DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Helz

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_938040.1	Gene:	Helz / 78455	MGIID:	1925705	Length:	1965	Species:	Mus musculus

Alignment Length:	1385	Identity:	297/1385 - (21%)
Similarity:	504/1385 - (36%)	Gaps:	404/1385 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 RGIASTTDVPGGAPAEGNKPIIEEYKL-----------------DTDVKPTLLKFQKRL---LLQ 201
            |||.|:                |||.|                 ....:..|.::|||.   |::
Mouse   173 RGITSS----------------EEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIK 221

  Fly   202 SDKDFELQSL-GCY----------------ICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYP 249
            ..:..|.:.| |.|                :..|..|.::     ||:..|.|...:.||
Mouse   222 LKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQ-----VEHSPDLSVTVNTKK----- 276

  Fly   250 TPIVSLSYQTCVDSHYFGFTLK----TFRKDLVVD----KFIIV---------QLRQFYYVYGAQ 297
                  |:||..    |..|.|    .:|..|:.|    .|.|:         |:.|       :
Mouse   277 ------SHQTWT----FALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQ-------E 324

  Fly   298 MP----------LPVNGSGELVFFV----DSHVFMILREQPIVIGFTIQGEKYVEQHHFMRTEAL 348
            :|          :..||....|:.|    ::.:|...| |.||..|.::..       .|:...:
Mouse   325 VPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFR-QTIVFDFGLEPV-------LMQRVMI 381

  Fly   349 PKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERG------ 407
            ..||.....|.:.:|...             |.:|.:.:.:...:..|:.......|:.
Mouse   382 DAASTEDLEYLMHAKRQL-------------VTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQ 433

  Fly   408 ---------------REITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQM 457
                           :.:|:.|....|..||.:|:|.:.:          |:.:|  .|.|::|:
Mouse   434 IPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYK----------EVSRF--NLKVQLQI 486

  Fly   458 GTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLE----------LALKDFDSILRWA 512
            ..:.|             :....|..|.|....|.....:.|          |.:...:::....
Mouse   487 LASFM-------------LTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLP 538

  Fly   513 RNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRP---LRAVMRYQYRAL- 573
            ...:.:|.|...:.:||.|.|...:...|.:...|:..:.    |..||   ::..:::|...|
Mouse   539 VPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRECCEE----LSLRPDCDIQVELQFQLNRLP 599

  Fly   574 ---QQLSFTRHSDVQRILFPG-----EIPNTPLASGVLQLNNKLISTNPEQMQAVRQIA--LSPR 628
               ...:..|..| ..:|||.     .||.:|......||:.:|   |.:|.:||..|.  ||.:
Mouse   600 LCEMHYALDRIKD-NAVLFPDISMTPTIPWSPNRQWDEQLDPRL---NAKQKEAVLAITTPLSIQ 660

  Fly   629 LKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPR 693
            | .|.::.||.|||||.|:.:|...:...:..:.||:...||:|.|......|....:|...|.|
Mouse   661 L-PPVLIIGPYGTGKTFTLAQAAKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQAR 724

  Fly   694 PLTRIFSANCDRRIDNIDDLLLEY---SNMYTVHFYPAVQAVHQYRIVICTLSLAGKLS----TG 751
            || |::..|  |.:..:..::.:|   |:..:....|..:.:.::|:|:.|||.:..|.    ..
Mouse   725 PL-RVYFRN--RWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEP 786

  Fly   752 GFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTL 816
            ||     :|||.:||||.:.|.|.:|.:......| .::|:|||.||.|.:.|:.|.|..|.::|
Mouse   787 GF-----FTHVLLDEAAQAMECETIMPLALATKNT-RIVLAGDHMQLSPFVYSEFARERNLHVSL 845

  Fly   817 FERLLQRKCYQVEEDGSYNASVQTRLI--RNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHN 879
            .:||.:.          |.|....|::  .|:|||..|::..:.::|||.|........    |.
Mouse   846 LDRLYEH----------YPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPA----HK 896

  Fly   880 WFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDL-----MYFGLNGEKLLQTDI 939
            .||      |:.|.:..|..:..|:|.:..||.|:..|::.|::|     :.:|    ||....|
Mouse   897 DFY------PLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWG----KLDDGSI 951

  Fly   940 GIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRS-------FTP------- 990
            |:::||.:|..||:.:|..:..|.::...|...|||:..|:.:|.||:       .||
Mouse   952 GVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQL 1016

  Fly   991 --------KLGFLNNERRLNVLLSRPISLLILIGNPRTLSQ----NSDFQHIIEMCRNRKTLVGE 1043
                    ..|||:|.:.||..::|..||:.::|:|..|..    ...::..|.:|....:|.|.
Mouse  1017 LEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGI 1081

  Fly  1044 QYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKN-ELLNLGNE 1107
            .:                       :|..:.|.....:|.:..||:  |..|..:. .|.:.||.
Mouse  1082 TF-----------------------EQIKAQLEALELKKTYVLNPL--APEFIPRALRLQHSGNS 1121

  Fly  1108 CQRKKSELETIFDELPKVPRSVDHDLDEVRSIEAQLKDFQLETKQDA---AGTSILVTNAPVTNA 1169
            .::::|.        ||| :|:.|         .|...||    .|.   ...|:|:.|......
Mouse  1122 SRQQQSP--------PKV-KSLYH---------PQSDHFQ----SDGIVQPNPSVLIGNPIRAYT 1164

  Fly  1170 AAPSVIPRAGLMKQETPALH------SSSVSRPAIRKPTVSAATPVAKSRSPMPEI--------- 1219
            ..|.:.|...|.|..:|...      :|.:..||:....|..:.|:     |:|..
Mouse  1165 PPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPL-----PVPWTGYQGRFAVD 1224

  Fly  1220 PSSSKHPISMSSNPLSTNTERCVNGVLCGIEAVPP----------------SENKTTRSSAYNHI 1268
            |....|..:|:.|....:|....:.:..|:...||                .:|:..::...|..
Mouse  1225 PRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPG 1289

  Fly  1269 PSGN-FRFENVRPT-PEEVRRFNGANDQRRA---------------------------RPFREPH 1304
            |..| .|....:|| |::|..  .:|.|.|:                           .|...||
Mouse  1290 PEINKIRTPEKKPTEPKQVDL--ESNPQNRSPESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPH 1352

  Fly  1305 GNWS--NFGWSPPPRDPTPP 1322
            ..::  :..:.|.|:.|.||
Mouse  1353 AQYAIPSRHFHPLPQLPRPP 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	169/676 (25%)
		AAA_19	618..687	CDD:289986	23/70 (33%)
		AAA_12	812..1019	CDD:289832	62/235 (26%)
Helz	NP_938040.1	zf-CCCH	181..204	CDD:366217	2/22 (9%)
		DEXXQc_HELZ	641..868	CDD:350835	74/249 (30%)
		DEAA box	795..798		2/2 (100%)
		SF1_C_Upf1	869..1069	CDD:350195	55/213 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1136		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1249..1351		16/103 (16%)
		Atrophin-1	1262..>1416	CDD:367360	20/113 (18%)
		Amelogenin	<1338..>1414	CDD:197891	8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1380		5/12 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1389..1450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1632..1656
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820