DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctf4 and CTF4

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_015461.1	Gene:	CTF4 / 856254	SGDID:	S000006339	Length:	927	Species:	Saccharomyces cerevisiae

Alignment Length:	990	Identity:	200/990 - (20%)
Similarity:	343/990 - (34%)	Gaps:	313/990 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SALRYAHTNGYTGLLYTPRGE----------------------FIITCGTDGDIRHWTCISDDDP 48
            :.|..|:.||.|.:|.|...|                      |::|. ..||...:..   |..
Yeast    25 NTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTT-MQGDALRYNI---DSS 85

  Fly    49 RSSCLGEFVM-----CIAHTGTR----------LLASTDRNT--IHAYTFPEMDSDGILMRFTAP 96
            :...|..|.:     |:.|:|..          :|...|..|  .||....|..|.   :.:.:.
Yeast    86 QEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQ---ISYNSQ 147

  Fly    97 ATCLKVS----------------------GGYTAAGSEDTT--IKVLK---------GDTAGNET 128
            ...|.||                      ..|..|.|.|.|  .|:|.         .|...:||
Yeast   148 MNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSET 212

  Fly   129 VLEGHTGPILALDLFAERKLLVSVA------------GDGQLKVWNFEEGKELKTIGGLPKVNSF 181
            . :.....:...:..|..::...||            .|..:|:::.:.....||:
Yeast   213 A-DPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTL--------- 267

  Fly   182 ESASLYGTP------HFEPQSGELLAYAVD--NEIVVLNTANWE----------------VAFKL 222
             |.:|..|.      .|:|..|..:| |||  |::.|.   |||                :|:|:
Yeast   268 -STNLSSTKAHFIDLQFDPLRGTYIA-AVDLNNKLTVW---NWETSEIHYTREFKRKITNIAWKI 327

  Fly   223 RDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVKKRKAVTVEIPPSDCNAITCLAWNLSGEVE 287
            :.||.:.:            |..||..|.::|.. ...::|...||                  :
Yeast   328 QADSKTLD------------LVLGTWSGSIAIVQ-NLAESVVSNIP------------------D 361

  Fly   288 VAFCDATGQLGTVFLGDAVDTGNGDGLVD-DQAELLGDDYEFEA-GDDVDTAADDG-DGVSLEQL 349
            .:..:::.:.| :|:....|..|.:|..| ::::.|..|...|| .:||.|...|| .|:|
Yeast   362 QSVAESSTKHG-LFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLS---- 421

  Fly   350 KRKVMNFADP---VDHDDAS------------NQSLDSSSRTVPAPVAPQIKLFKQQTAFQPSAT 399
            :::..||.|.   :|.||.:            :.|....:.:.|..:|...|.  :...|.|:.|
Yeast   422 EKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKF--RYMPFSPAGT 484

  Fly   400 PADL-EHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALAS 463
            |... :.||:..|:||.|:. |:.|...||.|.|.|.......|..:...::|..::........
Yeast   485 PFGFTDRRYLTMNEVGYVST-VKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQ 548

  Fly   464 NESSKLVVIALAAAGNKEWSLSLP--DCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTI 526
            :::.::......:. :..|:..:|  ..|...:|.||...|.|.||..:.|.|...|       :
Yeast   549 SKTGQIQYRPHDSI-HSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFG-------V 605

  Fly   527 P------GPMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEY---LPVPLT---- 578
            |      .|:||:....:.:..|::|      |.|..:..::..|.|.::.|   .|:|::
Yeast   606 PFAVEKTSPIVALTAQNYRVFSVHYS------QFHGLSYSLSELGTSSKRYYKRECPLPMSLPNI 664

  Fly   579 -----PGRQLTWFG----------YSDTGSPSI--ADNMGLLQLYRRS--SNAWFPICDTM---- 620
                 ....|.::.          :|..|.|.|  :||..||....||  .:.|.||.|:.
Yeast   665 NSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIW 729

  Fly   621 -----KQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPMTNPRPMLQELRMQIPL---------- 670
                 |::|.:    .|..::.....:..:|.:|.......|.|:..|:.:::|:
Yeast   730 KMSGGKETTDI----HVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEEN 790

  Fly   671 -----------CDVEVEKSE------------LEDALLRSSLM------------QMDGAEK--- 697
                       .|.|.|:.|            .|:..|||.::            :|.|.|.
Yeast   791 KAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVL 855

  Fly   698 -----MQKETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDR--LCELL 755
                 ...:..::|||.|||.:...:|..|...:.....|..|||         :|:|  |..|:
Yeast   856 AALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVK---------ISERAELPSLV 911

  Fly   756 PQLEAVQEARKQQTL 770
            .::..::|||.:|.|
Yeast   912 KKINNIREARYEQQL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	74/405 (18%)
		WD40	12..256	CDD:295369	67/351 (19%)
		WD40 repeat	16..52	CDD:293791	9/57 (16%)
		WD40 repeat	97..131	CDD:293791	13/66 (20%)
		WD40 repeat	138..173	CDD:293791	7/46 (15%)
		WD40 repeat	181..223	CDD:293791	17/65 (26%)
		WD40 repeat	231..268	CDD:293791	6/36 (17%)
		Mcl1_mid	393..670	CDD:289138	68/320 (21%)
CTF4	NP_015461.1	WD40 repeat	140..176	CDD:293791	4/38 (11%)
		WD40 repeat	180..231	CDD:293791	10/51 (20%)
		WD40	<233..347	CDD:421866	29/139 (21%)
		WD40 repeat	233..272	CDD:293791	7/48 (15%)
		WD40 repeat	279..311	CDD:293791	12/35 (34%)
		Mcl1_mid	478..779	CDD:403527	68/319 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55477
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R690
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.780