DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and SEN1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_013534.3	Gene:	SEN1 / 851150	SGDID:	S000004422	Length:	2231	Species:	Saccharomyces cerevisiae

Alignment Length:	1063	Identity:	233/1063 - (21%)
Similarity:	386/1063 - (36%)	Gaps:	335/1063 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 LRWARNVDGMVGSLDKQPRVY----FARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQ 569
            :|..:|..|  |::|...|::    |::.|   |.|..|.|.:.:...|            :..:
Yeast  1247 VRTLKNTKG--GNVDVTLRIHRNHSFSKFL---TLRSEIYCVKVMQMTT------------IERE 1294

  Fly   570 YRALQQLSFTRHSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYI 634
            |..|:.|.:  :..|.:||.....|...:.:..::...|....|..|.:|   |..|...:...:
Yeast  1295 YSTLEGLEY--YDLVGQILQAKPSPPVNVDAAEIETVKKSYKLNTSQAEA---IVNSVSKEGFSL 1354

  Fly   635 VFGPPGTGKTSTIVEAI----------------YQLYINRPETH-------ILVLAGSNTACDEV 676
            :.||||||||.||:..|                ..|..|...|.       ||:.|.||.|.||:
Yeast  1355 IQGPPGTGKTKTILGIIGYFLSTKNASSSNVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEI 1419

  Fly   677 ALRLLRAIAKAPQSQPRP-LTRIFSANCDRRIDN--IDDLLLEY-------SNMYTVHFYPAVQ- 730
            .|||...:......|.:| |.|:..::    :.|  |.||.||.       ...|.:...|.::
Yeast  1420 CLRLKSGVYDKQGHQFKPQLVRVGRSD----VVNVAIKDLTLEELVDKRIGERNYEIRTDPELER 1480

  Fly   731 ----AVHQYRIVICTLSLAGKL------------------------------------------- 748
                ||.:.|      .|.|||
Yeast  1481 KFNNAVTKRR------ELRGKLDSESGNPESPMSTEDISKLQLKIRELSKIINELGRDRDEMREK 1539

  Fly   749 ---------------------------STGGFAANNV-------YTHVFVDEAAASTEAEVLM-- 777
                                       ||...:|::|       :..|.:|||...||...::
Yeast  1540 NSVNYRNRDLDRRNAQAHILAVSDIICSTLSGSAHDVLATMGIKFDTVIIDEACQCTELSSIIPL 1604

  Fly   778 ---GITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGS-YNASV 838
               |..|        |:.||..||.|.:.|..|:.:....:||.|:        |::.| |...|
Yeast  1605 RYGGKRC--------IMVGDPNQLPPTVLSGAASNFKYNQSLFVRM--------EKNSSPYLLDV 1653

  Fly   839 QTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYL-PNATFPIMFHSVFGTTMNT 902
            |      :|.||.|....::.:|:|.|:....|:|:.: ..|..| |.|.:. .|..:.|.....
Yeast  1654 Q------YRMHPSISKFPSSEFYQGRLKDGPGMDILNK-RPWHQLEPLAPYK-FFDIISGRQEQN 1710

  Fly   903 KSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQL-----NMRNWS 962
            ..::|..|.:||.|.::.| |.::...:.:......|||||||:.|.|:::::.     .|.|.|
Yeast  1711 AKTMSYTNMEEIRVAIELV-DYLFRKFDNKIDFTGKIGIISPYREQMQKMRKEFARYFGGMINKS 1774

  Fly   963 QIDCGSVELFQGKEKHVIIVSFVRSFTPK--LGFLNNERRLNVLLSRPISLLILIGNPRTLSQNS 1025
             ||..:::.|||:||.:|::|.||:...|  :|||.:.||:||.|:|..:.:.::|:.|:|:::.
Yeast  1775 -IDFNTIDGFQGQEKEIILISCVRADDTKSSVGFLKDFRRMNVALTRAKTSIWVLGHQRSLAKSK 1838

  Fly  1026 DFQHIIEMCRNRKTLV--------------------------GEQ----YLNEDFIT-------- 1052
            .::.:||..::|..|.                          .||    .|..::||
Yeast  1839 LWRDLIEDAKDRSCLAYACSGFLDPRNNRAQSILRKFNVPVPSEQEDDYKLPMEYITQGPDEVKS 1903

  Fly  1053 NKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELET 1117
            ||.|....|...|...|: |...::..|:|...|:...|.|....|.|..:..:..::|.|
Yeast  1904 NKDTKKRRVVDEGEEADK-AVKKKKKEKKKEKKKSKADDKKKNNKKAESPSTSSGTKKKSS---- 1963

  Fly  1118 IF---------------------------------------DELPKVPRSVDHDLDEVRSIEAQL 1143
            ||                                       |::..:||:.:.::...||:.:.|
Yeast  1964 IFGGMSVPSAVVPKTFPDVDSNKKAAAVVGKKKNNKHVCFSDDVSFIPRNDEPEIKVTRSLSSVL 2028

  Fly  1144 KDFQLETKQDAAGTSILVTNAPVTNAA--------APSVIPRAGLMKQET------PALHSSSVS 1194
            |:.||..|:...     ::...::|..        .|| |..:.|||.|.      .|.|:.:.|
Yeast  2029 KEKQLGLKETRT-----ISPPEISNNEDDDDEDDYTPS-ISDSSLMKSEANGRNNRVASHNQNFS 2087

  Fly  1195 RPAIRKPTVSAATPVAKSRSPMPEIPSS-SKHPISMSSNPLSTNTERCVNGVLCGIEAVPPSEN- 1257
            ......|.||.|        ...::|:: :||  ..|::.||..:.|    :|...:...|::|
Yeast  2088 ASIYDDPQVSQA--------KQTQVPAAITKH--RSSNSVLSGGSSR----ILTASDYGEPNQNG 2138

  Fly  1258 ----------KTTRSSAYNHIPSGNFRFENVRPT------PEEVRRFNGANDQRRARPFREPHGN 1306
                      ....::.|:..|.|........|.      |.|      |.|.....|..:|..:
Yeast  2139 QNGANRTLSQHVGNANQYSTAPVGTGELHETLPAHPQDSYPAE------AEDPYDLNPHPQPQSS 2197

  Fly  1307 WSNFGWSPPPRDPTPPRRNKKFN 1329
                .:..|...||..|.:.:.|
Yeast  2198 ----AFKGPGSGPTGTRNSSRRN 2216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	158/660 (24%)
		AAA_19	618..687	CDD:289986	28/91 (31%)
		AAA_12	812..1019	CDD:289832	64/215 (30%)
SEN1	NP_013534.3	SEN1_N	106..859	CDD:403815
SEN1	NP_013534.3	DNA2	1006..1858	CDD:224037	160/668 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740