DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctf4 and Wdhd1

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_001347461.1	Gene:	Wdhd1 / 218973	MGIID:	2443514	Length:	1118	Species:	Mus musculus

Alignment Length:	982	Identity:	285/982 - (29%)
Similarity:	453/982 - (46%)	Gaps:	153/982 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGT 65
            |...:..:||.||.|:|.:.:...|.:|:|||:|||:|.|..:.||||:|..:||.....|....
Mouse     1 MPATQKPMRYGHTEGHTEVCFDDSGSYIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNG 65

  Fly    66 RLLASTDRNTIHAYTFPEMDSDGILMRFTAPA--TCLKVSGGYTAAGSEDTTIKVLKGDTAGNET 128
            :|:.:...||:..|||||...||||.|||..|  .....:|...||||.|..:||:.......:.
Mouse    66 KLVTAVSNNTVQVYTFPEGVPDGILTRFTTNANHVVFNGAGNKIAAGSSDFLVKVVDVMDNSQQQ 130

  Fly   129 VLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFE 193
            ...||..|:|:|....:...|.|.:.||.::|||..:.....:...|.|.|...:|.......::
Mouse   131 TFRGHDAPVLSLSFDPKDIFLASASCDGTVRVWNISDQTCAVSWPVLQKSNDVVNAKSICRLAWQ 195

  Fly   194 PQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVK 258
            |::|:|||..|:..:.:.....|...|.|.|.|:|...:...:||.|:.||||...|.:.:::|:
Mouse   196 PKAGKLLAVPVEKSVKLYRRETWSNPFDLSDSSISQTLNIVTWSPCGQYLAAGAINGLIVVWNVE 260

  Fly   259 KRKAVTVEIPPSDC---------NAITCLAW----------NLSGEVEVA--FCDATGQLGT--- 299
            .:          ||         .||..|||          ::.|.:.|.  .||.:|::.:
Mouse   261 TK----------DCMERVKHEKGYAICGLAWHPTCSRICYTDVEGNLGVLENVCDLSGKVSSNKV 315

  Fly   300 ----------VFLGDAVDTGN-GDGLVDDQAEL----LGDDYEFEAGDDVDTAA-----DDGDGV 344
                      :|.||  ||.: ||.|.|:..|:    .|...|.:..||:..||     ||.:.|
Mouse   316 SSRVEKDYNDLFDGD--DTSSAGDFLNDNAVEIPSFSKGIINEDDDNDDIMLAADHDLGDDENSV 378

  Fly   345 SLEQLKRKVMNFADPVDHDDASNQSLDSSSRTVPAPVAPQIKLF------KQQTAFQPSATPADL 403
            .:..||      || :.|.:..:.....|...:|. :.||...:      .:|..||.|:||..|
Mouse   379 DVTMLK------AD-LSHKEEGDDDQARSIHNLPL-IRPQRPFYDGPMPTPRQKPFQSSSTPLHL 435

  Fly   404 EHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALASNE--- 465
            .||:|.||.|||:..:.:.. ||:|||||||.|||||.|:.|...:.:.::|..|:.||...
Mouse   436 SHRFMVWNSVGIIRCYNDDQ-DSAIDVEFHDTSIHHATHLLNAFNYTMGTLSHEAILLACESADE 499

  Fly   466 -SSKLVVIALAA-AGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTIPG 528
             :|||..:..:: ..:|||.:.:|..|..||:.......|.||::..||:||:.|.|:||..:||
Mouse   500 LASKLHCLHFSSWDSSKEWMVDMPQNEDIEAICLGLGWAAAATTALLLRLFTIGGVQKEVFCLPG 564

  Fly   529 PMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYL---PVPLTPGRQLTWFGYSD 590
            |:|::|||...|.:|||........|.|...|:.:.  ..:.:.|   |:|||....|||.|:|.
Mouse   565 PVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELG--RKKNQVLHGDPLPLTRKSYLTWLGFSA 627

  Fly   591 TGSPSIADNMGLLQLYRRS-SNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPM 654
            .|:|...|:.|.:::..|. .|.|.|:|:..:.....|.:::||.:.|..|.::.:.|:|:.:|.
Mouse   628 EGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPP 692

  Fly   655 TNPRPMLQELRMQIPLCDVEVEKSELEDALLRSSLMQ-----------------MDGAEKMQKET 702
            |.|||.:..|..::|.|....||.::|:....|.|..                 .:.|.|.|:|.
Mouse   693 TLPRPAVAILSFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQEL 757

  Fly   703 AIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCELLPQ-----LEAVQ 762
            .:|:.||:|..|.|.|..||.: :...:.:.||:|||::..::.|:.:|.||..:     .|...
Mouse   758 LMKMLALSCKLEREFRCVELAD-LMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAETQS 821

  Fly   763 EARKQQTL---LGASGIAATIVLPMTPTSASQSGPKPKA-IELSSAKRGTLKRLVNSP------- 816
            |..|::..   |.|.         .:.|:...|.|:.:: :|.:..:..|:..  ..|
Mouse   822 EEEKEEDFREKLNAG---------YSHTTTEWSRPRVRSQVEDAEDREDTVSE--EKPESHNHGQ 875

  Fly   817 NMFKAAAASAASRPSTPDITPSPLDTQENIFGESE-----------SEVPMGKATDHRSP--LNS 868
            |:|::|.:|     .||.:....      :|..|:           |:.|...|...||.  |:|
Mouse   876 NLFQSANSS-----DTPALKSGA------VFSSSQGWVNPFKVVVSSKEPAVSANSTRSANILDS 929

  Fly   869 VNPFAMK 875
            :|..:.|
Mouse   930 MNKSSRK 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	99/338 (29%)
		WD40	12..256	CDD:295369	82/245 (33%)
		WD40 repeat	16..52	CDD:293791	16/35 (46%)
		WD40 repeat	97..131	CDD:293791	9/35 (26%)
		WD40 repeat	138..173	CDD:293791	9/34 (26%)
		WD40 repeat	181..223	CDD:293791	9/41 (22%)
		WD40 repeat	231..268	CDD:293791	9/36 (25%)
		Mcl1_mid	393..670	CDD:289138	101/285 (35%)
Wdhd1	NP_001347461.1	WD40	10..289	CDD:238121	91/288 (32%)
		WD 1	11..50		18/38 (47%)
		WD40 repeat	21..54	CDD:293791	15/32 (47%)
		WD 2	52..91		14/38 (37%)
		WD40 repeat	59..92	CDD:293791	13/32 (41%)
		WD 3	93..131		11/37 (30%)
		WD40 repeat	97..133	CDD:293791	9/35 (26%)
		WD 4	134..173		12/38 (32%)
		WD40 repeat	140..175	CDD:293791	9/34 (26%)
		WD 5	184..223		8/38 (21%)
		WD40 repeat	189..225	CDD:293791	8/35 (23%)
		WD 6	228..267		13/48 (27%)
		WD40 repeat	233..269	CDD:293791	11/45 (24%)
		WD 7	271..310		10/38 (26%)
		WD40 repeat	276..299	CDD:293791	5/22 (23%)
		Mcl1_mid	425..707	CDD:315095	101/284 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..885		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1005		9/26 (35%)
		NHP6B	949..>1061	CDD:227935
		HMG	1006..1063	CDD:197700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1054..1074
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848663
Domainoid	1	1.000	188	1.000	Domainoid score	I3324
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56019
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2072
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55477
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	1	1.000	-	-		oto94804
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R690
SonicParanoid	1	1.000	-	-		X4720
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930