DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and HCS1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_012908.1	Gene:	HCS1 / 853852	SGDID:	S000001500	Length:	683	Species:	Saccharomyces cerevisiae

Alignment Length:	767	Identity:	184/767 - (23%)
Similarity:	314/767 - (40%)	Gaps:	194/767 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 LSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELH 445
            ||::||                  ||.::|   ..|..|.|.|.::.:  :|:.|::....:|..
Yeast    10 LSSIKH------------------EREQDI---QTTSRLLTTLSIQQL--VQNGLAINNIHLENI 51

  Fly   446 QFGRELSVKMQMGTTSMSVEDILSPGD----DVLI-------INEKGNPKSAVRKMLENNNNVLE 499
            :.|....:.|::| .:::|.|.:..||    |:::       :|.|..||  |:|:.|::|.  |
Yeast    52 RSGLIGKLYMELG-PNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPK--VKKVSEDSNG--E 111

  Fly   500 LALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRA 564
            .|            ...|:|..:              |..::.|..|..           :.:.|
Yeast   112 QA------------ECSGVVYKM--------------SDTQITIALEES-----------QDVIA 139

  Fly   565 VMRYQYRALQQL------SFTRHSDVQRILFPGEIPNTPLASGVLQ--LNNKLISTNPEQMQAVR 621
            ...|.|..|..|      ::.|.....|.|  .|| ::|:...::|  :|.:....|....|.::
Yeast   140 TTFYSYSKLYILKTTNVVTYNRMESTMRKL--SEI-SSPIQDKIIQYLVNERPFIPNTNSFQNIK 201

  Fly   622 QIALSPRLKAPY-------------IVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTAC 673
            .. |:|.|....             |:.||||||||.|::|.|.||.|..||..||:...||.:.
Yeast   202 SF-LNPNLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISV 265

  Fly   674 DEVALRLLRAI-----------AKAPQSQPRPLTRIFS-----------------------ANCD 704
            |.:..||...:           |:...|..|....|.|                       .|..
Yeast   266 DTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYK 330

  Fly   705 RRIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANN----VYTHVFVD 765
            :|.:|.:::.|...::....|......:.|.|||:.||..:..........::    ::..:.:|
Yeast   331 QRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIID 395

  Fly   766 EAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANE--WGLGLTLFERLLQRKCYQV 828
            |.:.:.|.:..:.:....:....|:|:||:|||.|.::::....  ..|..|||:|::  |.:.
Yeast   396 EVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRII--KIFP- 457

  Fly   829 EEDGSYNASVQTRL---IRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLP--NAT- 887
            :.|.....:||.|:   |..|.||    |:||     |.|..:|  .:..|.  ...||  :||
Yeast   458 KRDMVKFLNVQYRMNQKIMEFPSH----SMYN-----GKLLADA--TVANRL--LIDLPTVDATP 509

  Fly   888 --------FPIMFHSVFGTT-MNTKSSVSLCNNK----EIDVVMDYVKDLMYFGLNGEKLLQTDI 939
                    .|::::...|.. ..|....::..:|    ||.:|.:::::|..|.:.     :..|
Yeast   510 SEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVP-----ENSI 569

  Fly   940 GIISPYKNQYQR----IQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLGFLNNER 999
            |:||||..|...    |.::|.:   :.|:..:|:.|||:||.|||:|.|||... ::|||..||
Yeast   570 GVISPYNAQVSHLKKLIHDELKL---TDIEISTVDGFQGREKDVIILSLVRSNEKFEVGFLKEER 631

  Fly  1000 RLNVLLSRPISLLILIGNPRTLSQ--NSDFQHIIEMCRNRKTLVGEQYLNED 1049
            ||||.::||...|:::||...|.:  |...:...|.|.....:   :|.|.|
Yeast   632 RLNVAMTRPRRQLVVVGNIEVLQRCGNKYLKSWSEWCEENADV---RYPNID 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	170/710 (24%)
		AAA_19	618..687	CDD:289986	29/92 (32%)
		AAA_12	812..1019	CDD:289832	71/230 (31%)
HCS1	NP_012908.1	TIGR00376	15..679	CDD:273041	179/759 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810