DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and mov10b.1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001037807.2	Gene:	mov10b.1 / 556024	ZFINID:	ZDB-GENE-030131-9089	Length:	1013	Species:	Danio rerio

Alignment Length:	973	Identity:	274/973 - (28%)
Similarity:	445/973 - (45%)	Gaps:	174/973 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 STTDV--PGGAPAEGNKPIIEEYKLDTDVKPTLLK----------FQKRLLLQSDKDFELQSLGC 213
            |||.|  |...|...|: :|...:|    ..|:::          |..:..::...:.:::....
Zfish   115 STTRVSDPSSVPEPENR-VIARRRL----AKTIMRQGNSEDMSVFFADKYGVRVSSELQIEDGKI 174

  Fly   214 YICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGFTLKTFRKD-- 276
            :.|.|..| :.:.:..||..|.|:...:......|      |.|.|..||       :..|||
Zfish   175 HWCVEGAE-VHELKLFVENTGQEAILFTCFSALHY------LQYFTLDDS-------QRVRKDNP 225

  Fly   277 ---------LVVDKFIIVQLRQFYYVYGAQMPLPVNGSGELVFFVDSHVFMILREQPIVIGFTIQ 332
                     .|:.:|...|:.    ||.|.:..      |.....|:..|.|:|
Zfish   226 HRLEPNETYEVILRFKSDQIG----VYPATLAF------EFKENQDTRPFHIVR----------- 269

  Fly   333 GEKYVEQHHFMRTEALPKASFNINPYRLSSKETFKSKGLPPANPPIQ--VLSALKHEDAQMCLAS 395
               ::|..|  |:|...         :|...|.|:.|.| ..|.|::  :....|.|.:......
Zfish   270 ---FIEAQH--RSELTA---------QLGPTEPFRPKRL-DTNQPMKWSIDEGFKPESSSQNFLK 319

  Fly   396 FDNQYQNY-CERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGT 459
            |.....|| |........|.|.|...:..|::     :|.|:| :|::..:.:.....:.:.:..
Zfish   320 FVVPLDNYNCPSYTSALIEVLKGNRSSGKQLQ-----EHQLTL-ESDLSFNNYMDRFDLLLYLEE 378

  Fly   460 TSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLEL--ALKDFDSILRWARNVDGMVGSL 522
            ..|.::.......||.::.::.      :|:|     ||||  ..::..|:||.    |.::  |
Zfish   379 DQMRMDIKRYNKKDVSMVRDRD------KKLL-----VLELPGVSENRPSVLRG----DHLL--L 426

  Fly   523 DKQPRV-------YFARILGVSTQRVNITCERQL----PDNTTYTLIFRPLRAVMRYQYRALQQL 576
            .|...:       |...:..|...:|.:...::|    .||..:::.|...|..:|.|:||:..:
Zfish   427 TKSEELQNSNVTKYKGYVHRVELDQVKLGFSKRLLERFIDNMKFSVEFTINRLPLRLQHRAVHMV 491

  Fly   577 SFTRHSDVQRILFP-GEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPG 640
              .:| .::.:||| ......|::...|:|.::.:..||||..||..|.......|||:||||||
Zfish   492 --VQH-HLKDVLFPVASRRLNPVSPSALRLFDQKLEKNPEQKTAVCNIVAGTSKPAPYLVFGPPG 553

  Fly   641 TGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLL-------RAIAK--APQSQPRPLT 696
            ||||.||||||.|:..|.....||..|.||:|.|::..:|:       |.|.:  |....|:.:.
Zfish   554 TGKTVTIVEAIKQVEKNTGGARILACAPSNSAADQLGEKLITSQHVDARNIYRIYASSRNPKEIP 618

  Fly   697 RIFSANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTH 761
            ::...|.:...:||              .:|..:.:..|:||:|||..||:|.:|||...: ::|
Zfish   619 KVLENNSNVEGENI--------------IFPCKEDLMPYKIVVCTLVTAGRLVSGGFPVGH-FSH 668

  Fly   762 VFVDEAAASTEAEVLMGITCTL-SPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLL-QRK 824
            :|||||..:.|.|:::.:...| :.|..|:|:||.|||||:|:|..|.::||||:|.|||: |.:
Zfish   669 IFVDEAGHAVEPEIVISVAGLLNAETGQLVLAGDPKQLGPILRSPFAIKYGLGLSLLERLMTQNE 733

  Fly   825 CYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCR-FHNWFYLPNATF 888
            .||..:.|..|..| |:|::|:||||.|:.:.|.::|:..|:..|. ||..| :..|.:||...|
Zfish   734 LYQKGDTGFDNRYV-TKLLQNYRSHPSILKVPNELFYDNELKACAD-EISSRQYCTWEHLPKRGF 796

  Fly   889 PIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYF----GLNGEKLLQTDIGIISPYKNQY 949
            |::||.|.|......:|.|..|..|||.:|||:|.|:..    |:  .|:...|||||:||:.|.
Zfish   797 PVIFHGVVGKDERESTSPSFFNTSEIDKIMDYLKKLLLTQAKKGI--AKISPKDIGIIAPYRKQV 859

  Fly   950 QRIQEQL-------NMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP--------KLGFLNNER 999
            ::|::.:       ::....::..||||.|||:|:.|||||.|||...        .:|||.||:
Zfish   860 EKIRQAIKIHRELKSLSGIEELKVGSVEEFQGQERKVIIVSTVRSSKEHIILDDKFNIGFLKNEK 924

  Fly  1000 RLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQ--YLNE-DFITNKKTGAN 1059
            |.||.::|..:|||::|||..|..:..:...:..|...:...|..  :|.| |.|..:....|
Zfish   925 RFNVAVTRAKALLIMVGNPIILRTDEIWGRFMNYCIQERGYTGYDITHLEETDVIAERLLSLN 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	210/657 (32%)
		AAA_19	618..687	CDD:289986	34/77 (44%)
		AAA_12	812..1019	CDD:289832	89/227 (39%)
mov10b.1	NP_001037807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..129		6/13 (46%)
		P-loop_NTPase	526..>734	CDD:304359	87/222 (39%)
		AAA_11	526..713	CDD:289831	76/201 (38%)
		DEAG box	672..675		2/2 (100%)
		AAA_12	720..943	CDD:289832	88/226 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4307
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.680