DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6701 and ZGRF1

DIOPT Version :9

Sequence 1:NP_001188923.1 Gene:CG6701 / 36550 FlyBaseID:FBgn0033889 Length:1333 Species:Drosophila melanogaster
Sequence 2:NP_060862.3 Gene:ZGRF1 / 55345 HGNCID:25654 Length:2104 Species:Homo sapiens


Alignment Length:1325 Identity:293/1325 - (22%)
Similarity:461/1325 - (34%) Gaps:428/1325 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 PPGT-YANGMPRKPTVPWERELMGSFLLEMARLQVISAQTEWYV------------DKAKMRKLF 87
            |..| |.|.|...|.:|       |..:::..|||.|.:.....            |:..|.:..
Human   966 PDSTEYENFMTETPELP-------STCMQIDFLQVTSPEENISTLSPVSTFSLNSRDEDFMVEFS 1023

  Fly    88 EVHLNA--LPN-----SSEIRQKLSSQGATNIG--SLLHRTNF-LINTPR--GNP-----NYRIK 135
            |..|.|  ||:     :.|..:|..|....|:.  |||.||.. ||..||  |.|     :|.|.
Human  1024 ETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDSHSYMIN 1088

  Fly   136 ---------------------NFSLMD-------FRKE---------KFNLLDEQHRLRGIASTT 163
                                 :||:..       |.:|         ..|.:..|.:.....:|:
Human  1089 SNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDVSLNNISTQSKWLKYQNTS 1153

  Fly   164 DVPGGAPAEGNKPI------------------------IEEYKLDTDVKPTLLKFQKRLLLQSDK 204
            ......|...:|.|                        :.|..||:    ..|:..|.:|.|..:
Human  1154 QCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDS----VHLQMIKGMLYQQRQ 1214

  Fly   205 DFELQ---------SLGCYICQENFEKIEKYEE--HV---------------EYHGDESDFQSLK 243
            ||..|         ||       |.::..|.||  :|               |..|.|..|.|.:
Human  1215 DFSSQDSVSRKKVLSL-------NLKQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQ 1272

  Fly   244 KMKKYPTPIVSLSYQTCVDS--HYFGFTLKTFRKDLVVDKFIIVQLRQFYYVYGAQMPLPVNGSG 306
            |:|....|...:.......|  ||    .:||...|:....|                       
Human  1273 KIKSAYLPQRQIHIPAVFQSPAHY----KQTFTSCLIEHLNI----------------------- 1310

  Fly   307 ELVFFVDSHVFMILREQPIVIGFTIQGEKYVEQ-------HHFMRTEALPKASFNINPYRL---- 360
             |:|.:..::...|.:..|....:::|||....       ||....:.:.......|..||    
Human  1311 -LLFGLAQNLQKALSKVDISFYTSLKGEKLKNAENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTC 1374

  Fly   361 ----SSKETFKSKGLPPANP---------PIQVLSALK-------------HEDAQMCL-ASFDN 398
                :.:..| .|.|....|         |..|||.:|             :|:.|:.: ..||.
Human  1375 DGPKADRCKF-FKWLEDVTPGYSTQEGARPGMVLSDIKSIGLYLRSQKIPLYEECQLLVRKGFDF 1438

  Fly   399 QYQNYCERGREITQENLTGTLRTLLQVE----DIERLQHYLSLKQSEMELHQFGRELSVKMQMGT 459
            |.:.|             |.|:....|.    :..:.:.||.|.:.|..      ....|..:..
Human  1439 QRKQY-------------GKLKKFTTVNPEFYNEPKTKLYLKLSRKERS------SAYSKNDLWV 1484

  Fly   460 TSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKD-FDSILRWARNVDGMVGSLD 523
            .|.:::..|   |..:..:....|.|.        |.:..|.||. |.|  .|..|   ||    
Human  1485 VSKTLDFEL---DTFIACSAFFGPSSI--------NEIEILPLKGYFPS--NWPTN---MV---- 1529

  Fly   524 KQPRVYFARILGVSTQRVNITCERQLPDN--------TTYTLIFRPLRAV--MRYQYRALQQLSF 578
                |:...:...||:   :|..:.:.|.        |.|.|.......|  .|...|.....:|
Human  1530 ----VHALLVCNASTE---LTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAF 1587

  Fly   579 TRHSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPY---------- 633
            |..|....:|..|  ....|||.::|: :||   |.:|..|:.|||   ::.|.:          
Human  1588 TNVSTKFELLSLG--ATLKLASELIQV-HKL---NKDQATALIQIA---QMMASHESIEEVKELQ 1643

  Fly   634 -------IVFGPPGTGKT---STIVEAIYQLYI--------NRPETHILVLAGSNTACDEVALRL 680
                   |:.|..|.||:   :.::....||:.        |.....:|:.:.:|.|.|.|.|.|
Human  1644 THTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGL 1708

  Fly   681 L-------------RAIAK--APQSQPRPLTRIFSANCDRRIDNIDDLLLE-YSNMYTVHFYPAV 729
            |             |.|||  .|.|     ....|.|...::..:..|:.| .:....|:...::
Human  1709 LSLGFENFIRVGSVRKIAKPILPYS-----LHAGSENESEQLKELHALMKEDLTPTERVYVRKSI 1768

  Fly   730 Q---------AVHQYRIVICTLSLAGKLSTGGFAANN--VYTHVFVDEAAASTEAEVLMGIT--- 780
            :         .:.|.|:|..|.:..      .|...|  .:..|.:||.:..||...|:.|.   
Human  1769 EQHKLGTNRTLLKQVRVVGVTCAAC------PFPCMNDLKFPVVVLDECSQITEPASLLPIARFE 1827

  Fly   781 CTLSPTLNLILSGDHKQLGPVLQ-SQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIR 844
            |.     .|||.||.|||.|.:| |..|:|.||..|||:||    |..    |.....::|:   
Human  1828 CE-----KLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRL----CLM----GHKPILLRTQ--- 1876

  Fly   845 NFRSHPEIVSLYNNMYYEGHLR---TEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSV 906
             :|.||.|.::.|:::|:|.|.   ||.....:..     :||.    :.|::|.|.....:.: 
Human  1877 -YRCHPAISAIANDLFYKGALMNGVTEIERSPLLE-----WLPT----LCFYNVKGLEQIERDN- 1930

  Fly   907 SLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNW-----SQIDC 966
            |..|..|....:..::.|:..|:.|..     ||:|:.||:|..::...|:..::     ..:..
Human  1931 SFHNVAEATFTLKLIQSLIASGIAGSM-----IGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQV 1990

  Fly   967 GSVELFQGKEKHVIIVSFVRSFTPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHII 1031
            .:|:.|||.||.:||:|.||  |.::||:::|:|:||.|:|....|:::||...|.:|..:..:|
Human  1991 STVDAFQGAEKEIIILSCVR--TRQVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVI 2053

  Fly  1032 EMCRNRKTLVGEQYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFY 1096
            :.|..|:.  |.|:.|:                           .:|  :.||.      .|.::
Human  2054 QHCEGRED--GLQHANQ---------------------------YEP--QLNHL------LKDYF 2081

  Fly  1097 SKNELLNLGNECQRKKSELETIFDE 1121
            .|..     .|.|:||||.|...|:
Human  2082 EKQV-----EEKQKKKSEKEKSKDK 2101

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6701NP_001188923.1 TIGR00376 424..1037 CDD:273041 169/694 (24%)
AAA_19 618..687 CDD:289986 25/111 (23%)
AAA_12 812..1019 CDD:289832 60/214 (28%)
ZGRF1NP_060862.3 AAA_11 1614..1844 CDD:289831 59/251 (24%)
DNA2 <1739..2057 CDD:224037 95/357 (27%)
AAA_12 1855..2039 CDD:289832 58/212 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2085..2104 8/22 (36%)
DUF2439 4..73 CDD:287368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..359
zf-GRF 1347..1391 CDD:284302 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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