DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and HELZ2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_024307774.1	Gene:	HELZ2 / 85441	HGNCID:	30021	Length:	2677	Species:	Homo sapiens

Alignment Length:	997	Identity:	222/997 - (22%)
Similarity:	371/997 - (37%)	Gaps:	272/997 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 SHVFMILREQPIVIGFTIQGEKYVEQHHFMRTEALPKASFN-----INPYRLSSK-ETFKSKGLP 372
            |..|.:..|:|::              |....:..|.|.|:     :.|.||.:: |.|:   :|
Human   182 SWTFAVHSEEPLL--------------HVALLKQEPGADFSLVAPGLPPGRLYARGERFR---VP 229

  Fly   373 PANPPIQVLSALKHEDAQMCLASFDNQYQ----NYCER-------GREITQENLTGTLRTLL--Q 424
            .:....||       ..::..|||....|    ::..|       |.::.|....|..|.|.  .
Human   230 SSTADFQV-------GVRVQAASFGTFEQWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGH 287

  Fly   425 VEDIERL----QHYL-----SLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGD-----DVL 475
            .|::||.    :|.:     :.:|:.:.....|..|:::....:.:...   :||.:     ...
Human   288 PEEMERWHTGNRHVVPGVERTAEQTALMAKYKGPALALEFNRSSVASGP---ISPTNYRQRMHQF 349

  Fly   476 IINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARI------- 533
            :..|:...:..|.|:.......|:.||:            ...:..|...|...:|.:
Human   350 LYEEEAAQQQLVAKLTLRGQVFLKTALQ------------TPALNMLFAPPGALYAEVPVPSSLM 402

  Fly   534 --------LG--VSTQRV-----------NITCERQ----------LPDNTTYTLIFRP-LRAVM 566
                    ||  |||..|           .:..||:          ||......|..:| .|.|:
Human   403 PDTDQGFLLGRAVSTALVAPVPAPDNTVFEVRLERRASSEQALWLLLPARCCLALGLQPEARLVL 467

  Fly   567 RYQYRALQQLSFTR-HSDV-----QRILFPGEIPN---------TPLASGVLQLNNKLISTNPEQ 616
            ..|:: :..::|.. |..|     ::::.| ::|.         .||..|           |.:|
Human   468 EVQFQ-IDPMTFRLWHQAVDTLPEEQLVVP-DLPTCALPRPWSVPPLRRG-----------NRKQ 519

  Fly   617 MQAVRQIA-LSP---RLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVA 677
            ..||..|| ..|   |...|.:::||.|||||.|:..|..:: |.||||.:|:...:|:|.|...
Human   520 ELAVALIAGWGPGDGRRVPPLLIYGPFGTGKTYTLAMASLEV-IRRPETKVLICTHTNSAADIYI 583

  Fly   678 LRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVH--FYPAVQA-VHQYRIVI 739
            .....:.......:..||..:::   ||.:...|.:.|:|..:....  |.|..:| :.::|:|:
Human   584 REYFHSHVSGGHPEATPLRVMYT---DRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVV 645

  Fly   740 CTLSLAGKLSTG-GFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQ 803
            .|.|.|.:|... ||     ::|:.:||||...|.|.|..:......| .|:|:|||.|:.|.|.
Human   646 TTTSQARELRVPVGF-----FSHILIDEAAQMLECEALTPLAYASHGT-RLVLAGDHMQVTPRLF 704

  Fly   804 S---QRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLI--RNFRSHPEIVSLYNNMYYEG 863
            |   .||.|.    ||..||.  .|||.|   ::..:.|:||:  .|:|....|||..:..:|..
Human   705 SVARARAAEH----TLLHRLF--LCYQQE---THEVARQSRLVFHENYRCTDAIVSFISRHFYVA 760

  Fly   864 -----HLRTEAPMEIVCRFHNWFYLPNAT-FPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVK 922
                 |.|.:.|             |:.. :|:||..|.|:.....|..|..|..||..|::.|:
Human   761 KGNPIHARGKVP-------------PHPRHYPLMFCHVAGSPDRDMSMASWLNLAEIAQVVEKVQ 812

  Fly   923 DL-----MYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIV 982
            :.     ..:|  |.:  |..|.::| :..|...::::|..|:..|:..||.|:..|::..|:::
Human   813 EAYNTWPSCWG--GRE--QRCICVVS-HGAQVSALRQELRRRDLGQVSVGSFEILPGRQFRVVVL 872

  Fly   983 SFVRSFTPKLG-------FLNNERRLNVLLSRPISLLILIGNPRTLSQ----NSDFQHIIEMCRN 1036
            |.|.:....|.       |..:.|.||.:|:|..|.|:::|:...|..    ...::..|..|..
Human   873 STVHTCQSLLSPGALAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVE 937

  Fly  1037 RKTLVGEQYLNEDF---ITNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSK 1098
            |.::..|....|..   :..::.......:.||||:..|            |..||.|
Human   938 RHSVCPEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEA------------APEPVGD------- 983

  Fly  1099 NELLNLGNECQRKKSELETIFDELPKVPRSVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTN 1163
                 |..|                           :...:.|.:|....:.....|...|..|.
Human   984 -----LAEE---------------------------QAAVVTAMVKAEPGDEALSPASRDITATT 1016

  Fly  1164 APVTNAAAPS-------VIPRA 1178
            |....||||:       |:|.|
Human  1017 AQTEAAAAPAGDAVKEDVVPGA 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	169/715 (24%)
		AAA_19	618..687	CDD:289986	25/72 (35%)
		AAA_12	812..1019	CDD:289832	59/226 (26%)
HELZ2	XP_024307774.1	ZnF_U1	39..69	CDD:197732
		AAA_11	541..705	CDD:331082	53/173 (31%)
		UvrD_C_2	715..915	CDD:328976	59/222 (27%)
		RNB	1334..1693	CDD:214935
		AAA_11	2180..2427	CDD:315699
		AAA_12	2434..2639	CDD:315700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810