DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and ZNFX1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_066363.1	Gene:	ZNFX1 / 57169	HGNCID:	29271	Length:	1918	Species:	Homo sapiens

Alignment Length:	1212	Identity:	220/1212 - (18%)
Similarity:	398/1212 - (32%)	Gaps:	456/1212 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VISAQTEWYVDKAKMRKLF----EVHLNALPNSSEIRQKLSSQGATNIGSLLHRTNF------LI 123
            ::..:.|.:|:..:...::    ||||:..|   .:|..:.| |..:..::...|:|      .:
Human   321 LVQPEAEDHVESYRTMPIYPTYNEVHLDERP---FLRPNIIS-GKYDSTAIYLDTHFRLLREDFV 381

  Fly   124 NTPRGNPNYRIKNFSLMDFRKEKFNLLDEQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVK 188
            ...|......:::|.....||.||:.:......|.|         .|...:..|:  ||:..|.|
Human   382 RPLREGILELLQSFEDQGLRKRKFDDIRIYFDTRII---------TPMCSSSGIV--YKVQFDTK 435

  Fly   189 PTLLKF-----QKRLLLQSDKDFELQSLGCYIC--QENFE-----KIEKYEEH------VEYHGD 235
            |  |||     .||||           .|..:|  ::|||     .:...|:.      |:...:
Human   436 P--LKFVRWQNSKRLL-----------YGSLVCMSKDNFETFLFATVSNREQEDLCRGIVQLCFN 487

  Fly   236 ESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGFTLKTFRKDLVVDKFIIVQLRQFYYVY-----G 295
            |...|.|.:::  |:                             |.|::|:...::..|     |
Human   488 EQSQQLLAEVQ--PS-----------------------------DSFLMVETTAYFEAYRHVLEG 521

  Fly   296 AQ------MPLPVNGSGELVFFVDSHV-------------FMILREQPIVIGFTIQGEKYVEQHH 341
            .|      :|...|     :...:|||             |..|.|.|...|            .
Human   522 LQEVQEEDVPFQRN-----IVECNSHVKEPRYLLMGGRYDFTPLIENPSATG------------E 569

  Fly   342 FMR-TEALPKASFNI-NPYRLSSKETFK-----SKGLPPA---------NPP--------IQVLS 382
            |:| .|.|.....|: :|.:..|||..|     .:.|..|         .||        ::::.
Human   570 FLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGLKIVQ 634

  Fly   383 ALKHEDA--QMCLASFDNQ---YQNY-----------CER-------GREITQENLTGTLRTLLQ 424
            ||...::  |:.|..|...   |.|:           |::       ||..::.....|||.|..
Human   635 ALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRN 699

  Fly   425 VEDIER------LQHYLS----LKQSEMELHQFGRELSVKMQMGTTSMSVEDILSP--------- 470
            ..:..|      .:.|:|    :|:||.|||:..:.|...|:.......::..:||
Human   700 KREFRRNLPMHLRRAYMSIMTQMKESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWESLMNG 764

  Fly   471 ---------------------------------------------GDDVLIINEKGNPKSAVRKM 490
                                                         ||:    .|:|..:|::.::
Human   765 PVQDSEWICFQHWKHSMMLEWLGLGVGSFTQSVSPAGPENTAQAEGDE----EEEGEEESSLIEI 825

  Fly   491 LENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARIL-----GVSTQRVNITCERQLP 550
            .|..:.:....:.:.:.::|..|......|:..:..::..|..|     |.:..:...|.|.|
Human   826 AEEADLIQADRVIEEEEVVRPQRRKKEESGADQELAKMLLAMRLDHCGTGTAAGQEQATGEWQ-- 888

  Fly   551 DNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPE 615
                          ..|.|.:.:::    |..|..|.|                  |.:.:....
Human   889 --------------TQRNQKKKMKK----RVKDELRKL------------------NTMTAAEAN 917

  Fly   616 QMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRL 680
            :::.|.|:.||.|                       :|||
Human   918 EIEDVWQLDLSSR-----------------------WQLY------------------------- 934

  Fly   681 LRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRI-----VIC 740
                        |...:::.|:..|:|       |.|...|..    :.:.:.:.|:     ::.
Human   935 ------------RLWLQLYQADTRRKI-------LSYERQYRT----SAERMAELRLQEDLHILK 976

  Fly   741 TLSLAGKLSTGGFAANNVYTH-----VFVDEAAASTEAEVLMGITCTLSPTL-NLILSGDHKQLG 799
            ...:.|..:||......:...     |.|:|||...||..:    .|||... :|||.|||:||.
Human   977 DAQVVGMTTTGAAKYRQILQKVEPRIVIVEEAAEVLEAHTI----ATLSKACQHLILIGDHQQLR 1037

  Fly   800 PVLQ-SQRANEWGLGLTLFERLLQ------------RKCYQVEEDGSYNASVQT-RLIRNFRSHP 850
            |... ...|..:.|.::|||||::            |.|.::       |.:.| .:.::..:||
Human  1038 PSANVYDLAKNFNLEVSLFERLVKVNIPFVRLNYQHRMCPEI-------ARLLTPHIYQDLENHP 1095

  Fly   851 EIV------SLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLC 909
            .::      .:.:|:::..|                      .||         ....:...|..
Human  1096 SVLKYEKIKGVSSNLFFVEH----------------------NFP---------EQEIQEGKSHQ 1129

  Fly   910 NNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQG 974
            |..|...|::..|   ||..  ::.|.:.|.|::.|..|...:::.:..:.::.:....|:.:||
Human  1130 NQHEAHFVVELCK---YFLC--QEYLPSQITILTTYTGQLFCLRKLMPAKTFAGVRVHVVDKYQG 1189

  Fly   975 KEKHVIIVSFVRSFTP-KLGFLNNERRLNVLLSRPISLLILIGNPR-------------TLSQNS 1025
            :|..:|::|.|||... |:|||....|:.|.|||....:..|||.:             ||.:|:
Human  1190 EENDIILLSLVRSNQEGKVGFLQISNRICVALSRAKKGMYCIGNMQMLAKVPLWSKIIHTLRENN 1254

  Fly  1026 DFQHIIEMCRNRKTLVGEQYLNEDFITNKKTGANNVNKGGAA 1067
            ....::.:|       .:.:.....:.:|.:....|.:||.:
Human  1255 QIGPMLRLC-------CQNHPETHTLVSKASDFQKVPEGGCS 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	127/726 (17%)
		AAA_19	618..687	CDD:289986	8/68 (12%)
		AAA_12	812..1019	CDD:289832	49/226 (22%)
ZNFX1	NP_066363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..140
		AAA_11	597..1038	CDD:289831	91/557 (16%)
		AAA_19	604..>667	CDD:289986	11/62 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..819		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..896		5/35 (14%)
		DNA2	<903..1254	CDD:224037	94/486 (19%)
		AAA_12	1051..1234	CDD:289832	48/225 (21%)
		NF-X1-zinc-finger	1372..1417	CDD:100116
		NF-X1-zinc-finger	1461..1505	CDD:100116
		LELP1	<1498..1562	CDD:291701
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810