DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and CG6967

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	276/822 - (33%)
Similarity:	422/822 - (51%)	Gaps:	139/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 PPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLS 436
            ||:|   :::.|..::|    |::.::.:.::.:..| :...|:...::|||.::|:..::.|..
  Fly     8 PPSN---EMIEANTNQD----LSANNSVFGDFMKTKR-LEFYNVCSVMQTLLTIDDLSNMELYAQ 64

  Fly   437 LKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGN------PKSAVRKMLENNN 495
            |.||::.:.:..: |:.|:...:|.::.||.::|..|.:::..|.:      ||..|..:|.:.:
  Fly    65 LIQSDVPVQRVSK-LTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPH 128

  Fly   496 NVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQ----LPDNTTYT 556
            ..||..    |.:||       .|.|:||           ||:..|::...|:    |.....|.
  Fly   129 EDLEPG----DPMLR-------HVASVDK-----------VSSTTVHVRFSRKHKAVLSGQRFYA 171

  Fly   557 LIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFP-------------------GEIPN------- 595
            :| |..|..:||.||||..|.  ....|:|.|||                   |.:||
  Fly   172 II-RSRRLTIRYMYRALNLLQ--ESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQ 233

  Fly   596 TPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPE 660
            .|.....|.|.|..|.:|.||::||::|...|..:.|||:|||||||||:||||||.||.:.:|:
  Fly   234 EPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQ 298

  Fly   661 THILVLAGSNTACDEVALRLLRAIAK--------APQSQPRP---LTRIFSANC-DRRIDNIDDL 713
            :.|||.||||:|||.:||:|...|..        |.|..|.|   |.|::|.:. ::...::..|
  Fly   299 SRILVTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSL 363

  Fly   714 LLEYSNMYTVHFYPAVQA--VHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVL 776
            ||:.||. :...|..::|  :.:|.|::.||....:|.|......|.:||:|:|||.||||.|.|
  Fly   364 LLKNSNC-SKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEAL 427

  Fly   777 MGIT-CTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQT 840
            :||. ...:...::||||||||||.|::|.||...||..:|.|||||..||:.:|:|:|:.:.|.
  Fly   428 IGIMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQM 492

  Fly   841 RLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSS 905
            ||.||:||||:||.|:|.:||.|.|:.:||...|....||..|.|..|||:|.:..|.|...::|
  Fly   493 RLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNS 557

  Fly   906 VSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVE 970
            .|..||.|.:|:..|||.|    :|...:.|.|:||::||..|.:.:.:.|..:.:..::.||||
  Fly   558 TSSYNNLEAEVICWYVKRL----INDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVE 618

  Fly   971 LFQGKEKHVIIVSFVRSFTPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCR 1035
            .:||:||.:||.|.|:||| .:||:.|.||:||||||..:||||:|||.||..:|||:.:|..|:
  Fly   619 TYQGREKTIIIASLVKSFT-NMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECK 682

  Fly  1036 NRKTLVGEQYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNE 1100
            ...|     ||                                ||:::..:.|          :.
  Fly   683 KHGT-----YL--------------------------------LKKRDSGQRP----------HI 700

  Fly  1101 LLNLGNECQRKKSELETIFDEL-PKVPRSVDHDLDEVRSIEA 1141
            |:......:...||.|...|:| |...|...|....:..|:|
  Fly   701 LIKADESNEESSSEPEDEDDKLIPSYARMQQHTDAAIHKIKA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	248/663 (37%)
		AAA_19	618..687	CDD:289986	39/76 (51%)
		AAA_12	812..1019	CDD:289832	93/206 (45%)
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	88/205 (43%)
		AAA_19	256..323	CDD:289986	38/66 (58%)
		UvrD_C_2	464..665	CDD:304668	92/205 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468788
Domainoid	1	1.000	139	1.000	Domainoid score	I1552
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	1	1.000	-	-		H119989
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		otm50367
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.700