DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Setx

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_006233948.1	Gene:	Setx / 362096	RGDID:	1565575	Length:	2702	Species:	Rattus norvegicus

Alignment Length:	1477	Identity:	274/1477 - (18%)
Similarity:	485/1477 - (32%)	Gaps:	565/1477 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RKPTVPWERELMGSFLLEMARLQVISAQTEWYVDKAKMRKLFEVHLNALPNSSEIRQKLSSQGAT 110
            |||.:|          |.:||                         ::.|.:::|....|:....
  Rat  1562 RKPGLP----------LSVAR-------------------------SSRPTTTKIFSSSSASRTA 1591

  Fly   111 NIGSLLHRTNF--------------LINTPRGN-----PNYRIKNF-SLMDFR------KEKFNL 149
            |:...|..|..              |..||..:     |...:|:. ::..|:      |:.:..
  Rat  1592 NLSKSLESTTLQSALKNKSSGAQSNLKMTPSSSLGSQKPVAEVKSLCNIFHFQTPSSSSKQSYKF 1656

  Fly   150 LDEQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCY 214
            ...::|....||:.|:.  .|::.        ..||.:| .:||::.::.|..||.....||
  Rat  1657 TFSENRPASAASSVDIL--LPSQS--------IFDTFIK-EVLKWKYQMFLNFDKCGAPTSL--- 1707

  Fly   215 ICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHYFGFTLKTFRKDLVV 279
             |                       ||:.:    |.|:   .:|.|.:  ||    ..|...:::
  Rat  1708 -C-----------------------QSISR----PVPV---RFQDCAE--YF----NVFLPLIIL 1735

  Fly   280 DKFIIV--------QLRQFYYVYGAQMPLPVNGSGE-LVFFVDSHVFMILREQPIVIGFTIQGEK 335
            :.|..|        ....||.::..:.|.......| |::..:|.:...|..:...:.|.:..:|
  Rat  1736 NAFETVAQEWLNSPNKENFYQLHLRKFPADYKKYWEFLIYLEESELAKQLHPKENDLVFLVPEKK 1800

  Fly   336 YVEQH------HFMRTEALPKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLA 394
            |:::|      |:.        ...::.:|.:|                 |:.:.|.| ..:|:.
  Rat  1801 YMDRHSVQDRSHYY--------CGYVHKFRRTS-----------------VMRSGKTE-CSLCIQ 1839

  Fly   395 SFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGT 459
            :.||...:..|..:.|...:|..|.|                 |...|.|      ||.:.|:..
  Rat  1840 TQDNMPASVKELTKCIVISSLVTTQR-----------------KLKAMSL------LSGRNQLAR 1881

  Fly   460 TSMSVEDILSPGDDVLIINEKGNPKS-AVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLD 523
            .      :|:|           ||.. ..:.:|...:..:...||||:.               |
  Rat  1882 A------VLNP-----------NPMDFCTKDLLTTTSERIIAYLKDFNE---------------D 1914

  Fly   524 KQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRIL 588
            ::..:                       .|.|.::                     :||
  Rat  1915 QKKAI-----------------------ETAYAMV---------------------KHS------ 1929

  Fly   589 FPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQ 653
                                         .:|.:|.|         :.|||||||:.|||..:|:
  Rat  1930 -----------------------------PSVAKICL---------IHGPPGTGKSKTIVGLLYR 1956

  Fly   654 LYINR--------------PETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPL--------- 695
            |....              .:..:||.|.||.|.||:..:::....:..:.:..||
  Rat  1957 LLTESQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLV 2021

  Fly   696 ---------TRIFSANCD-------------------RRIDNIDDLLLEYSNMYTV--------- 723
                     |.:...:.|                   ||.:.:|..|.|.|....:
  Rat  2022 RLGPEKSINTEVLKFSLDSQVSHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQR 2086

  Fly   724 -----HF-------------YPAVQA---------VHQYRIVICTLSLAGKL-------STGGFA 754
                 |.             ...||.         :.:..::.||||.:|.|       ..||..
  Rat  2087 QELDEHIVIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVP 2151

  Fly   755 ANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLN----LILSGDHKQLGPVLQSQRANEWGLGLT 815
                ::.|.||||..|.|.|       ||||.::    |:|.||.|||.|.:.|.:|.|:|..
  Rat  2152 ----FSCVIVDEAGQSCEVE-------TLSPLIHRCNKLVLVGDPKQLPPTVISMKAQEYGYD-- 2203

  Fly   816 LFERLLQRKCYQVEEDGSYNASVQTRLIR---NFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRF 877
              :.::.|.|..:||:...|...:..:::   .:|.||:|....:|..|..:|:|....|.:...
  Rat  2204 --QSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTETIRCS 2266

  Fly   878 HNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEK---LLQTDI 939
            ..|.:.|...|.:      |.....:.:.|..|.:||.:||:.:|      |..||   :...:|
  Rat  2267 SEWPFQPYLVFDV------GDGSEQRDNDSYINVQEIKLVMEIIK------LIKEKRKDISFRNI 2319

  Fly   940 GIISPYKNQYQRIQEQLN----------------------------------MRNWSQIDCG--- 967
            |||:.||.|...||:.|.                                  |....::|..
  Rat  2320 GIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSECMHASDELDSSTVT 2384

  Fly   968 --------------------SVELFQGKEKHVIIVSFVRSFTPK--LGFLNNERRLNVLLSRPIS 1010
                                :|:.|||::|..|||:.||:...:  :|||.:.:||||.::|...
  Rat  2385 QSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKY 2449

  Fly  1011 LLILIGNPRTLSQNSDFQHIIEMCRNRKTLV---GEQYLNEDF------------ITNKKTGANN 1060
            .|.::|:.|||.:|..:..:|:..:.|..::   ...|.::..            :|:....|..
  Rat  2450 SLFILGHLRTLMENQHWYELIQDAQKRGAIIKTCDPNYRHDAMKILKLKPVLQRSLTHPPATAPE 2514

  Fly  1061 VNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDEL--P 1123
            ..:  ..|..|::.|...|...:.|.:      ::::.::.:.      .|:.|...:.|.|  |
  Rat  2515 APR--PQGGLPSNRLDSGLATTSFAPS------LYHTPSDTVT------SKEPERPLLQDRLRDP 2565

  Fly  1124 KVPRSVDHDLDEVRSIEAQ---LKDFQLETKQDAAGTSIL-VTNAPVTNAAAPSVIPRAGLMKQE 1184
            ::.|.:|        .||:   |:|.|.|:.|......:| .:..||.......|:|
  Rat  2566 RLLRRLD--------AEAKGTFLRDPQPESPQLPGVVHLLGESGCPVLFQDLGFVVP-------- 2614

  Fly  1185 TPALHSSSVSRPAIRKPTVSAATPVAKSRSPMPEIPSSSKHPISMSSNPLSTNTERCVNGVLCGI 1249
                            |:.:...|:...|||:...|..: ||.:.:|     .::|..:....|:
  Rat  2615 ----------------PSTAIVAPLGSHRSPIQAEPRPA-HPAAAAS-----TSKRKYSDPDAGL 2657

  Fly  1250 EAVPPSENKTTRSSAYNHIPSGNFRFENVRPTPEEVRRFNGANDQRR 1296
                 |..:..|:.|......|:.....:|.|..:.||.:.::.:||
  Rat  2658 -----SHRREPRAFAGEQGRHGSVTHHALRSTDLDRRRLDDSSAKRR 2699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	153/776 (20%)
		AAA_19	618..687	CDD:289986	23/82 (28%)
		AAA_12	812..1019	CDD:289832	60/271 (22%)
Setx	XP_006233948.1	SEN1_N	37..>356	CDD:289496
		AAA_11	1910..2195	CDD:289831	71/398 (18%)
		AAA_19	1934..>1997	CDD:289986	22/71 (31%)
		AAA_12	2202..2456	CDD:289832	59/269 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850