DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and zgc:154086

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001070795.1	Gene:	zgc:154086 / 768184	ZFINID:	ZDB-GENE-061013-333	Length:	1106	Species:	Danio rerio

Alignment Length:	807	Identity:	222/807 - (27%)
Similarity:	354/807 - (43%)	Gaps:	188/807 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 HFMRTEALPKASFNINPYRL-----SSKETFKSKGLPPANP--------PIQVLS-ALKHEDAQM 391
            ||        :||.|. .||     |.:|...:..:|..:|        |:|||: :......::
Zfish   373 HF--------SSFTIG-RRLELSVSSVEEQLLNPSMPYCSPSAPAQLPQPLQVLTVSAPPTPLRL 428

  Fly   392 CLASFDNQYQNY--------CERGRE---ITQENLTG--TLRTLLQVEDIERLQHYLSLK--QSE 441
            ......|...||        |...::   :.|..|..  :|||:|     .|....|.|:  |:|
Zfish   429 TRRHLPNFLGNYGVPQALRECVEAQKDVLVVQPALAEALSLRTML-----PRFSALLWLEELQAE 488

  Fly   442 MELHQFGRELSVKMQMGTTSMSVE-DILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDF 505
            .|:.:|....:: ::.|...:.:| ..|:.|...|.|.:|     .|.|...:...|:|
Zfish   489 REIREFSLTGAI-LRRGAVYLHLEVPGLAEGRPSLFIGDK-----VVLKKPCSGGVVIE------ 541

  Fly   506 DSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPL-------R 563
                                   |.|.:..:|.:.|::....:.  .::|  :..||       |
Zfish   542 -----------------------YIAYVTEISDEDVSLRVNAEF--QSSY--LGEPLDVEFSFNR 579

  Fly   564 AVMRYQYRALQQLSFTRHSDVQRILFP--------------------------GEIPNTPLASGV 602
            ..||..:.||:|   ::|.. :.||||                          ||...|...|.:
Zfish   580 LTMRRCHCALEQ---SKHFG-ENILFPSMLQLQAPQWSGEWGPQEEQDEELKDGEQTQTVTGSAL 640

  Fly   603 --------------LQLNNKLIST-----NPE----QMQAVRQIALSPRLKAPYIVFGPPGTGKT 644
                          |.:..|.|..     ||:    |.||||:|........||::|||||||||
Zfish   641 TAEMVSVATQTKTDLSVTEKRIPNPGQFFNPDLNAAQKQAVRRILSGESRPTPYVLFGPPGTGKT 705

  Fly   645 STIVEAIYQLYINRPETHILVLAGSNTACDEVALRL-----LRAIAKAPQSQPRPLTRIFSANCD 704
            .|::|||.|::.....:.:||...||:|.|.:.:||     |.:.:         |.|: :|.|
Zfish   706 ITLIEAILQVHHRISCSRVLVCTPSNSAADLICMRLHHSGFLHSAS---------LARV-NATC- 759

  Fly   705 RRIDNIDDLLLEYSNMYTVHFYPAVQAVHQ---YRIVICTLSLAGKLSTGGFAANNVYTHVFVDE 766
            |..:::.:.|.:|:.        |.:.:..   :|||:.|.|.||.....|....: :|||||||
Zfish   760 RPEESMSEELRQYAR--------AGEDIRHASFHRIVVSTCSSAGMFYQIGLRVGH-FTHVFVDE 815

  Fly   767 AAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEED 831
            |..:||.|.|:.::.....:..::|:||.||||||::|:.|:.:|||::|.|||:....|...|.
Zfish   816 AGQATEPETLIPLSLLSETSGQIVLAGDPKQLGPVVKSRLASVFGLGVSLLERLMGNSLYACGER 880

  Fly   832 GSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVF 896
            | :|..:.|:|:.|:|||..::.|.:.::|.|.|...|....|....:|..||...||::||.|.
Zfish   881 G-FNPLLVTKLLYNYRSHEALLDLPSRLFYAGELCVRAQRAAVDSLCHWNKLPTRGFPLIFHGVR 944

  Fly   897 GTTMNTKSSVSLCNNKEIDVVMDYVKDL---MYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNM 958
            |:.|....:.|..|..|...||.|...|   :|     ..:...|||:|:||:.|.::|:..|..
Zfish   945 GSEMREGCNPSWFNPAEAVQVMMYCCQLAKRLY-----NPISAADIGVIAPYRKQVEKIRVLLQR 1004

  Fly   959 RNWSQIDCGSVELFQGKEKHVIIVSFVRS--------FTPKLGFLNNERRLNVLLSRPISLLILI 1015
            ....::..||||.|||:|..::|:|.|||        ....||||:|.:|.||.::|..:|||:|
Zfish  1005 VGLGEVKVGSVEEFQGQEFLIMILSTVRSNESLLNEELQCMLGFLSNPKRFNVAITRAKALLIVI 1069

  Fly  1016 GNPRTLSQNSDFQHIIEMCRNRKTLVG 1042
            |||..|.:...|..:::...:.:..:|
Zfish  1070 GNPHVLIKEPCFSALLQYSYDNRAFIG 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	196/690 (28%)
		AAA_19	618..687	CDD:289986	30/73 (41%)
		AAA_12	812..1019	CDD:289832	77/217 (35%)
zgc:154086	NP_001070795.1	S1-like	45..97	CDD:291136
		AAA_11	672..854	CDD:289831	68/201 (34%)
		P-loop_NTPase	673..>850	CDD:304359	66/196 (34%)
		AAA_12	861..1072	CDD:289832	76/216 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010