DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and MOV10

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens

Alignment Length:	1010	Identity:	290/1010 - (28%)
Similarity:	444/1010 - (43%)	Gaps:	213/1010 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EQHRLRGIASTT-DVPGGAPAEG----------------NKPIIEEYKLD--TDVKPTLLKFQKR 197
            ::.|||.|.:.. .:..|.||.|                .|..:..::||  .||:   ...::|
Human    31 DRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVR---FPEKRR 92

  Fly   198 LLLQSDKDFELQSLGCYICQENFEKIE-KYEEHVEYHG--DESDFQSLKKMKKYPTPIVSLSYQT 259
            :.|.||.....:||...|..:..|.:. |:...||..|  :..|.|.|.::......:::|..:.
Human    93 MKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRN 157

  Fly   260 CVDSHYFGFTLKTFRKDLVVDKFIIVQLRQF-YYVYGAQMPLPVNGSGEL--------VFFVDSH 315
                   |.|.......|    |.:.:..|| :|....::|.|: |.||.        ..||...
Human   158 -------GGTQSVTLTHL----FPLCRTPQFAFYNEDQELPCPL-GPGECYELHVHCKTSFVGYF 210

  Fly   316 VFMILRE--QPIVIGFTIQGEKYVEQ------HHFMRTEALPKASFNI-----NPY---RLSSKE 364
            ...:|.|  .|...|....|..|:.:      |..:..:..|...|..     ||.   |:...|
Human   211 PATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGE 275

  Fly   365 -TFKSKG------------LPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQ---- 412
             ..::||            .||  |.::.|..:..:...:..|.            :||.:
Human   276 RPDRAKGYDLELSMALGTYYPP--PRLRQLLPMLLQGTSIFTAP------------KEIAEIKAQ 326

  Fly   413 -------ENLTGTLRTLLQVEDIER---LQHYLSLKQSEM---ELHQFGRELSVKMQMGTTSMSV 464
                   .|....||.||.:|:::.   ::|| .|:...|   .:.|..|.|::::. |.|. |.
Human   327 LETALKWRNYEVKLRLLLHLEELQMEHDIRHY-DLESVPMTWDPVDQNPRLLTLEVP-GVTE-SR 388

  Fly   465 EDILSPGDDVLII----NEKGNP---KSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSL 522
            ..:|. ||.:..:    ..:.:|   |..|.| :|.:...|..::    |:|  :|.|||:
Human   389 PSVLR-GDHLFALLSSETHQEDPITYKGFVHK-VELDRVKLSFSM----SLL--SRFVDGL---- 441

  Fly   523 DKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRI 587
                           |.:||.|..||            |||.    |:|||:   .|....:..:
Human   442 ---------------TFKVNFTFNRQ------------PLRV----QHRALE---LTGRWLLWPM 472

  Fly   588 LFPGEIPNTP-LASGV-LQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEA 650
            |||....:.| |.|.| |:|.::.:.:||||:||:|.|.......||||:|||||||||.|:|||
Human   473 LFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEA 537

  Fly   651 IYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRI-------- 707
            |.|:..:.|:.|||..|.||:..|.:..||...:       |..:.|:.:.:.|.|:
Human   538 IKQVVKHLPKAHILACAPSNSGADLLCQRLRVHL-------PSSIYRLLAPSRDIRMVPEDIKPC 595

  Fly   708 DNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTE 772
            .|.|....||       .:||.:.:.:||::|.||..||:|.:..|..:: :||:|:|||....|
Human   596 CNWDAKKGEY-------VFPAKKKLQEYRVLITTLITAGRLVSAQFPIDH-FTHIFIDEAGHCME 652

  Fly   773 AEVLMGITC------TLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLL-QRKCYQVEE 830
            .|.|:.|..      |..|...|:|:||.:||||||:|....:.|||.:|.|||| ....|:...
Human   653 PESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGP 717

  Fly   831 DGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSV 895
            || |:....|:|:||:||||.|:.:.|.:||||.|:..|.:....||..|..||...|||:||.|
Human   718 DG-YDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGV 781

  Fly   896 FGTTMNTKSSVSLCNNKEIDVVMDYVKDLMY-FGLNGE-KLLQTDIGIISPYKNQYQRI------ 952
            .|......:|.|..|.:|...|..|:|.|:. ....|: :|....:|:||||:.|.::|
Human   782 MGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITK 846

  Fly   953 --QEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP--------KLGFLNNERRLNVLLSR 1007
              :|...:.:...:..||||.|||:|:.||::|.|||...        .||||.|.:|.||.::|
Human   847 LDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTR 911

  Fly  1008 PISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVG 1042
            ..:|||::|||..|..:.|::..:|.|:......|
Human   912 AKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTG 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	219/660 (33%)
		AAA_19	618..687	CDD:289986	33/68 (49%)
		AAA_12	812..1019	CDD:289832	85/225 (38%)
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	95/250 (38%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	73/204 (36%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.630