.|||||||||||||||||
Mouse   603 ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQ------------------------------ 631

  Fly   847 GNLAQQQQQPGAGPQ-----QQQQRGNAANGQQNNPNAGPGGNTPNAPQQQQQQSTTTTLQMKQT 906
            |:||.||||....||     ||||:      ||.              ||||||.:.|..|.:|.
Mouse   632 GSLAAQQQQQQPQPQSSLVAQQQQQ------QQQ--------------QQQQQQGSLTAQQQQQQ 676

  Fly   907 QQLHISQQGGGAHGIQVSAGQHLH-LSGDMKSNVSVAAQQGVFFSQQQAQQQQQQQQPGGTNGPN 970
            ||             |....|..| ||........:..||.:..      |:.|.|...|.....
Mouse   677 QQ-------------QQQPSQPTHALSSQPLLRSPLQLQQKIML------QKMQTQSITGLGYQV 722

  Fly   971 PQQQQQQPHGGNAGGGVGVGVGVGVG-NGGPNPGQQQQQPNQNMSNANVPSDGFSLSQSQSMNFN 1034
            .||.:|..|             ..|| |.||:|     .|| :.||.|..| |:..||...:|
Mouse   723 TQQHRQDQH-------------TVVGQNTGPSP-----SPN-SCSNPNTGS-GYMNSQQSLLN-- 765

  Fly  1035 QQQQQQAAAQQQQVQPNMRQRQ---TQAQAAAAAAAAAAQAQAAANASGP---------NVPLMQ 1087
               ||....:|...:|.|.|:|   .|.|..|.|...:.|.|...:.:.|         |...:
Mouse   766 ---QQMMGKKQTLQRPTMEQKQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRNTGTL- 826

  Fly  1088 QPQVGVGVGVGVGVGVGVGNGGVVGGPGSG----GPNNGAMN-------------QMGGPMGGMP 1135
            ||......|...   |.:.:...:..|.|.    .||:..|:             |..|..|.:|
Mouse   827 QPAAQYSGGSST---VSLNSNQALTNPVSTHTILTPNSSLMSTSHGMRMPLLSTVQNIGMYGNLP 888

  Fly  1136 GMQMG----------------------GPMNPMQMNPNAAGPTAQQMMMGSGAGGPGQVPGPGQG 1178
            ..|.|                      ...||:...|:..|......:...|||..|.    .|.
Mouse   889 CNQPGTYNVTSTMNQLTQQRNTTQLITNQNNPLMSRPSPLGANNGNNVATFGAGSAGS----SQQ 949

  Fly  1179 PNPNQAKFLQQQQMMRAQAMQQQQQHMSGARPPPPEYNATKAQLMQAQMMQQTVGGGGVGVGGVG 1243
            ..||.|..|......|:..:      |..|......:.:.:....|.:.::.|
Mouse   950 LRPNLAHSLSGMSAQRSSTV------MITANTTATNWASQEVTGKQQEALKST------------ 996

  Fly  1244 VGVGVGGVGGANGGRFPNSAAQAAAMRRMTQ-----QPI------PPS----GPMMRPQHAMYMQ 1293
                        |.|||.|...|....:..|     ||.      |||    ...|||.:.|...
Mouse   997 ------------GVRFPTSTPAAYTPNQSLQPGVGSQPFSQRAVAPPSQLSPAVQMRPMNQMNQA 1049

  Fly  1294 QHGGAGGGPRTGMGV--------------PYGGGAGGPMGGPQQQQRPPNVQVTPDGMPMGSQQE 1344
            .:|...|..| |:.:              |.|.|...|..|..|   ||:  :||:..|
Mouse  1050 LNGQTLGSLR-GLNLRPNQLAAQSLSNMNPSGTGLNHPRTGTNQ---PPS--LTPNAFP------ 1102

  Fly  1345 WRHMMMTQQQTQMGFGGPGPGGPM 1368
                  :..|:...|.||..|..:
Mouse  1103 ------SSNQSSRAFQGPDHGSDL 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mam	NP_001286401.1	MamL-1	127..183	CDD:286652	12/55 (22%)
Maml2	NP_001013835.2	MamL-1	33..88	CDD:286652	12/54 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000