DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctf4 and Wdhd1

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	XP_006251857.1	Gene:	Wdhd1 / 305827	RGDID:	1310200	Length:	1119	Species:	Rattus norvegicus

Alignment Length:	956	Identity:	285/956 - (29%)
Similarity:	453/956 - (47%)	Gaps:	122/956 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGT 65
            |..::..:||.||.|:|.:.:...|.||:|||:|||:|.|..:.||||:|..:||.....|....
  Rat     1 MPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNG 65

  Fly    66 RLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKVSGGYT--AAGSEDTTIKVLKGDTAGNET 128
            :|:.:...||:..|||||...||||.|||..|..:..:|..|  ||||.|..:||:.......:.
  Rat    66 KLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQ 130

  Fly   129 VLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFE 193
            ...||..|:|:|....:...|.|.:.||.::|||..:.....:...|.|.|...::.......::
  Rat   131 TFRGHDAPVLSLSFDPKDVFLASASCDGTVRVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQ 195

  Fly   194 PQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVK 258
            |::|:.||..|:..:.:.....|...|.|.|.||:...:...:||.|:.||||...|.:.:::|:
  Rat   196 PKTGKFLAVPVEKSVKLYRRETWSNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVE 260

  Fly   259 KRKAVTVEIPPSDCNAITCLAW----------NLSGEVEVA--FCDATGQLGT------------ 299
            .::.:. .:......||..|||          ::.|.:.:.  .||.:|:|.:
  Rat   261 TKECME-RVKHEKGYAICGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYS 324

  Fly   300 -VFLGDAVDTGN-GDGLVDDQAEL----LGDDYEFEAGDDVDTAA-----DDGDGVSLEQLKRKV 353
             :|.||  ||.: ||.|.|:..|:    .|...|.:..||:..||     ||.:.|.:..|:..:
  Rat   325 DLFDGD--DTSSAGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDL 387

  Fly   354 MNFADPVDHDDASNQSLDSSSRTVPAPVAPQIKLF------KQQTAFQPSATPADLEHRYMAWND 412
                    |.:.......||..::|. |..|..|:      .:|..||||:||..|.||:||||.
  Rat   388 --------HREEGEDRQASSLHSLPL-VKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNS 443

  Fly   413 VGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALASNE----SSKLVVIA 473
            |||:..:.:.. ||:|||||||.|||||.|:||...:.:.|:|..|:.||...    :|||..:.
  Rat   444 VGIIRCYNDDQ-DSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLH 507

  Fly   474 LAA-AGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTIPGPMVAIAGHE 537
            .:: ..:|||.:.:|:.|..||:.......|.|||:..||:||:.|.|:||..:|||:|::|||.
  Rat   508 FSSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVVSMAGHG 572

  Fly   538 HSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYL---PVPLTPGRQLTWFGYSDTGSPSIADN 599
            ..|.:|||........|.|...|:.:.  ..:::.|   |:|||....|||.|:|..|:|...|:
  Rat   573 EQLCIVYHRGTGFDGDQCLGVQLLELG--RKKKQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDS 635

  Fly   600 MGLLQLYRRS-SNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPMTNPRPMLQE 663
            .|.:::..|. .|.|.|:|:..:.....|.:::||.:.|..|.::.:.|:|:.:|.|.|||.:..
  Rat   636 EGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAI 700

  Fly   664 LRMQIPLCDVEVEKSELEDALLRSSLMQ--MD---------------GAEKMQKETAIKLFALAC 711
            |..::|.|....||.::|:....|.|..  :|               .|.|.|:|..:|:.||:|
  Rat   701 LPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYDYEESIKKQAVKEQQELLMKMLALSC 765

  Fly   712 SSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCELLP---------QLEAVQEARKQ 767
            ..|.|.|..||.: :...:.:.||:|||::..::.|:.:|.||..         |.|..:|..::
  Rat   766 KLEREFRCVELAD-LMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAEIQTEEREEDFRE 829

  Fly   768 QTLLGASGIAATIVLPMTPTSASQSGPKPKAIELSSAKRGTL-------KRLVNSPNMFKAAAAS 825
            :...|.|         .|.|..||...:.:..|.:..:..|:       :..|...|:.::|.:|
  Rat   830 RLNAGYS---------HTTTEWSQPRVRSQVEEDAEDREDTVSEGNPEPQNHVIGQNLIQSANSS 885

  Fly   826 AASRPSTPDITPSPLDTQENIFGESESEV-PMGKATDHRSPLNSVN 870
                 .||.:....      :|..|:..| |.......:.|..|||
  Rat   886 -----DTPAMKSGA------VFSSSQGRVNPFKVLVSSKEPAVSVN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	97/329 (29%)
		WD40	12..256	CDD:295369	82/245 (33%)
		WD40 repeat	16..52	CDD:293791	17/35 (49%)
		WD40 repeat	97..131	CDD:293791	10/35 (29%)
		WD40 repeat	138..173	CDD:293791	9/34 (26%)
		WD40 repeat	181..223	CDD:293791	7/41 (17%)
		WD40 repeat	231..268	CDD:293791	9/36 (25%)
		Mcl1_mid	393..670	CDD:289138	106/285 (37%)
Wdhd1	XP_006251857.1	WD40	10..289	CDD:238121	89/279 (32%)
		WD40	<11..297	CDD:225201	89/286 (31%)
		WD40 repeat	21..54	CDD:293791	16/32 (50%)
		WD40 repeat	59..92	CDD:293791	13/32 (41%)
		WD40 repeat	97..133	CDD:293791	10/35 (29%)
		WD40 repeat	140..175	CDD:293791	9/34 (26%)
		WD40 repeat	184..225	CDD:293791	7/40 (18%)
		WD40 repeat	233..269	CDD:293791	9/36 (25%)
		WD40 repeat	276..299	CDD:293791	5/22 (23%)
		Mcl1_mid	424..706	CDD:289138	106/284 (37%)
		HMG	1007..>1060	CDD:197700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352247
Domainoid	1	1.000	197	1.000	Domainoid score	I3013
eggNOG	1	0.900	-	-		E1_KOG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56019
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1966
OMA	1	1.010	-	-		QHG55477
OrthoDB	1	1.010	-	-		D155530at2759
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	1	1.000	-	-		oto98309
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770