DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and DNA2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_012034.1	Gene:	DNA2 / 856569	SGDID:	S000001207	Length:	1522	Species:	Saccharomyces cerevisiae

Alignment Length:	1152	Identity:	227/1152 - (19%)
Similarity:	423/1152 - (36%)	Gaps:	339/1152 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ATNIGS---LLHRT--NFLINTPRGNPNY-----RIKNFSLMDFRKEKFNLLDEQHRLRGIASTT 163
            ||::||   .|.|:  ......|||.|:.     .|.:..|.|  ..|:.|...:..:..|....
Yeast   510 ATSVGSSVGCLRRSILQMQFQDPRGEPSLVMTLGNIVHELLQD--SIKYKLSHNKISMEIIIQKL 572

  Fly   164 DVPGGAPAEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQS---------DKDFELQSLGCYICQE- 218
            |           .::|.|.....:....:::.|.|:::.         :|.....:.|||....
Yeast   573 D-----------SLLETYSFSIIICNEEIQYVKELVMKEHAENILYFVNKFVSKSNYGCYTSISG 626

  Fly   219 -------NFEKIEKYEEHV--EYHG-----DESDFQSLKKMKKYPTPIV-------SLSYQT--- 259
                   :...:...||::  ..:|     |.:...:::..||:..|:.       |:||:.
Yeast   627 TRRTQPISISNVIDIEENIWSPIYGLKGFLDATVEANVENNKKHIVPLEVKTGKSRSVSYEVQGL 691

  Fly   260 ----CVDSHY---FGFTLKTFRKDLVVDKF--IIVQLR---------------QFYYVYG-AQM- 298
                .::..|   ..|.|..|.:|..:.||  ::..::               |...|:| ||.
Yeast   692 IYTLLLNDRYEIPIEFFLLYFTRDKNMTKFPSVLHSIKHILMSRNRMSMNFKHQLQEVFGQAQSR 756

  Fly   299 ----PLPVNGSGELVFFVDSHVFMILRE-----QPIVIGFTIQGEKYVEQHHFMRTEALPKASFN 354
                ||..:.|.:..|..:|  .|:|.:     .|...|. ::||..:..:|.         |.|
Yeast   757 FELPPLLRDSSCDSCFIKES--CMVLNKLLEDGTPEESGL-VEGEFEILTNHL---------SQN 809

  Fly   355 INPYRLSSKETF-KSKGLPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREI------TQ 412
            :..|    ||.| |...|           ..|.|.:..|:             .:|:      |:
Yeast   810 LANY----KEFFTKYNDL-----------ITKEESSITCV-------------NKELFLLDGSTR 846

  Fly   413 ENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLII 477
            |:.:|...:.|.|.::  ::|.   |.....::.|.|..:........|..:    :..|.|:|.
Yeast   847 ESRSGRCLSGLVVSEV--VEHE---KTEGAYIYCFSRRRNDNNSQSMLSSQI----AANDFVIIS 902

  Fly   478 NEKG------------NPK----SAVRKMLENN-----------NNVLELALKDFDSILRWARNV 515
            :|:|            ||.    |..||:|.|.           .:|:|..|:. .|::.....|
Yeast   903 DEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLLDKEKGVTTIQSVVESELEQ-SSLIATQNLV 966

  Fly   516 DGMVGSLDKQPRVYFAR------ILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQ 574
            ...:...|.|..:..||      .|...:..|:|..||.                         :
Yeast   967 TYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDIVDERS-------------------------K 1006

  Fly   575 QLSFTRHSD-----VQRILFPGEIP------NTPLASGVLQLNNKLISTNPEQMQAVRQIALSPR 628
            ....|:.||     ::.:|.....|      :.|:....|..:..|   |..|.:|:.::.   |
Yeast  1007 LCRKTKRSDGGNEILRSLLVDNRAPKFRDANDDPVIPYKLSKDTTL---NLNQKEAIDKVM---R 1065

  Fly   629 LKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPR 693
            .:...::.|.||||||:.|.| |.::.::..: .:|:.:.:::|.|.:.::|
Yeast  1066 AEDYALILGMPGTGKTTVIAE-IIKILVSEGK-RVLLTSYTHSAVDNILIKL------------- 1115

  Fly   694 PLTRIFSANCDRRIDNIDDLLLEYSNMYTVH-----FYPAVQAVHQYRIVICTLSLAGKLSTGGF 753
                        |..||.  ::.....:.||     :.|...:|..|...:..::....::|...
Yeast  1116 ------------RNTNIS--IMRLGMKHKVHPDTQKYVPNYASVKSYNDYLSKINSTSVVATTCL 1166

  Fly   754 AANNV--------YTHVFVDEAAASTEAEVLMGITCTLSPTL---NLILSGDHKQLGPVLQSQRA 807
            ..|::        :.:|.:|||     :::.|.:  .|.|..   ..|:.|||.||.|::::..|
Yeast  1167 GINDILFTLNEKDFDYVILDEA-----SQISMPV--ALGPLRYGNRFIMVGDHYQLPPLVKNDAA 1224

  Fly   808 NEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLR------ 866
            ...||..:||:...::....|.|           |...:|...:||:|.|.:.|:..|:
Yeast  1225 RLGGLEESLFKTFCEKHPESVAE-----------LTLQYRMCGDIVTLSNFLIYDNKLKCGNNEV 1278

  Fly   867 ----TEAPM-EIVCRFHN-------WFY-LPNATFPIMF--HSVFGTTMNTKSSVSLCNNKEIDV 916
                .|.|| |.:.|:.|       |.. :...|..::|  :......:......::.|:.|.::
Yeast  1279 FAQSLELPMPEALSRYRNESANSKQWLEDILEPTRKVVFLNYDNCPDIIEQSEKDNITNHGEAEL 1343

  Fly   917 VMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVII 981
            .:..|:.::..|:..|     |||:::.|:.|.:.:::..|...:..::..:.:.|||::|..||
Yeast  1344 TLQCVEGMLLSGVPCE-----DIGVMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDKKCII 1403

  Fly   982 VSFVRSFTPKLG--FLNNERRLNVLLSRPISLLILIGNPRTLS---QNSDFQHIIE-------MC 1034
            :|.||..:...|  .|...||:||.::|..|.||:||:..|:.   :...|.:::|       ||
Yeast  1404 ISMVRRNSQLNGGALLKELRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVNLLEERNWVYTMC 1468

  Fly  1035 R---------NRKTLVGEQYLNEDFITNKKTGANNV-NKGGAAGDQP 1071
            :         :|...:.|....    ..|:|||..: :|.....|:|
Yeast  1469 KDALYKYKFPDRSNAIDEARKG----CGKRTGAKPITSKSKFVSDKP 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	143/714 (20%)
		AAA_19	618..687	CDD:289986	16/68 (24%)
		AAA_12	812..1019	CDD:289832	54/229 (24%)
DNA2	NP_012034.1	DNA2	551..1481	CDD:224037	206/1075 (19%)
DNA2	NP_012034.1	DEXXQc_DNA2	1052..1253	CDD:350799	51/253 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810