DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and helz2a

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_003198895.2	Gene:	helz2a / 562461	ZFINID:	ZDB-GENE-120920-1	Length:	2656	Species:	Danio rerio

Alignment Length:	1282	Identity:	263/1282 - (20%)
Similarity:	461/1282 - (35%)	Gaps:	360/1282 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 KDFEL--QSLGCYICQ--ENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVSLSYQ-TCVDS 263
            ||.:|  :||   ||:  :|..|....||..|:   ::..::::...:.......|||| ..:|.
Zfish   187 KDLKLCERSL---ICEYGDNCTKAHSQEELQEW---QTRVRAVRNKARDAASQGLLSYQDNLLDE 245

  Fly   264 HYFGFTLKTFRKDLVVDKFIIVQLRQFYYVY------------------------------GAQM 298
            :......|....|.:.|.||... |....||                              ||:.
Zfish   246 YRHSKDKKMIMTDTIPDVFITCD-RDLDAVYVRKRGIQCTWNFTIISKEPLEVIALLRREQGAKF 309

  Fly   299 PLPVNGSGELVFFVDS----------HVFMI--------LREQPIVIGFTIQGEKYVEQHHFMRT 345
            .|......|..:...:          |...:        |.||.:|..|..:  ..:.|...:|.
Zfish   310 SLSKKPDEERSYSTSAWFEKRTEQTGHEIPVSFRSDQPGLYEQWVVFDFNTR--PVLRQKLKVRV 372

  Fly   346 -----------EAL---PKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASF 396
                       |||   |:|:.|:.|:...|               :.::..::.|.||..|.
Zfish   373 GEDDCQAAPAPEALLENPEAACNLEPWNEES---------------MTIIPFVETEKAQRDLL-- 420

  Fly   397 DNQYQ----NYCERGREITQENLTGTLRTLLQVED--IERLQHYLSLK-----QSEMELHQFGRE 450
             |:||    |....|. |.:||...::...|..|:  :..|...|||:     ::|:...:||.:
Zfish   421 -NRYQLIMMNQQMNGL-INRENYKWSMHNFLYQEEKVVGELLSRLSLRGTVQLKNELSDDRFGMK 483

  Fly   451 LSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNV 515
            .:...:: ..::.:...|:|......|.::...:|.|| :::||.
Zfish   484 WAHPGEL-FAAVPLSQPLTPDAPQGFIVKRHAIRSLVR-VVKNNE-------------------- 526

  Fly   516 DGMVGSLDKQPRVYFARIL--GVSTQRVNITCERQ------LPDNTTYTLIFRPLRAVMRYQYRA 572
              ..|.      :|.|..|  ..|..:|::...::      |.:...|.         |..|::
Zfish   527 --YCGP------IYEAEFLKDAASETQVHLQLSKRCCAALNLQNGEEYE---------MEVQFQ- 573

  Fly   573 LQQLSFTRHSDVQRILF---PGEIPNTPLASGVL-QLNNKLISTN--------PEQMQAVRQIAL 625
                       |.|:.|   ...|.:.|....|| .|.|..:|.:        .|:.||.....|
Zfish   574 -----------VNRLWFCEMHKAIDDLPRMDKVLPDLKNAHLSISFQSDEGEFNEKQQAAMDFVL 627

  Fly   626 S--------PRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLR 682
            .        |    |.:::||.|||||.|:.: :.|..:.:|...||:...:|::.|........
Zfish   628 GVSDNRSSIP----PLLIYGPFGTGKTRTLAK-MAQALVQQPHNKILICTHTNSSADLYIKAHFH 687

  Fly   683 AIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEY------SNMYTVHFYPAVQAVHQYRIVICT 741
            ...:..|...||| ||.:  .:.::.:.|.:.|:|      :|.:.   :|....:...||||.|
Zfish   688 EYVRNGQLHARPL-RIKA--MEIKLASTDFITLQYCHLSREANCFE---FPDKAVLDSTRIVITT 746

  Fly   742 LSLAG-----KLSTGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPV 801
            .|||.     ||      ..|.::|:.:|||:...|.|.||.::...:.| .::|:|||.|:||.
Zfish   747 TSLARFFNDMKL------PENYFSHILIDEASQMLECEALMALSLAGNNT-RVVLAGDHMQMGPK 804

  Fly   802 LQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLI--RNFRSHPEIVSLYNNMYYEGH 864
            |.|.|.::.. ..||..||...  ||.|..   :.:.|:|:|  .|:||..:||...:..:|.|.
Zfish   805 LFSVRPDKCS-EHTLLNRLFYH--YQAENS---DVAKQSRIIFNENYRSTKDIVDFVSTHFYVGR 863

  Fly   865 LRTEAPMEIVCRFHNWFYLPN--ATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYF 927
                  .:::....|   :|:  ....:.||.|.|.......|:|..|.::|..|:..::::|
Zfish   864 ------SDVIKARGN---VPSHPQQHALQFHHVRGECCLDPMSMSWFNAEQIVRVVHILQEIM-- 917

  Fly   928 GLNGEKLLQTDIGIISPYK-------NQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFV 985
                 |....:.|...|..       .|...|:.:|.:....:....:.|..|||:..||::|.|
Zfish   918 -----KEWPQEWGAADPESVCVLSQGRQVLEIRYRLRLLGLPRFTVENAENVQGKQFRVIVISTV 977

  Fly   986 RS-----FTPK--LGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGE 1043
            .:     .|.:  |.|.|:.|.||.:::|..|.:.::|:...||     .|...||........|
Zfish   978 HTKDSLLETDRTCLEFFNDMRVLNTIMTRAQSQIFVVGDAAALS-----CHQFGMCWRLWRAYIE 1037

  Fly  1044 QYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNEC 1108
            :.:|::                :..|.....|:|.|         ::.:|:..|::|
Zfish  1038 ECINKE----------------SCHDLTLDSLKQDL---------LEISKLCRSEDE-------- 1069

  Fly  1109 QRKKSELETIFDELPKVPRSVDHD-LDEVRSIEAQLKD------FQLETKQDAAGTSILVTNAPV 1166
              :.|:.|:...|||.....:..: |||.:.|...|.:      ||.:....:|...:.......
Zfish  1070 --ENSDSESTTSELPDTEDLILQELLDESKEINVALTEEGLFPVFQNQEAFSSANNQVAEVYYEE 1132

  Fly  1167 TNAAAPSVIPRAGLMKQETPALHSSSVSRPAIR-----KPTVSAATPVAKSRSPMPEIPSSSKHP 1226
            ....:.:|..:..::|:.....::..:....:|     :..:..|.|..|   ...||.|::.||
Zfish  1133 PMFTSSTVHKQCEIVKEGYDRGYAKPLDESTLRIDIKGRANIGRAFPGDK---VTVEILSATSHP 1194

  Fly  1227 ---------------------ISMSSNPLSTNTERCVNGVLCGIEAVPPSENKTTRSSAYNHIPS 1270
                                 :....|.:.|...:|:..:.     .|..::|.      |||..
Zfish  1195 PMGRVINILESADTVKEFVCALERHDNQVMTPINKCITKIF-----TPFWKDKP------NHIAV 1248

  Fly  1271 GNFRFENVRPTPEEVRRFNGANDQRRARP------------FREPHG 1305
            .|       |...:|.:|...|::...:.            ||.|.|
Zfish  1249 RN-------PESLKVEKFIKINEEAHRKSLFIVKVLSWRNVFRYPLG 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	155/676 (23%)
		AAA_19	618..687	CDD:289986	19/76 (25%)
		AAA_12	812..1019	CDD:289832	53/224 (24%)
helz2a	XP_003198895.2	AAA_11	614..807	CDD:289831	59/210 (28%)
		P-loop_NTPase	639..>683	CDD:304359	14/44 (32%)
		DNA2	<741..1055	CDD:224037	92/363 (25%)
		UvrD_C_2	817..1017	CDD:304668	53/220 (24%)
		RNB	1338..1698	CDD:214935
		AAA_11	2168..2405	CDD:289831
		AAA_19	2176..2246	CDD:289986
		P-loop_NTPase	<2366..2438	CDD:304359
		AAA_12	2414..2614	CDD:289832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810