DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctf4 and WDHD1

DIOPT Version :9

Sequence 1:	NP_610921.1	Gene:	Ctf4 / 36551	FlyBaseID:	FBgn0033890	Length:	895	Species:	Drosophila melanogaster
Sequence 2:	NP_009017.1	Gene:	WDHD1 / 11169	HGNCID:	23170	Length:	1129	Species:	Homo sapiens

Alignment Length:	1006	Identity:	288/1006 - (28%)
Similarity:	461/1006 - (45%)	Gaps:	166/1006 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGT 65
            |...|..:||.||.|:|.:.:...|.||:|||:|||:|.|..:.||||:...:||.....|....
Human     1 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSG 65

  Fly    66 RLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKVSGGYT--AAGSEDTTIKVLKGDTAGNET 128
            :|:.:...|||..:||||...||||.|||..|..:..:|..|  ||||.|..:|::....:..:.
Human    66 KLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQK 130

  Fly   129 VLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFE 193
            ...||..|:|:|....:...|.|.:.||.::||...:.....:...|.|.|...:|.......::
Human   131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQ 195

  Fly   194 PQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVK 258
            |:||:|||..|:..:.:....:|...|.|.|:.:|...:...:||.|:.||||:..|.:.:::|:
Human   196 PKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVE 260

  Fly   259 KRKAVTVEIPPSDC---------NAITCLAWN-LSGEVEVAFCDATGQLG--------------- 298
            .:          ||         .||..|||: ..|  .:::.||.|.||
Human   261 TK----------DCMERVKHEKGYAICGLAWHPTCG--RISYTDAEGNLGLLENVCDPSGKTSSS 313

  Fly   299 -----------TVFLGDAVDTGN-GDGLVDDQAE-------LLGDDYEFEAGDDVDTAA------ 338
                       .:|.||  |..| ||.|.|:..|       ::.||   |..:|:..|:
Human   314 KVSSRVEKDYNDLFDGD--DMSNAGDFLNDNAVEIPSFSKGIINDD---EDDEDLMMASGRPRQR 373

  Fly   339 -----DDGDGVSLEQLKR-KVMNFADPVDHDDAS--NQSLDSSSR-----TVPAPVAPQIKLFKQ 390
                 ||.:.|.:..||. ..:...:..|..:.|  |..|.:|.|     .:|.|         :
Human   374 SHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTP---------R 429

  Fly   391 QTAFQPSATPADLEHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVS 455
            |..||..:||..|.||:|.||.:||:..:.:.. |::|||||||.|||||.|:||...:.:|.:|
Human   430 QKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQ-DNAIDVEFHDTSIHHATHLSNTLNYTIADLS 493

  Fly   456 SGALALASNE----SSKLVVIALAA-AGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFT 515
            ..|:.||...    :|||..:..:: ..:|||.:.||..|..||:...:...|.|||:..||:||
Human   494 HEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFT 558

  Fly   516 VMGTQREVLTIPGPMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYL---PVPL 577
            :.|.|:||.::.||:|::|||...|.:|||........|.|...|:.:.  ..:::.|   |:||
Human   559 IGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELG--KKKKQILHGDPLPL 621

  Fly   578 TPGRQLTWFGYSDTGSPSIADNMGLLQLYRRS-SNAWFPICDTMKQSTSVSHNFFVVAVSEKRQI 641
            |....|.|.|:|..|:|...|:.|::::..|. .|.|.|||:|.:.....|.:::||.:.|..|.
Human   622 TRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQ 686

  Fly   642 VQAVLCRGTSYPMTNPRPMLQELRMQIPLCDVEVEKSELEDALLRSSLMQ--------------- 691
            ::.:.|:|:.:|.|.|||.:..|..::|.|.:..||.::|:...||.:..
Human   687 LRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEE 751

  Fly   692 --MDGAEKMQKETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCEL 754
              .:.|.|.|:|..:|:.||:|..|.|.|..||.: :...:.:.||:|||::..::.|:.:|.||
Human   752 STKNQATKEQQELLMKMLALSCKLEREFRCVELAD-LMTQNAVNLAIKYASRSRKLILAQKLSEL 815

  Fly   755 LPQLEA------VQEARKQQTL-----LGASGIAATIVLP----MTPTSASQSG-----PKPKAI 799
            ..:..|      |:|..:::..     .|.|..|.....|    .....|..||     .||
Human   816 AVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKP--- 877

  Fly   800 ELSSAKRGTLKRLVNSP-----------------NMFKAAAASAASRPSTPDITPSPLDTQENIF 847
            |:....:.:..:..||.                 |.||.:|:|  ..|:....:....:..:|:.
Human   878 EIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASS--KEPAMSMNSARSTNILDNMG 940

  Fly   848 GESESEVPMGKATDH-RSPLNSVNPFAMKRK 877
            ..|:....:.:.|:: :||:  :.|...|.|
Human   941 KSSKKSTALSRTTNNEKSPI--IKPLIPKPK 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctf4	NP_610921.1	WD40	1..>304	CDD:225201	100/340 (29%)
		WD40	12..256	CDD:295369	81/245 (33%)
		WD40 repeat	16..52	CDD:293791	16/35 (46%)
		WD40 repeat	97..131	CDD:293791	9/35 (26%)
		WD40 repeat	138..173	CDD:293791	8/34 (24%)
		WD40 repeat	181..223	CDD:293791	10/41 (24%)
		WD40 repeat	231..268	CDD:293791	9/36 (25%)
		Mcl1_mid	393..670	CDD:289138	102/285 (36%)
WDHD1	NP_009017.1	WD40	10..288	CDD:238121	91/289 (31%)
		WD40	<11..299	CDD:225201	94/299 (31%)
		WD 1	11..50		19/38 (50%)
		WD40 repeat	21..54	CDD:293791	15/32 (47%)
		WD 2	52..91		14/38 (37%)
		WD40 repeat	59..92	CDD:293791	13/32 (41%)
		WD 3	92..131		12/38 (32%)
		WD40 repeat	97..133	CDD:293791	9/35 (26%)
		WD 4	134..173		11/38 (29%)
		WD40 repeat	140..182	CDD:293791	10/41 (24%)
		WD 5	184..223		9/38 (24%)
		WD40 repeat	189..225	CDD:293791	9/35 (26%)
		WD 6	228..267		12/48 (25%)
		WD40 repeat	233..269	CDD:293791	11/45 (24%)
		WD 7	271..310		11/40 (28%)
		Mcl1_mid	432..714	CDD:289138	102/284 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..897		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..1017		11/58 (19%)
		HMG	1017..1074	CDD:197700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158265
Domainoid	1	1.000	192	1.000	Domainoid score	I3235
eggNOG	1	0.900	-	-		E1_KOG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56019
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2134
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55477
OrthoDB	1	1.010	-	-		D155530at2759
OrthoFinder	1	1.000	-	-		FOG0005096
OrthoInspector	1	1.000	-	-		oto91224
orthoMCL	1	0.900	-	-		OOG6_102719
Panther	1	1.100	-	-	LDO	PTHR19932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R690
SonicParanoid	1	1.000	-	-		X4720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800