DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ctf4 and Wdhd1

DIOPT Version :10

Sequence 1:NP_610921.1 Gene:Ctf4 / 36551 FlyBaseID:FBgn0033890 Length:895 Species:Drosophila melanogaster
Sequence 2:NP_001418340.1 Gene:Wdhd1 / 305827 RGDID:1310200 Length:1119 Species:Rattus norvegicus


Alignment Length:956 Identity:285/956 - (29%)
Similarity:453/956 - (47%) Gaps:122/956 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGT 65
            |..::..:||.||.|:|.:.:...|.||:|||:|||:|.|..:.||||:|..:||.....|....
  Rat     1 MPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNG 65

  Fly    66 RLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKVSGGYT--AAGSEDTTIKVLKGDTAGNET 128
            :|:.:...||:..|||||...||||.|||..|..:..:|..|  ||||.|..:||:.......:.
  Rat    66 KLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQ 130

  Fly   129 VLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFE 193
            ...||..|:|:|....:...|.|.:.||.::|||..:.....:...|.|.|...::.......::
  Rat   131 TFRGHDAPVLSLSFDPKDVFLASASCDGTVRVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQ 195

  Fly   194 PQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVK 258
            |::|:.||..|:..:.:.....|...|.|.|.||:...:...:||.|:.||||...|.:.:::|:
  Rat   196 PKTGKFLAVPVEKSVKLYRRETWSNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVE 260

  Fly   259 KRKAVTVEIPPSDCNAITCLAW----------NLSGEVEVA--FCDATGQLGT------------ 299
            .::.:. .:......||..|||          ::.|.:.:.  .||.:|:|.:            
  Rat   261 TKECME-RVKHEKGYAICGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYS 324

  Fly   300 -VFLGDAVDTGN-GDGLVDDQAEL----LGDDYEFEAGDDVDTAA-----DDGDGVSLEQLKRKV 353
             :|.||  ||.: ||.|.|:..|:    .|...|.:..||:..||     ||.:.|.:..|:..:
  Rat   325 DLFDGD--DTSSAGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDL 387

  Fly   354 MNFADPVDHDDASNQSLDSSSRTVPAPVAPQIKLF------KQQTAFQPSATPADLEHRYMAWND 412
                    |.:.......||..::|. |..|..|:      .:|..||||:||..|.||:||||.
  Rat   388 --------HREEGEDRQASSLHSLPL-VKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNS 443

  Fly   413 VGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALASNE----SSKLVVIA 473
            |||:..:.:.. ||:|||||||.|||||.|:||...:.:.|:|..|:.||...    :|||..:.
  Rat   444 VGIIRCYNDDQ-DSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLH 507

  Fly   474 LAA-AGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTIPGPMVAIAGHE 537
            .:: ..:|||.:.:|:.|..||:.......|.|||:..||:||:.|.|:||..:|||:|::|||.
  Rat   508 FSSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVVSMAGHG 572

  Fly   538 HSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYL---PVPLTPGRQLTWFGYSDTGSPSIADN 599
            ..|.:|||........|.|...|:.:.  ..:::.|   |:|||....|||.|:|..|:|...|:
  Rat   573 EQLCIVYHRGTGFDGDQCLGVQLLELG--RKKKQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDS 635

  Fly   600 MGLLQLYRRS-SNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPMTNPRPMLQE 663
            .|.:::..|. .|.|.|:|:..:.....|.:::||.:.|..|.::.:.|:|:.:|.|.|||.:..
  Rat   636 EGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAI 700

  Fly   664 LRMQIPLCDVEVEKSELEDALLRSSLMQ--MD---------------GAEKMQKETAIKLFALAC 711
            |..::|.|....||.::|:....|.|..  :|               .|.|.|:|..:|:.||:|
  Rat   701 LPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYDYEESIKKQAVKEQQELLMKMLALSC 765

  Fly   712 SSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCELLP---------QLEAVQEARKQ 767
            ..|.|.|..||.: :...:.:.||:|||::..::.|:.:|.||..         |.|..:|..::
  Rat   766 KLEREFRCVELAD-LMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAEIQTEEREEDFRE 829

  Fly   768 QTLLGASGIAATIVLPMTPTSASQSGPKPKAIELSSAKRGTL-------KRLVNSPNMFKAAAAS 825
            :...|.|         .|.|..||...:.:..|.:..:..|:       :..|...|:.::|.:|
  Rat   830 RLNAGYS---------HTTTEWSQPRVRSQVEEDAEDREDTVSEGNPEPQNHVIGQNLIQSANSS 885

  Fly   826 AASRPSTPDITPSPLDTQENIFGESESEV-PMGKATDHRSPLNSVN 870
                 .||.:....      :|..|:..| |.......:.|..|||
  Rat   886 -----DTPAMKSGA------VFSSSQGRVNPFKVLVSSKEPAVSVN 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ctf4NP_610921.1 WD40 12..256 CDD:475233 82/245 (33%)
WD40 repeat 16..52 CDD:293791 17/35 (49%)
WD40 repeat 97..131 CDD:293791 10/35 (29%)
WD40 repeat 138..173 CDD:293791 9/34 (26%)
WD40 repeat 181..223 CDD:293791 7/41 (17%)
WD40 repeat 231..268 CDD:293791 9/36 (25%)
Mcl1_mid 393..669 CDD:463539 106/284 (37%)
Wdhd1NP_001418340.1 WD40 10..289 CDD:238121 89/279 (32%)
WD40 repeat 21..54 CDD:293791 16/32 (50%)
WD40 repeat 59..92 CDD:293791 13/32 (41%)
WD40 repeat 97..133 CDD:293791 10/35 (29%)
WD40 repeat 140..175 CDD:293791 9/34 (26%)
WD40 repeat 184..225 CDD:293791 7/40 (18%)
WD40 repeat 233..269 CDD:293791 9/36 (25%)
WD40 repeat 276..299 CDD:293791 5/22 (23%)
Mcl1_mid 423..706 CDD:463539 106/285 (37%)
HMG-box_WDHD1 1004..1066 CDD:438809
Blue background indicates that the domain is not in the aligned region.

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