Protein Alignment CG6701 and HCS1

DIOPT Version :10

• Sequence 1: NP_610920.3
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_012908.1
• Gene: HCS1 / 853852
• SGDID: S000001500
• Length: 683
• Species: Saccharomyces cerevisiae
• Alignment Length: 767
• Identity: 184/767 - (23%)
• Similarity: 314/767 - (40%)
• Gaps: 194/767 - (25%)

  Fly   381 LSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELH 445
            ||::||                  ||.::|   ..|..|.|.|.::.:  :|:.|::....:|..
Yeast    10 LSSIKH------------------EREQDI---QTTSRLLTTLSIQQL--VQNGLAINNIHLENI 51

  Fly   446 QFGRELSVKMQMGTTSMSVEDILSPGD----DVLI-------INEKGNPKSAVRKMLENNNNVLE 499
            :.|....:.|::| .:::|.|.:..||    |:::       :|.|..||  |:|:.|::|.  |
Yeast    52 RSGLIGKLYMELG-PNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPK--VKKVSEDSNG--E 111

  Fly   500 LALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRA 564
            .|            ...|:|..:              |..::.|..|..           :.:.|
Yeast   112 QA------------ECSGVVYKM--------------SDTQITIALEES-----------QDVIA 139

  Fly   565 VMRYQYRALQQL------SFTRHSDVQRILFPGEIPNTPLASGVLQ--LNNKLISTNPEQMQAVR 621
            ...|.|..|..|      ::.|.....|.|  .|| ::|:...::|  :|.:....|....|.::
Yeast   140 TTFYSYSKLYILKTTNVVTYNRMESTMRKL--SEI-SSPIQDKIIQYLVNERPFIPNTNSFQNIK 201

  Fly   622 QIALSPRLKAPY-------------IVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTAC 673
            .. |:|.|....             |:.||||||||.|::|.|.||.|..||..||:...||.:.
Yeast   202 SF-LNPNLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISV 265

  Fly   674 DEVALRLLRAI-----------AKAPQSQPRPLTRIFS-----------------------ANCD 704
            |.:..||...:           |:...|..|....|.|                       .|..
Yeast   266 DTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYK 330

  Fly   705 RRIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANN----VYTHVFVD 765
            :|.:|.:::.|...::....|......:.|.|||:.||..:..........::    ::..:.:|
Yeast   331 QRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIID 395

  Fly   766 EAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANE--WGLGLTLFERLLQRKCYQV 828
            |.:.:.|.:..:.:....:....|:|:||:|||.|.::::....  ..|..|||:|::  |.:.
Yeast   396 EVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRII--KIFP- 457

  Fly   829 EEDGSYNASVQTRL---IRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLP--NAT- 887
            :.|.....:||.|:   |..|.||    |:||     |.|..:|  .:..|.  ...||  :||
Yeast   458 KRDMVKFLNVQYRMNQKIMEFPSH----SMYN-----GKLLADA--TVANRL--LIDLPTVDATP 509

  Fly   888 --------FPIMFHSVFGTT-MNTKSSVSLCNNK----EIDVVMDYVKDLMYFGLNGEKLLQTDI 939
                    .|::::...|.. ..|....::..:|    ||.:|.:::::|..|.:.     :..|
Yeast   510 SEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVP-----ENSI 569

  Fly   940 GIISPYKNQYQR----IQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLGFLNNER 999
            |:||||..|...    |.::|.:   :.|:..:|:.|||:||.|||:|.|||... ::|||..||
Yeast   570 GVISPYNAQVSHLKKLIHDELKL---TDIEISTVDGFQGREKDVIILSLVRSNEKFEVGFLKEER 631

  Fly  1000 RLNVLLSRPISLLILIGNPRTLSQ--NSDFQHIIEMCRNRKTLVGEQYLNED 1049
            ||||.::||...|:::||...|.:  |...:...|.|.....:   :|.|.|
Yeast   632 RLNVAMTRPRRQLVVVGNIEVLQRCGNKYLKSWSEWCEENADV---RYPNID 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_610920.3	DEXXQc_Helz-like	611..847	CDD:350796	67/291 (23%)
		SF1_C_Upf1	848..1035	CDD:350195	62/209 (30%)
HCS1	NP_012908.1	TIGR00376	15..679	CDD:273041	179/759 (24%)