DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and mov10a

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_002662576.2	Gene:	mov10a / 566858	ZFINID:	ZDB-GENE-091230-8	Length:	1001	Species:	Danio rerio

Alignment Length:	1004	Identity:	297/1004 - (29%)
Similarity:	456/1004 - (45%)	Gaps:	235/1004 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 STTDVPGGAPAEGN------KPII-EEYKLDTDV-------KPTLLKFQKRLLLQSDK------- 204
            ::...|...||..:      |||: .:.||.|::       :..|:|.:..:.:.||.
Zfish    92 TSPSAPDSDPASSSSPRPTFKPILTPKKKLATEILNKLRSKRAELIKDKGGIEISSDPKATKGNV 156

  Fly   205 DFELQSLGCYICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGF- 268
            .|.::.||....             |::|                  ||:.| :.|:   ||.:
Zfish   157 SFTIEELGKLFV-------------VKFH------------------IVNQS-EGCI---YFTYY 186

  Fly   269 -TLKTFRKDLVVDKFIIVQLRQFYYV----YGAQMPLPVNGSGEL---VFF-----VD----SHV 316
             .|...|...:|||..:.::......    |..::...||..|..   ::|     ||    :..
Zfish   187 TALHKMRCFTLVDKRRVNRVSPLLLCPGEDYDVEVHYNVNHPGHFPATMYFEFCPEVDPPGTAKP 251

  Fly   317 FMILREQPIVIGFTIQGEKYVEQHHFMRT---EAL-PKASFNINP-YRLSSKETFKSKGLPPANP 376
            |.|:||...|:                ||   |.| |::.:|... .||..|.....:|:||.
Zfish   252 FCIVRELEAVV----------------RTGLAETLGPESPYNPKQNRRLRPKSKVVEEGVPPE-- 298

  Fly   377 PIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSE 441
                 |::.|:...|...   |||: |....:|:.:..|          ||.|.|.  .||||
Zfish   299 -----SSITHDLKNMMKM---NQYR-YPAYLKELAKYKL----------EDSEHLP--ASLKQ-- 340

  Fly   442 MELHQFGRELSVKMQMGTTS------MSVEDILSPGD----DV---LIINEKGNPKSAVRK---M 490
             .|.:..|.|..::.|...|      :.:|:|....|    |:   .:..:|.|.|..:.|   :
Zfish   341 -HLPRVRRLLDTQLCMKNYSERFHLLLHLEEIQMEVDIKKYDLYGKTMTLDKTNKKLLILKVPGV 404

  Fly   491 LENNNNV-----LELALKDFDSILRWARNVDGMVGSLDKQP-RVYFARILGVSTQRVNITCERQL 549
            .||..:|     |.:.|.|       .||          || .||...:..|...:|.:...|:|
Zfish   405 AENRPSVLRGDKLNVCLSD-------DRN----------QPITVYEGYVHRVELDKVILGFSRKL 452

  Fly   550 ----PDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFP-------GEIPNTPLASGVL 603
                .:|..:.:.|...|..:|.|:||::..  .:|: :..:|||       .|:|:       |
Zfish   453 LQKFVNNMKFDVEFNINRFPLRLQHRAVELA--VQHA-LGNVLFPSDKDTGHSELPH-------L 507

  Fly   604 QLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAG 668
            .:.||.:..||||..||:.|.......|||::|||||||||.|:||||.|:..::.::|||..|.
Zfish   508 SMFNKDLENNPEQKAAVQHILSGSSRPAPYLIFGPPGTGKTVTVVEAIKQVDKSKAQSHILACAP 572

  Fly   669 SNTACDEVALRLLRAIAK-------APQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVH-- 724
            ||:|||.:..|||..:..       ||...||               .:...||::||.....
Zfish   573 SNSACDLLCERLLGHVDAHRIYRLCAPSRDPR---------------TVPQKLLKHSNWNEAQDS 622

  Fly   725 -FYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTL- 787
             ..|:.:.:..|.|::.||..||:|.:||.|..: :||:|:|||..:.|.|.::||...|.|..
Zfish   623 FLLPSKETLIGYSIIVVTLVTAGRLVSGGVAMGH-FTHIFIDEAGQAVEPECIIGIAGLLDPLKG 686

  Fly   788 NLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKC-YQVEED--GSYNASVQTRLIRNFRSH 849
            .|:|:||.:||||||:|..|...|||.:|.|||::|.. ||..:|  ..|::...|:|:||:|||
Zfish   687 QLVLAGDPQQLGPVLRSPLAQLHGLGQSLLERLMKRNALYQKSQDDNSKYDSRFVTKLLRNYRSH 751

  Fly   850 PEIVSLYNNMYYEGHLR---TEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNN 911
            |.|:.:.|.::||..|:   .:...|..|:   |.:||...||::||.|.|......:|.|..|.
Zfish   752 PAILKIPNELFYENELQVFANQMEREAFCQ---WEHLPRKGFPVVFHGVMGKDEREANSPSFFNV 813

  Fly   912 KEIDVVMDYVKDLMYF-GLNG-EKLLQTDIGIISPYKNQYQRIQEQLN----MRNWSQIDCGSVE 970
            .||:|:::|:.:||.. |..| .||...|||||:||:.|.::|::.||    ::.|..|..||||
Zfish   814 TEIEVIVNYLNNLMQTQGKKGLPKLGPNDIGIIAPYRKQVEKIRKALNTVGELKKWKDIKVGSVE 878

  Fly   971 LFQGKEKHVIIVSFVRSFTP--------KLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDF 1027
            .|||:|:.|||||.|||...        .:|||:||:|.||.::|...|||::|||..||::..:
Zfish   879 EFQGQERKVIIVSTVRSSVNYVKMDQDFNIGFLSNEKRFNVAMTRAKGLLIVVGNPVILSKDPTW 943

  Fly  1028 QHIIEMCRNRKTLVGEQYLN----EDFIT 1052
            |..|:.|...:...|..|.:    ||.::
Zfish   944 QKFIQYCEQEQGYTGFDYKDAEGEEDVVS 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	231/676 (34%)
		AAA_19	618..687	CDD:289986	33/75 (44%)
		AAA_12	812..1019	CDD:289832	91/226 (40%)
mov10a	XP_002662576.2	P-loop_NTPase	517..>709	CDD:304359	80/207 (39%)
		AAA_11	517..704	CDD:289831	78/202 (39%)
		DNA2	<634..963	CDD:224037	134/332 (40%)
		AAA_12	711..934	CDD:289832	90/225 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4307
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.680