DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_017175214.1	Gene:	Zgrf1 / 71643	MGIID:	1918893	Length:	2044	Species:	Mus musculus

Alignment Length:	857	Identity:	207/857 - (24%)
Similarity:	334/857 - (38%)	Gaps:	241/857 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 EALPKASFNINPYRLSSKETFKS-KGLPPA---NPPIQVLSALKHEDAQ-----MCLASFDNQ-- 399
            :||.|.  :|:.|..|..||.:| |...|:   |.|.:::...|....:     .|..|.|||
Mouse  1241 KALSKV--DISFYTSSKGETMRSGKNNSPSCHHNQPAKLVMVKKEGPNKGRLFYTCDKSKDNQCK 1303

  Fly   400 YQNYCERGREITQENL-TGTLRTLLQVEDIERLQHYL---------------------------S 436
            :..:.|   |:|...| ..|.::.:...||:.:..||                           .
Mouse  1304 FFKWLE---EVTPGQLPQNTSQSTMVFNDIKSIGSYLRSQKVPVYEECQLLLRRGFDFQRKQCGK 1365

  Fly   437 LKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGD------------DVLIINEKGNPKSAVRK 489
            ||:.......|..|...|:.:..:......:.|.||            |..|........|:|
Mouse  1366 LKKLTTVNPDFYSETKSKIYLKLSRRESSSVYSKGDLWVISKTLDFELDTFIACSAFFGPSSV-- 1428

  Fly   490 MLENNNNVLELALKD-FDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNT 553
                 |.|..|.||. |.|  .|..|:           .|:...:...||:   :|..:.:.|
Mouse  1429 -----NEVELLPLKGYFPS--NWPTNI-----------TVHALLVCNASTE---LTTLQNIQD-- 1470

  Fly   554 TYTLIFRPLR-AVMRYQYRALQQLSFTRHSDVQRILFPGEIPN----TPLASG-VLQLNNKLIST 612
                .|.|.. .:|.|.....|..:.:..:..:|...|..|.:    |.|..| .|||..:||:.
Mouse  1471 ----YFNPAALPLMPYLLAMSQSATVSSKNISKRKFIPPAITSIKTKTELHLGATLQLARELINV 1531

  Fly   613 ---NPEQMQAVRQIALSPRLKA----------PY-------IVFGPPGTGKT---STIVEAIYQL 654
               |.:|..|:.|||   ::.|          |:       ::.|..|.||:   :.::..:.:|
Mouse  1532 HRLNKDQATALIQIA---QMMASQGSDEDALEPFGHSLPITVIHGVFGAGKSYLLAVVILFLVEL 1593

  Fly   655 YI--------NRPETHILVLAGSNTACDEVALRLL-------------RAIAK--APQSQPRPLT 696
            :.        |.....:||.:.:|.|.|.|.|.||             |.|||  .|.|
Mouse  1594 FEKCDSGTVGNARPWKVLVSSSTNVAVDRVLLGLLSLGFEKFIRVGSVRKIAKPVLPYS------ 1652

  Fly   697 RIFSANCDRRIDNIDDL--LL--EYSNMYTVHFYPAVQ---------AVHQYRIVICTLSLAGKL 748
              ..|..|...:.:.:|  ||  |.:.:..|:...:::         .:.|.|:|..|.:..
Mouse  1653 --LHAGSDNESEQLKELNALLKEELTPIERVYVRKSIEQHKLGTNRVLLKQVRVVGVTCAAC--- 1712

  Fly   749 STGGFAANN--VYTHVFVDEAAASTEAEVLMGIT---CTLSPTLNLILSGDHKQLGPVLQ-SQRA 807
               .|...|  .:..|.:||.:..||...|:.|.   |.     .|||.||.|||.|.:| |..|
Mouse  1713 ---AFPCLNDLKFPVVVLDECSQMTEPASLLPIARFQCE-----KLILVGDPKQLPPTIQGSDAA 1769

  Fly   808 NEWGLGLTLFERLLQRKC---------------YQVEEDGSYNASVQTRLIRNFRSHPEIVSLYN 857
            :|.||..|||:||....|               :..:|:|.....::|:    :|.||.|.::.|
Mouse  1770 HENGLEQTLFDRLCLMACTSKMLQVTAGCRLCGWMKDEEGHKPVLLRTQ----YRCHPAISAIAN 1830

  Fly   858 NMYYEGHL------RTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDV 916
            :::|||.|      |..:|:      ..|  ||.    :.|::|.|.....:.: |..|..|...
Mouse  1831 DLFYEGSLVNGISERERSPV------LEW--LPT----LCFYNVTGAEQVEREN-SFVNVAEATF 1882

  Fly   917 VMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCG----------SVEL 971
            .:..::.||..|:  |..:   ||:|:.||:|..:|...|     |.:|.|          :|:.
Mouse  1883 TLKLIQSLMASGV--ESCM---IGVITLYKSQMYKICNLL-----SAVDVGHPDVKAVQVSTVDA 1937

  Fly   972 FQGKEKHVIIVSFVRSFTPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRN 1036
            |||.||.:.|:|.||  |.::||:::|:|:||.|:|....|:::|:...|.:|..:..:|:.|..
Mouse  1938 FQGAEKEITILSCVR--TRQVGFIDSEKRMNVALTRGRRHLLIVGSLSCLRKNRLWGRVIQHCEG 2000

  Fly  1037 RKTLVGEQYLNE 1048
            |:.  |.|:.::
Mouse  2001 RED--GLQHASQ 2010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	180/754 (24%)
		AAA_19	618..687	CDD:289986	25/111 (23%)
		AAA_12	812..1019	CDD:289832	66/237 (28%)
Zgrf1	XP_017175214.1	DUF2439	3..75	CDD:371019
		zf-GRF	1267..1311	CDD:284302	10/46 (22%)
		TIGR00376	<1568..2003	CDD:273041	127/482 (26%)
		AAA_12	1774..1981	CDD:372468	65/235 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740