DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and mov10b.2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	1047	Identity:	290/1047 - (27%)
Similarity:	460/1047 - (43%)	Gaps:	233/1047 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LNALPNSSEIRQKLSSQGA----TNIGSLLHRTNFLINTPRGNPNYRIKNFSLMDFRKEKFNLLD 151
            |.||.|:::.|  ||..|.    ||:.:.||...|       .|..|.:|
Zfish    64 LYALRNANKAR--LSRTGRVYFNTNVRTGLHDQWF-------RPRRRQQN--------------- 104

  Fly   152 EQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKD-FELQSLGCYI 215
                 :..|:..:|....|:....|...|..:....|  |:|:..:.|..:|:. |.....|..:
Zfish   105 -----QANATPGNVSSVTPSSDQGPSCPESGVRARRK--LVKYILQRLNTTDRSHFIADKWGVRV 162

  Fly   216 CQE----------NFEKIEKYE--EHVEYHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGF 268
            ..|          :.::.|.||  ..||..|.|:.:.:      |.|.:..|.|          |
Zfish   163 SSELYIEDGKIRISVDEAEVYELKLFVENTGQEAVYFT------YYTALCWLQY----------F 211

  Fly   269 TLKTFRKDLVVDKFIIVQLRQFYYVYGAQMPLPVNGSGELVFFVDSHV--------FMILRE-QP 324
            ||:..|| :..:..:.::.|:.|.|              :|.|..|||        |...:. ||
Zfish   212 TLEDSRK-VTRNNPLRLEPREKYEV--------------IVRFKSSHVGVYSATLAFEFKKNTQP 261

  Fly   325 IVIGFTIQGEKYVEQHHFMRTEALPKASFNINPYRLSSKE---TFKSKGLPPANPPIQVLSALKH 386
            ....|.|  .:::|..:..:..||...:....|.||:..|   ....:|.||
Zfish   262 TTRSFHI--VRFIEAEYRSKLAALLGPTEPYKPLRLNISEPENCIIDEGFPP------------- 311

  Fly   387 EDAQMCLASFDNQYQNYCER----GREITQENLTGTLRTLLQVEDIE------RLQHYLSLKQSE 441
                      |...||:...    |:.|...:.| .|..||: ||..      :|:...||.||.
Zfish   312 ----------DGYLQNFLVNVLPLGKYIPPPDTT-ILAELLK-EDCSSRIFRGKLKDLQSLLQSP 364

  Fly   442 MELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELAL---- 502
            :....:.....:.:.:....|.| ||            |...|.:|....:.:..::.|.|
Zfish   365 LTFDNYAERFDLLLYLEECQMHV-DI------------KRYNKDSVTLHRDRDKRLMGLNLPGVS 416

  Fly   503 KDFDSILRWARNVDGMVGSLDKQPRVYFARIL-------GVSTQRVNITCERQL-----PDNTTY 555
            ::..|:||.    |.::  |.|...|.|:.:.       .|...:|.:...::.     .|...:
Zfish   417 ENRPSVLRG----DHLL--LTKSEEVTFSNVTKYKGYVHRVELDQVKLGLSKRFLKDVYIDKMKF 475

  Fly   556 TLIFRPLRAVMRYQYRALQQLSFTRHSDVQR----ILFP-GEIPNTPLASGVLQLNNKLISTNPE 615
            .:.|...|..:|.|:||:       |..||.    :||| ......|::...|:|.::.:..|.:
Zfish   476 RVEFTVNRIPVRLQHRAV-------HMAVQHNLKDVLFPMASRSLNPVSPPALRLFDRKLEYNFQ 533

  Fly   616 QMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRL 680
            |..||..|.......|||:||||||||||.||||||.|:..|.|:.:||..|.||:|.|::..:|
Zfish   534 QYSAVCNIVAGTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKL 598

  Fly   681 L-----------RAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAVHQ 734
            :           |..|.:...:..|  :|...||     |:|:.:::         :|..:.:..
Zfish   599 ITSEHVDAHKIYRLYASSRNQKDIP--KILKDNC-----NVDEEMID---------FPCKEDLMS 647

  Fly   735 YRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTL-NLILSGDHKQL 798
            |:|:||||..||:|.||||:.:: :||.|||||..:.|:|.::.:...|:... .|:|:||.|||
Zfish   648 YKILICTLVTAGRLVTGGFSEDH-FTHNFVDEAGHAVESETIISVAGLLNAEKGQLVLAGDPKQL 711

  Fly   799 GPVLQSQRANEWGLGLTLFERLL-QRKCYQ---VEEDGSYNASVQTRLIRNFRSHPEIVSLYNNM 859
            ||:|:|..|...||.::|.|||: |...|:   ||.|..|    .::||.|:||||.|:.:.|.:
Zfish   712 GPILRSPLAINHGLDVSLLERLMTQNDLYKRGDVEFDNRY----VSKLIMNYRSHPYILEVPNRL 772

  Fly   860 YYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDL 924
            :|:|.|:..|......::..|.:||:..||::||.|.|......:|.|..|..||::::||:|.|
Zfish   773 FYDGELKACADEISSNQYCMWEHLPSKGFPVIFHGVPGKDERESNSPSFFNIYEINILVDYLKKL 837

  Fly   925 MYF----GLNGEKLLQTDIGIISPYKNQYQRIQEQL----NMRNWSQID---CGSVELFQGKEKH 978
            :..    |::  ::...|||||:||:.|.::|:..:    :.:::..||   .||||.|||:|:.
Zfish   838 LLTQPKKGIS--RIFPKDIGIIAPYRKQVEKIKRAIDADKDFQDYMGIDNLKVGSVEEFQGQERK 900

  Fly   979 VIIVSFVRSF--------TPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCR 1035
            ||:||.|||.        |..:|||.||:|.||.::|..||||::|||..|..:..:...|:.|.
Zfish   901 VIMVSTVRSSVKYISLDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMILRTDESWGRFIDFCL 965

  Fly  1036 NRKTLVG 1042
            .|....|
Zfish   966 ERGGYTG 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	211/674 (31%)
		AAA_19	618..687	CDD:289986	35/79 (44%)
		AAA_12	812..1019	CDD:289832	85/229 (37%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130		9/62 (15%)
		MYCBPAP	<189..>262	CDD:291319	23/103 (22%)
		AAA_11	552..718	CDD:289831	69/182 (38%)
		P-loop_NTPase	552..>714	CDD:304359	67/178 (38%)
		DNA2	<642..983	CDD:224037	127/338 (38%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	84/228 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4307
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.680