DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctf4 and mcl1

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_594128.1	Gene:	mcl1 / 2543387	PomBaseID:	SPAPB1E7.02c	Length:	815	Species:	Schizosaccharomyces pombe

Alignment Length:	854	Identity:	200/854 - (23%)
Similarity:	346/854 - (40%)	Gaps:	157/854 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRS----------SCLGEFVMCIAHT 63
            |||||:|.|.|.||..|:|::|.|::..||.:...||::|.|          ..:.|...|
pombe     9 RYAHTDGLTRLAYTRDGKFLLTVGSNQVIRKFQVGSDEEPDSIDNHQDPITGIAVAENYFC---- 69

  Fly    64 GTRLLASTDRNTIHAYTFPEMDSDGILMRFTAPA--TCLKVSGGYTAAGSEDTTIKV-------- 118
                 ..::..|:..|.........:|.|.|.|.  ....|.|.:.|..|::|.:||
pombe    70 -----TCSEDATVCVYPIDSPTEHTLLARTTLPIRDVAYSVDGNWIAIASDETAVKVVSSTDSSQ 129

  Fly   119 ---LKGDTAGNETVLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNS 180
               |:...|.|:.|.....|..||:.           :.:|.|..::.:..:.:|.:..  .:.|
pombe   130 IFSLRPAKASNKHVTYSPNGNFLAVS-----------SCNGILYFYDTQTRELIKFLTN--TIAS 181

  Fly   181 FESAS-LYGTPHFEPQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLA 244
            .|:.| :.....:.|::|.....:.|:.:.|::..:|...:||......|..:...:|.||..:|
pombe   182 LEAESEICSKAAWHPKNGTFAVASTDHFVSVISPDDWLPLYKLLPKENHSGVTDISWSSNGMYIA 246

  Fly   245 AGTTKGEVSIFDVKKRKAVTVEIPPSDCNAITCLAWNLSGEVEVAFCDATG-------------- 295
            |...||.:.|:|.:..: |.||:|.|   .:..|||.....| ::|....|
pombe   247 ASFKKGGILIWDTQSHE-VVVELPYS---TVVALAWQPFENV-LSFTTNQGILYSCPDVIPKSIL 306

  Fly   296 ---------------------QLGTVFLGDAVDTGNGDGLVDDQAELLGDDYEFEAGDDVDTAAD 339
                                 :|..:|..|...:.|.:.|..:.|   .::.||...|.:|::.|
pombe   307 KEENDPTKPLTSSKSKNRTSKELDDLFGSDDEQSQNVNDLDGNSA---NEENEFINHDGLDSSLD 368

  Fly   340 -DGDGVSLEQ------LKRKVMNFAD---PVDHDDASNQSLDSSSRTVPAPVAPQIKLFKQQTAF 394
             |||...:::      .|||.....|   .:::..:..:.|.:|   :..||
pombe   369 LDGDSYMVDENDLNLAKKRKQKALIDRTTTIENGSSKRRLLQAS---IHKPV------------- 417

  Fly   395 QPSATPADLEHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVS-SGA 458
            ...:||.....||:..|.||.:....:.:..::|.|||||.:.|...|..:..:..:|.:. .||
pombe   418 HTGSTPWQGNRRYLCLNLVGFIWTVQQDAEHNTITVEFHDETTHRKYHFVDDQKFEMACLDHEGA 482

  Fly   459 L-ALASNESSKLVVIALAA---AGNKEWSLSLP-DCESAEAVVATRFLVAVATSSSFLRIFTVMG 518
            | |..:.|||..|:...|.   :...||:::|| :.||...:..:..:|.|.||:.::|:|:..|
pombe   483 LYASPATESSPGVIYYKAHVDWSRKSEWAMALPMENESPVTISLSSSVVLVCTSAGYVRVFSRQG 547

  Fly   519 TQREVLTIPG-PMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYLPVPLTPGRQ 582
            ....:..... |.||.:..:.:::.:.:....|.....|...:.:|:...:.|....|.|.|...
pombe   548 FPISIHRSKHLPFVACSSFQDTIITIANDGLSSDGNSRLVYSIEDISRDEMLQTGDGVALPPQGT 612

  Fly   583 LTWFGYSDTGSPSIADNMGLLQL---YRRSSNA-WFPICDT--MKQSTSVSHNFFVVAVSEKRQI 641
            |....:||.|.|.|.|:.|:|.:   :|....| |.|:.||  :::..|...:::.|.|::.:
pombe   613 LESVFFSDVGDPYIYDSTGVLLVLMHWRIPGQAKWIPVLDTNELERRKSRQESYWPVTVADNQ-- 675

  Fly   642 VQAVLCRGTS-YPMTNPRPMLQELRMQIPLC-----DVEVEKSELEDALLRSSLMQM-------D 693
            ...:|.:|.| ||.. ||||..|...:|| |     |.......||:..||:.|...       |
pombe   676 FHCILLKGASRYPYF-PRPMFTEFDFRIP-CNTNNPDASTSVPVLEELQLRNKLFLTLLEDSIGD 738

  Fly   694 G----AEKMQ--------KETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIH 746
            |    .||:.        .:..::|...||..|...|..||.:::..|..:..|.|.|......:
pombe   739 GDVTEDEKISIARLEANIDKALLQLIQKACLEERIERVYELTKTLRRTTSIAAAQKIALHHSLTN 803

  Fly   747 LSDRLCELL 755
            :::::..||
pombe   804 VAEKIGNLL 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	78/353 (22%)
		WD40	12..256	CDD:295369	61/267 (23%)
		WD40 repeat	16..52	CDD:293791	14/45 (31%)
		WD40 repeat	97..131	CDD:293791	11/46 (24%)
		WD40 repeat	138..173	CDD:293791	5/34 (15%)
		WD40 repeat	181..223	CDD:293791	8/42 (19%)
		WD40 repeat	231..268	CDD:293791	12/36 (33%)
		Mcl1_mid	393..670	CDD:289138	77/290 (27%)
mcl1	NP_594128.1	WD40	<11..269	CDD:225201	66/280 (24%)
		WD40	12..285	CDD:295369	71/299 (24%)
		WD40 repeat	16..53	CDD:293791	14/36 (39%)
		WD40 repeat	59..93	CDD:293791	5/42 (12%)
		WD40 repeat	98..132	CDD:293791	7/33 (21%)
		WD40 repeat	141..176	CDD:293791	7/45 (16%)
		WD40 repeat	188..225	CDD:293791	6/36 (17%)
		WD40 repeat	233..275	CDD:293791	14/45 (31%)
		Mcl1_mid	416..704	CDD:289138	80/304 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2182
eggNOG	1	0.900	-	-		E1_KOG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I1352
OMA	1	1.010	-	-		QHG55477
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	1	1.000	-	-		oto101885
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R690
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900