Protein Alignment CG6701 and HELZ

DIOPT Version :9

• Sequence 1: NP_001188923.1
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_006722277.1
• Gene: HELZ / 9931
• HGNCID: 16878
• Length: 1970
• Species: Homo sapiens
• Alignment Length: 1474
• Identity: 306/1474 - (20%)
• Similarity: 532/1474 - (36%)
• Gaps: 411/1474 - (27%)

  Fly    80 KAKMRKLFEVHLNALPNSSEIRQKLSSQGATNIGSLLHRTNFLINTPRGNPNYRIKNFSLMDFRK 144
            |.|::.:..:...:|  :.|....:.::..|.:.:||..|    .|...|   .:..:.:.|..:
Human   105 KGKLQPVSTILAKSL--TGESLNGMVTKDLTRLKTLLSET----ETATSN---ALSGYHVEDLDE 160

  Fly   145 EKFNLLDEQHRLRGIASTTDVPGGAPAEGNKPIIEEYKL-----------------DTDVKPTLL 192
            ...|....:...|||.|:                |||.|                 ....:..|.
Human   161 GSCNGWHFRPPPRGITSS----------------EEYTLCKRFLEQGICRYGAQCTSAHSQEELA 209

  Fly   193 KFQKRL------LLQSDKDFELQSLGCY----------------ICQENFEKIEKYEEHVEYHGD 235
            ::|||.      |.|.:::.:|.  |.|                :..|..|.::     ||::.|
Human   210 EWQKRYASRLIKLKQQNENKQLS--GSYMETLIEKWMNSLSPEKVLSECIEGVK-----VEHNPD 267

  Fly   236 ESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGFTLK----TFRKDLVVD----KFIIV------- 285
            .|...|.||           |:||..    |..|.|    .:|..|:.|    .|.|:
Human   268 LSVTVSTKK-----------SHQTWT----FALTCKPARMLYRVALLYDAHRPHFSIIAISAGDS 317

  Fly   286 --QLRQFYYVYGAQMP----------LPVNGSGELVFFV----DSHVFMILREQPIVIGFTIQGE 334
              |:.|       ::|          :..||....|:.|    ::.:|...| |.||..|.::..
Human   318 TTQVSQ-------EVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFR-QTIVFDFGLEPV 374

  Fly   335 KYVEQHHFMRTEALPKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASFDNQ 399
                   .|:...:..||.....|.:.:|:..             |.:|.:.:.:...:..|:..
Human   375 -------LMQRVMIDAASTEDLEYLMHAKQQL-------------VTTAKRWDSSSKTIIDFEPN 419

  Fly   400 YQNYCERG---------------------REITQENLTGTLRTLLQVEDIERLQHYLSLKQSEME 443
            .....|:.                     :.:|:.|....|..||.:|:|.:   |..:..:.
Human   420 ETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQ---YKEISNTS-- 479

  Fly   444 LHQFGRELSVKMQMGTT-------------SMSVE-DILSPGDDVLIINEKGNPKSAVRKMLENN 494
                |...|..:...||             ::.|: .||:   ..::....|..|.|....|...
Human   480 ----GASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILA---SFMLTGVSGGAKYAQNGQLFGR 537

  Fly   495 NNVLE----------LALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQ----RVNITC 545
            ..:.|          |.:...:::.........:|.:...:.:||.|.|...:.:    |::..|
Human   538 FKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSREC 602

  Fly   546 ERQL---PD-NTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPG-----EIPNTPLASG 601
            ..:|   || :|...|.|:..|..:...:.||.::.      ...:|||.     .||.:|....
Human   603 CEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIK------DNGVLFPDISMTPTIPWSPNRQW 661

  Fly   602 VLQLNNKLISTNPEQMQAVRQIALSPRLK-APYIVFGPPGTGKTSTIVEAIYQLYINRPETHILV 665
            ..||:.:|   |.:|.:||..|.....:: .|.::.||.|||||.|:.:|:..:...:..:.||:
Human   662 DEQLDPRL---NAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILI 723

  Fly   666 LAGSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEY---SNMYTVHFYP 727
            ...||:|.|......|....:|...|.||| |::..|  |.:..:..::.:|   |:.::....|
Human   724 CTHSNSAADLYIKDYLHPYVEAGNPQARPL-RVYFRN--RWVKTVHPVVHQYCLISSAHSTFQMP 785

  Fly   728 AVQAVHQYRIVICTLSLAGKLS----TGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLN 788
            ..:.:.::|:|:.||:.:..|.    ..||     :||:.:||||.:.|.|.:|.:......| .
Human   786 QKEDILKHRVVVVTLNTSQYLCQLDLEPGF-----FTHILLDEAAQAMECETIMPLALATQNT-R 844

  Fly   789 LILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLI--RNFRSHPE 851
            ::|:|||.||.|.:.|:.|.|..|.::|.:||.:.          |.|....|::  .|:|||..
Human   845 IVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEH----------YPAEFPCRILLCENYRSHEA 899

  Fly   852 IVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDV 916
            |::..:.::|||.|........    |..||      |:.|.:..|..:..|:|.:..||.|:..
Human   900 IINYTSELFYEGKLMASGKQPA----HKDFY------PLTFFTARGEDVQEKNSTAFYNNAEVFE 954

  Fly   917 VMDYVKDL-----MYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKE 976
            |::.|::|     :.:|    ||....||:::||.:|..||:.:|..:..|.::...|...|||:
Human   955 VVERVEELRRKWPVAWG----KLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQ 1015

  Fly   977 KHVIIVSFVRS-------FTP---------------KLGFLNNERRLNVLLSRPISLLILIGNPR 1019
            ..|:.:|.||:       .||               ..|||:|.:.||..::|..||:.::|:|.
Human  1016 FRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPI 1080

  Fly  1020 TLSQ----NSDFQHIIEMCRNRKTLVGEQYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLK 1080
            .|..    ...::..|.:|....:|.|..:                       :|..:.|.....
Human  1081 ALCSIGRCRKFWERFIALCHENSSLHGITF-----------------------EQIKAQLEALEL 1122

  Fly  1081 RKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPKVPRSVDHDLDEVRSIEAQLKD 1145
            :|.:..||:  |..|..:  .|.|.:.....|.:      :.|...:|:.|         .|...
Human  1123 KKTYVLNPL--APEFIPR--ALRLQHSGSTNKQQ------QSPPKGKSLHH---------TQNDH 1168

  Fly  1146 FQLETKQDA---AGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALH------SSSVSRPAIRKP 1201
            ||    .|.   ...|:|:.|........|.:.|...|.|..:|...      :|.:..||:...
Human  1169 FQ----NDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGG 1229

  Fly  1202 TVSAATPVAKSRSPMPEI---------PSSSKHPISMSSNPLSTNTERCVNGVLCGIEAVPP--- 1254
            .|..:.|:     |:|..         |....|..:|:.|.....|....:.:..|:...||
Human  1230 NVVMSVPL-----PVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTI 1289

  Fly  1255 -------------SENKTTRSSAYNHIPSGN-FRFENVRPT-PEEV------------------- 1285
                         .:|:..:|...|..|..| .|....:|| |::|
Human  1290 GQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVY 1354

  Fly  1286 -----RRFNGANDQRRARPFREPHGNWS--NFGWSPPPRDPTPP 1322
                 .|.:..|.:....|...||..::  |..:.|.|:.|.||
Human  1355 PSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPP 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	167/690 (24%)
		AAA_19	618..687	CDD:289986	20/69 (29%)
		AAA_12	812..1019	CDD:289832	62/235 (26%)
HELZ	XP_006722277.1	zf-CCCH	181..205	CDD:279036	2/23 (9%)
		AAA_11	669..861	CDD:289831	58/203 (29%)
		P-loop_NTPase	669..>766	CDD:304359	31/102 (30%)
		DNA2	<785..1099	CDD:224037	93/343 (27%)
		UvrD_C_2	868..1079	CDD:304668	62/234 (26%)
		PHA03160	<1656..1815	CDD:165431

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820