DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and setx

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	1469	Identity:	281/1469 - (19%)
Similarity:	477/1469 - (32%)	Gaps:	595/1469 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 INNNNGNATP--PDFPTPPPTPPINAG-----IKPPGTYANGMPRKPT-----VPWERELMGSFL 61
            |:.::|:.||  ||| |....||.||.     :||..:..:....||:     .|..|.  .|.:
Zfish  1313 IDTDSGSDTPGQPDF-TDKNVPPSNAANDHLFLKPGMSPMSQKKAKPSTTKIYTPSSRS--ASLV 1374

  Fly    62 LEM--------------ARL-QVISAQTEWYVDKAKM--RKLFE-VHLNALPNSSEIRQKLSSQG 108
            |||              |:: ::.||.....:...||  .|:|: :....||....::|....||
Zfish  1375 LEMEKGAKPPPPANVAKAKIPRLASAMPPPAMPPPKMPPPKMFQPLPPPQLPKPPALKQVTLPQG 1439

  Fly   109 ATNIGSLLHRTNFLINTPRGNPNYRIKNFSLMDFRKEKFNLLDEQHRLRGIASTTDVPGGAPAEG 173
              ::..|:  |:..|::....|:|:                         :....:.|...|.
Zfish  1440 --SVPKLV--TSNKISSTSEPPSYK-------------------------VYQRPEAPVNKPV-- 1473

  Fly   174 NKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYHGDESD 238
            |||:           ||        :.||.| |:|..|        .:.|.|:|
Zfish  1474 NKPM-----------PT--------MDQSPK-FDLSVL--------TQAILKWE----------- 1499

  Fly   239 FQSLKKMKKYPTPIVSLSYQTCVDSHYFGFTLKTFRKDLVVDKFIIVQLRQFYYVYGAQMPL--- 300
            ::.|...|.:.:|:                       ||                  .|:||
Zfish  1500 YRMLDNYKAFGSPL-----------------------DL------------------CQLPLKEV 1523

  Fly   301 PVNGSGELVFFVDSHVFMI-----------LREQPIVIGFTIQGEKYVEQHHFMRTEALPKASFN 354
            |||.|..|.:|...:..::           |:|..:.:...:||.:|
Zfish  1524 PVNFSSYLEYFNTLYPLLLINAFEEMANEWLKEGRVKLYLKVQGIEY------------------ 1570

  Fly   355 INPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTL 419
                   |..|..:..:...:....|......||..:.|...||                 ||
Zfish  1571 -------SNRTASASFIAGLSQECDVKQIYPKEDDLVLLWLPDN-----------------TG-- 1609

  Fly   420 RTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPK 484
                            :..|.|...|      .:....|..|.|           .::|.....:
Zfish  1610 ----------------AYAQDEPNFH------DLHPHFGYVSRS-----------NVLNRTPGSR 1641

  Fly   485 SAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQL 549
            |.:...::...|                      |.|::.||                :.||
Zfish  1642 STLNLTIQTRGN----------------------VSSVNSQP----------------VLCE--- 1665

  Fly   550 PDNTTYTLIFRPLRAVMRYQYRAL--------------QQLSFTRHSDVQRILFPGEIPNTPLAS 600
                    :...|.::.| ::|||              ..:||..||    :..|.:: :.|
Zfish  1666 --------VVGSLISIFR-EFRALCLLRNGPMLRPLLAPHVSFFTHS----LDGPSDL-DAP--- 1713

  Fly   601 GVLQLNNKLISTNPEQMQAVR-QIALSPR-LKAP--YIVFGPPGTGKTSTIVEAIYQ-------- 653
                      ..|.:|.:|:. .||:..| .|.|  .::.|||||||:.||...:|:
Zfish  1714 ----------EFNRDQARAIACGIAMIHRKQKTPKFLLIHGPPGTGKSKTIGGLLYKLLSSATNS 1768

  Fly   654 ------LYINRPETHILVLAGSNTACDEVALRLL----------------------------RAI 684
                  |:.....|.:|:.|.||.|.|.:..:::                            |.|
Zfish  1769 SATVGNLHSKSRRTRVLLCAPSNAAIDSLMKKVILIFKEKCRNINAPQGNCGDINLVRLGNERTI 1833

  Fly   685 AKA---------PQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNM------YTVHFYPAVQAVHQ 734
            :|:         .:::.:...:...::..||.:.:|.::...|:.      .:..|...::...|
Zfish  1834 SKSLKPFSLDHQTKARAQRAQQTVESDVHRRKEQLDQMIENLSHQCAKTQKNSTEFKNLLEQKKQ 1898

  Fly   735 Y-----------------------------RIVICTLSLAGKL-STGGF--AANNVYTHVFVDEA 767
            :                             .::.||||.:|.: ....|  ..:..::.|.:|||
Zfish  1899 FLKEREGLSRQIKECRGRRQESQALVLQNAHVICCTLSTSGSIVLENAFRRLGHEPFSCVIIDEA 1963

  Fly   768 AASTEAEVLMGITCTLSPTL----NLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQV 828
            :.:.|.|       ||.|.|    ::||.||..||.|.:.||:|.|:|...:|..||    |..:
Zfish  1964 SQAKETE-------TLIPMLYRCPSVILVGDPNQLPPTVVSQKAKEFGFDQSLMARL----CKSL 2017

  Fly   829 EEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEA-PMEIVCRFHNWFYLPNATFPIMF 892
            ....|....: ..|...:|.||:|....:...|...|:.:. ..:..|.. :|.:.|...|.:|
Zfish  2018 HPSNSKLPPI-LLLSMQYRMHPDICEFPSKYIYNSALKNDCETAQKRCSL-SWPFKPYKVFDVM- 2079

  Fly   893 HSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQL- 956
                 ....||...|..|:||:.:|...:|.|.       |.....:|:|:||..|..||.:.:
Zfish  2080 -----DGRETKERDSFINHKEVSLVGLLLKLLC-------KEQAVRVGVITPYNAQKHRILDAIK 2132

  Fly   957 --NMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP--KLGFLNNERRLNVLLSRPISLLILIGN 1017
              .:....|::..:|:.|||:|...||||.||:.:.  .:||:.|.:|:||.::|....|.::|:
Zfish  2133 TSGINKQLQVEVDTVDGFQGREMDCIIVSCVRASSEMGSIGFVGNRQRMNVTITRAKFSLFILGH 2197

  Fly  1018 PRTLSQNSDFQHIIEMCRNRKTLVGEQYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLKRK 1082
            .|||.:.||:..:||....|:.::.....|.:                       |.:::.:|:|
Zfish  2198 LRTLREQSDWGALIEDAGRRECIINTMQKNFE-----------------------SDVKKIVKQK 2239

  Fly  1083 NHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPKVPRSVDHDLDEVRSIEAQLKDFQ 1147
               .||:.                                    ||:.|
Zfish  2240 ---PNPLS------------------------------------RSLSH---------------- 2249

  Fly  1148 LETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHS------SSVSRPAIRKPTVSAA 1206
                            .|:..   ||.:.|        |.:||      |||.||  ...|..||
Zfish  2250 ----------------PPIDR---PSAVIR--------PVMHSPVEAGPSSVPRP--HHDTTQAA 2285

  Fly  1207 TPVAK------SRSP-MPEIPS----SSKHPISMSSNPLSTNTERCVNGVLCGIEAVPPSENKTT 1260
            .|:.:      .:.| |.:.||    |.:.||...:...|...             :|.|.:.:.
Zfish  2286 QPMPRLIPLECPKDPRMNDRPSDPRFSERRPIREETQDRSRRD-------------IPASRHSSQ 2337

  Fly  1261 RSSAY--NHIPSG-NFRFENVRPTPEEVRRFNGANDQRR 1296
            ||::|  :|..|| :.|:.:         :..|::..||
Zfish  2338 RSNSYDGSHRSSGQSSRYSS---------KHRGSSPPRR 2367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	151/729 (21%)
		AAA_19	618..687	CDD:289986	26/114 (23%)
		AAA_12	812..1019	CDD:289832	55/212 (26%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	58/290 (20%)
		AAA_12	2005..2197	CDD:289832	54/210 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750