Protein Alignment CG6701 and MOV10L1

DIOPT Version :9

• Sequence 1: NP_001188923.1
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_011528998.1
• Gene: MOV10L1 / 54456
• HGNCID: 7201
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 1155
• Identity: 262/1155 - (22%)
• Similarity: 440/1155 - (38%)
• Gaps: 361/1155 - (31%)

  Fly   159 IASTTDVPGGAPAEGNKP-----IIEEYKL--------DTDVKPTLLKFQKRLLLQSDKDFELQS 210
            |:.||.....:..||.:|     :..||::        .|.|||...|...::.:.|
Human   134 ISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLRYKRVDKVCISS-------- 190

  Fly   211 LGCYICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTP--------IVSLSYQTCV------ 261
                :|..|    ...||.:.:..|     |||....| ||        :|..|.|:|.
Human   191 ----LCGRN----GVLEESIFFTLD-----SLKLPDGY-TPRRGDVVNAVVVESSQSCYVWRALC 241

  Fly   262 --------------DSHYFGFTLKTFRKDLVVDKFIIVQLRQFYYVYGAQ---MPLPVNGSGELV 309
                          .:|::|..|...:.|:.|     .|:..|..:...:   |.:.:...|::
Human   242 MTLVKRRDAAPVHEATHFYGTILLKNKGDIEV-----TQVTHFGTLKEGRSKTMVIWIENKGDI- 300

  Fly   310 FFVDSHVFMILREQPIVIGFTIQGEKYVEQHHFM---RTEALPKASF------------NINPY- 358
                         ...::...:.|....:|..|.   :.:..|..||            |||..
Human   301 -------------PQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPEKENSSDENINSLN 352

  Fly   359 --------RLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENL 415
                    ::|......::|:.|.:                |....:|..::.....:::|:...
Human   353 SHTKNKTSQMSESSLVNNRGISPGD----------------CTCKGENGEKDNILSRKQMTEPEP 401

  Fly   416 TGTL----RTLLQV----EDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSM---------- 462
            .|.:    :|.:.|    ::..|.:..|.|..|:..:   ||.|.|.:..|..|:
Human   402 GGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLI---GRYLEVNVISGEESLIAAREPFSWK 463

  Fly   463 ---SVEDILSPGDDVLIINEKGNPK-------------SAVRKMLENNNNVL------------- 498
               |.:.:.|....|::..:|.|.:             ..:||.:|...::|
Human   464 KLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMS 528

  Fly   499 -----------------ELALKDFDS---ILRWARNVDGMV----GSLDKQPRVYFARILGVSTQ 539
                             |:.||:::.   |||  ||.|.:|    |..:.:|.:|....|.:.||
Human   529 NYKEKFSTLLWLEEIYAEMELKEYNMSGIILR--RNGDLLVLEVPGLAEGRPSLYAGDKLILKTQ 591

  Fly   540 RVN-----------------ITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQ-- 585
            ..|                 :|.:........|.  |.|:.....|.....::..|.....:.
Human   592 EYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYN--FEPMDVEFTYNRTTSRRCHFALEHVIHLG 654

  Fly   586 -RILFPGE-IPNTPLASG--------------VLQLNNKLIS----------------------- 611
             ::|||.| |..:|..:|              ..:.|.|.::
Human   655 VKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPF 719

  Fly   612 -------------------------TNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAI 651
                                     .|..|..||::|........|||:|||||||||.||:||:
Human   720 TAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAV 784

  Fly   652 YQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLE 716
            .|::...|::.|||.|.||:|.|.|.|||    .::...||..:.|: :|.|     ..::::::
Human   785 LQVHFALPDSRILVCAPSNSAADLVCLRL----HESKVLQPATMVRV-NATC-----RFEEIVID 839

  Fly   717 YSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVL--MGI 779
            ....| ......:....::||:|.|.|.:|.....|....: :||||||||..::|.|.|  :|:
Human   840 AVKPY-CRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGH-FTHVFVDEAGQASEPECLIPLGL 902

  Fly   780 TCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEED-----GSYNASVQ 839
            ...:|.  .::|:||..|||||::|:.|..:||.::..|||:.|..||.:|:     |::|..:.
Human   903 MSDISG--QIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLV 965

  Fly   840 TRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKS 904
            |:|::|:|||..::.|.:.::|...|...|...:|.....|..||...||::||.|.|:......
Human   966 TKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGK 1030

  Fly   905 SVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQY-------------------- 949
            |.|..|..|...|:.|. .|:...::.: :..:|||:|:||:.|:
Human  1031 SPSWFNPAEAVQVLRYC-CLLAHSISSQ-VSASDIGVITPYRKQWLWSSGGDTGASHAEHQVSFM 1093

  Fly   950 ------------------QRIQEQLN-----MRNWSQID--CGSVELFQGKEKHVIIVSFVRSFT 989
                              |..:|::.     :||...:|  .||||.|||:|..|||:|.|||..
Human  1094 KHVSLWCSHHQAELGKNPQNTEEKVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNE 1158

  Fly   990 PK-------LGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIE 1032
            .:       ||||:|.:|.||.::||.:|||::|||..|.::..|..::|
Human  1159 DRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLE 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	207/818 (25%)
		AAA_19	618..687	CDD:289986	33/68 (49%)
		AAA_12	812..1019	CDD:289832	79/263 (30%)
MOV10L1	XP_011528998.1	DNA2	426..1217	CDD:224037	205/806 (25%)
		P-loop_NTPase	744..>922	CDD:304359	67/191 (35%)
		AAA_12	933..1194	CDD:289832	78/262 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650