DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctf4 and AT3G42660

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_189852.2	Gene:	AT3G42660 / 823286	AraportID:	AT3G42660	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	967	Identity:	236/967 - (24%)
Similarity:	418/967 - (43%)	Gaps:	152/967 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRYAHTNG----YTGLLYTPRGE-FIITCGTDGDIRHWTCISDDDPRSSCL-----GEFVMCIAH 62
            ||.||..|    :..:|:..:.| |:.:..:|..|.....:|......:.|     |...:.:::
plant     8 LREAHKVGGSAAFCSILWDHKAEHFVTSSSSDPSISVHDGLSTSTLPPTILRHHQDGVTSLALSN 72

  Fly    63 TGTRLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKV--SGGYTAAGSEDTTIKVLKGDTAG 125
            ..|.|.:.:..:.:..|.||..:....:.|||.|...|..  ||...||..:|..||::......
plant    73 DSTLLASGSIDHCVKLYKFPSGEFQTNITRFTLPIRVLAFNGSGSLLAAAGDDEGIKLINTFDGS 137

  Fly   126 NETVLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTP 190
            ...||:||.||:..||.....:||.|:...|.:..|..:.|....|:.|:.....| :.|:...|
plant   138 IVRVLKGHKGPVTGLDFHPNGELLASIDTTGTVLCWELQNGVVSFTLKGVAPDTGF-NTSIVNIP 201

  Fly   191 HFEPQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCC--QFSPNGERLAAGTTKGEVS 253
            .:.|....|....:.|::|:.:....|..|.||.|.:.   :.|  .::|||:.:|......:|.
plant   202 RWSPDGRTLAVPGLRNDVVMYDRFTGEKLFALRGDHLE---AICYLTWAPNGKYIATSGLDKQVL 263

  Fly   254 IFDVKKRKAV---TVEIPPSDCNAITCLAWNLSGEVEVAFCDATGQLG-------------TVFL 302
            ::||.|::.:   ..|      ..|.|::|..:|.. ::..||.|:.|             ||.:
plant   264 LWDVDKKQDIDRHKFE------ERICCMSWKPNGNA-LSVIDAKGRYGVWESLVPSSMLSPTVGV 321

  Fly   303 GDAVDTGNGDGL-VDDQAELLGDDYEFEAGDDVDTA---ADDGDG--VSLEQLKRKVMNFADPVD 361
            .|.|.....:.| .||:.|    :..:.|.:.:|.|   :|||:.  .|.::|::|.:  .|. |
plant   322 PDIVPKKRNEILDFDDEVE----EEIYRASESLDDAMGDSDDGESHHTSRKRLRKKTL--IDE-D 379

  Fly   362 HDDASNQSLDSSSRTVPAPVAPQIK-------------------------LFKQQTAFQPSATPA 401
            .|||..:..|.||    .|.|.:.:                         .:|.|::|||.|||.
plant   380 VDDAYEELNDGSS----LPSASEYRKKSHRGHREKQGARSGAFKGISASTKYKMQSSFQPGATPP 440

  Fly   402 DLEHR-YMAWNDVGIVTAHVEPSGDSSIDVEFHDAS----IHHALHISNYNQHNLASVSSGALAL 461
            :...| ::.:|.:|.:|. :|..|:|.|:.:|||..    :...:.|..:   .:||::......
plant   441 EPGKRTFLCYNMLGCITT-IEHEGNSRIETDFHDTGRGPRVSSMIDIYGF---TMASINETGCVF 501

  Fly   462 AS---NESSKLVVI---ALAAAGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQ 520
            |:   .|.:..|::   ..:.|.|.||::.. :.|..:.|......||..||.:.||:|:..|.|
plant   502 ANPCKGEKNMSVLMYRPFRSWASNSEWTMRF-EGEEVKVVANGSGWVAAVTSLNLLRVFSEGGLQ 565

  Fly   521 REVLTIPGPMVAIAGHEHSLMVVYHSS--APSQTQQHLAAMLVNINGLSLRQEYL-PVPLTPGRQ 582
            :.:|::.||:|...|.:..|.||.|.|  .|| .:|.:...:.||:  .:.||.. .|.||||.:
plant   566 KHILSLDGPVVTAVGCKDHLAVVTHVSDCLPS-NEQVMEFRVFNIS--KMTQELKGRVALTPGSR 627

  Fly   583 LTWFGYSDTGSPSIADNMGLLQLY-RRSSNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVL 646
            |||.|:|:.||.|..|:.|:|::: .:...:|.|:..|.|:... ..|::||.::...  :..:.
plant   628 LTWIGFSEEGSLSSYDSEGVLRVFTSQYGGSWIPVFSTSKEKKQ-EENYWVVGLNTSS--LYCIA 689

  Fly   647 CR-GTSYPMTNPRPMLQELRMQIPLCDVEVEKSELEDALLRSSL-----------MQMDGA---- 695
            |: ...:|...|:|:|..|.:.:||...::..:.||:.|:...|           |.:.|.
plant   690 CKYAEMFPQVTPKPILTILDLSLPLASSDLGAASLENELILKQLRLYETQRKVDDMALVGVDTTA 754

  Fly   696 --------EKMQKETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLC 752
                    |..|.:..::|.:..|||:...||.||:|.:.....::.|:...||.....|:::..
plant   755 LEDEAFDLEVSQDKCILRLISSCCSSDSFARASELMELLTLEKSMRAAITLVTKLKLPFLAEKFS 819

  Fly   753 ELLPQ--LEAVQEARKQQTLLGASGIAATIV--LPMTPTSASQSGPKPKAIELSSAKRGTLKRLV 813
            .:|.:  ||...||......|..:|...|.|  ....|.::.|:....:|:..|||.:      :
plant   820 SILEERLLEEASEAAVTNPALNPNGEVVTRVESKVQNPPASIQTSENTEAVMKSSATK------L 878

  Fly   814 NSPNMFKAAAASAASRPSTPDITPSPLDTQENIFGESESEVPMGKATDHRSPLNSVN 870
            ::|.:.|.:..|...:...........|         ::::...|..:.::|:|:||
plant   879 SAPTLLKKSKVSEGLKLGKEQTKKDKSD---------DAKIKEIKKLNLKNPVNNVN 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	78/325 (24%)
		WD40	12..256	CDD:295369	61/257 (24%)
		WD40 repeat	16..52	CDD:293791	6/36 (17%)
		WD40 repeat	97..131	CDD:293791	9/35 (26%)
		WD40 repeat	138..173	CDD:293791	9/34 (26%)
		WD40 repeat	181..223	CDD:293791	9/41 (22%)
		WD40 repeat	231..268	CDD:293791	10/41 (24%)
		Mcl1_mid	393..670	CDD:289138	84/292 (29%)
AT3G42660	NP_189852.2	WD40	<48..307	CDD:225201	66/269 (25%)
		WD40	58..294	CDD:295369	61/246 (25%)
		WD40 repeat	65..102	CDD:293791	5/36 (14%)
		WD40 repeat	108..144	CDD:293791	10/35 (29%)
		WD40 repeat	149..185	CDD:293791	9/35 (26%)
		WD40 repeat	195..234	CDD:293791	8/38 (21%)
		WD40 repeat	241..274	CDD:293791	9/32 (28%)
		Mcl1_mid	432..714	CDD:289138	84/292 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I2142
eggNOG	1	0.900	-	-		E1_KOG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56019
Inparanoid	1	1.050	214	1.000	Inparanoid score	I1232
OMA	1	1.010	-	-		QHG55477
OrthoDB	1	1.010	-	-		D155530at2759
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	1	1.000	-	-		oto3011
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840